Abstract:
The disclosure pertains to mixtures of LaFeSiH magnetic nanoparticles having different Curie temperatures useful for improved inductive hyperthermia efficiency, injectable formulations containing the nanoparticles, and methods of raising the temperature of selected cells using the nanoparticles.
Abstract:
The present disclosure relates to devices, systems and methods for evaluating the success of a treatment applied to tissue in a patient, such as a radio frequency ablative treatment used to neuromodulate nerves associated with the renal artery. A system monitors parameters or values generated during the course of a treatment. Feedback provided to an operator is based on the monitored values and relates to an assessment of the likelihood that a completed treatment was technically successful. In other embodiments, parameters or values generated during the course of an incomplete treatment (such as due to high temperature or high impedance conditions) may be evaluated to provide additional instructions or feedback to an operator.
Abstract:
Disclosed is a device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient, the device comprising an electrically controllable redistribution component attachable to the patient and being configured to interact with the patient to provide redistribution of the cardiac output to increase supply to the brain and heart, the redistribution component following a predefined reaction pattern based on an electrical signal, and computer means configured to: receive a patient data which identifies physiological and/or anatomical characteristics of the patient; and provide the electrical signal for the redistribution component based on the patient data or a standard response. The device may provide mechanisms to protect the aorta and the remaining anatomy of the patient from inadvertent damage caused by the disclosed device in any usage scenario of either correct intended usage or unintended usage. Also disclosed is a method for providing resuscitation or suspended state.
Abstract:
A heat exchange assembly can be removably engaged between two cold plates of a heat exchange system for exchanging heat with working fluid from an intravascular heat exchange catheter or an external heat exchange pad. The heat exchange assembly may have a serpentine, winding, tortuous, or sinuous configuration, or it may have one or more curves, turns and/or bends and/or can have a flattened transverse cross-section to facilitate heat exchange with the cold plates.
Abstract:
An intravascular temperature management catheter includes a shaft through which working fluid can circulate to and from a proximal location on the shaft. The catheter extends from a connector hub. At least one heat exchange member is supported by a distal part of the shaft or other part of the catheter to receive circulating working fluid from the proximal location. A temperature sensor is supported on the catheter for generating a temperature signal representative of blood temperature to a control system. The temperature sensor includes first and second conductive leads having respective first and second distal segments on or in the catheter shaft. The first and second distal segments are arranged to be in thermal contact with blood flowing past the catheter when the catheter is disposed in a blood vessel of a patient. Also, the temperature sensor includes a joining body connected to proximal segments of the first and second leads. The joining body may be supported in the hub or in another location proximal to the first and second conductive leads.
Abstract:
Disclosed is a device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient, the device comprising an electrically controllable redistribution component attachable to the patient and being configured to interact with the patient to provide redistribution of the cardiac output to increase supply to the brain and heart, the redistribution component following a predefined reaction pattern based on an electrical signal, and computer means configured to: receive a patient data which identifies physiological and/or anatomical characteristics of the patient; and provide the electrical signal for the redistribution component based on the patient data or a standard response. The device may provide mechanisms to protect the aorta and the remaining anatomy of the patient from inadvertent damage caused by the disclosed device in any usage scenario of either correct intended usage or unintended usage. Also disclosed is a method for providing resuscitation or suspended state.
Abstract:
A catheter for target body temperature management, a system for target temperature management, and a method for target body temperature management, including a catheter, system or method for target body temperature management in cavities, such as the nasopharynx route, of a body.
Abstract:
A peristaltic pump has an arcuate raceway (32, 130) with a partially concave inner surface (36, 136) extending through an arc of at least one hundred eighty degrees (180). The arc defines a midpoint (38/138), and a rotor (34/134) faces the inner surface of the raceway (32, 130) and is both rotatable relative to the raceway (32, 130) and translationally movable relative to the raceway (32, 130) between a pump position, wherein the rotor (34/134) is spaced from the midpoint (38/138) a first distance, and a tube load position, wherein the rotor (34/134) is spaced from the midpoint (38/138) a second distance greater than the first distance. A rotor motor (58) is coupled to the rotor (34/134) to rotate the rotor and rollers (46, 48) are arranged on the rotor to contact tubing disposed between the rotor (34/134) and the raceway (32, 130) when the rotor (34, 134) is in the pump position. A manual positioning mechanism (70) or a loading motor (140) can move the rotor (34 or 134) toward and away from the raceway (32, 130).
Abstract:
The present invention discloses a heat-balance-type circulating pipe system, comprising a control system, a circulating hyperthermal perfusion heating device and a perfusion device; the circulating hyperthermal perfusion heating device and the perfusion device are both connected with the control system; the circulating hyperthermal perfusion heating device comprises molecular rings, a plurality of magnetic field generators for heating a heating tank, an induction ring coiled on a sleeve and a heater consisting of inductors placed in the heating tank; the perfusion device comprises an inlet connecting member, an outlet connecting member, an infusion member and the heating tank; the inlet connecting member and the outlet connecting member are communicated and then connected to the infusion member through a three-way joint; the inlet connecting member and the outlet connecting member are respectively connected with the heating tank; the heating tank comprises an outer heating tank and an inner heating tank which are sleeved together; the inner heating tank is internally and horizontally provided with an inner stirrer; and the inner heating tank is provided with an upper heating tank cover; and the upper heating tank cover is provided with a temperature control and detection sensor. The heat exchange efficiency is high; the hyperthermic perfusion therapeutic effect is good; and quick and uniform heat effect is good.