公开(公告)号：EP2646437B1

公开(公告)日：2014-09-03

申请号：EP11787778.7

申请日：2011-11-17

申请人： Eli Lilly and Company

发明人： LAMAS-PETEIRA, Carlos ,  RICHARDS, Simon, James ,  SAPMAZ, Selma ,  WALTER, Magnus, Wilhelm

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P25/16

CPC分类号： C07D487/04 ,  C07D471/04

公开(公告)号：EP2668152A2

公开(公告)日：2013-12-04

申请号：EP12701809.1

申请日：2012-01-13

申请人： Eli Lilly and Company

发明人： DEFAUW, Jean Marie ,  HOLMSTROM, Scott Dale ,  CHEN, Shuhui ,  ZHANG, Yang ,  WU, Wentao ,  PENG, Xian ,  MA, Yujuan ,  LU, Lun

IPC分类号： C07C217/54

CPC分类号： C07C215/64 ,  C07C217/74 ,  C07C219/28 ,  C07C219/30 ,  C07C2602/20 ,  C07C2602/42 ,  C07C2602/44 ,  C07C2602/50

摘要： Provided are analgesic compounds, and salts thereof, of formula: (I) wherein A is: (A) Additionally, pharmaceutical formulations and methods of use employing the above compounds are provided.

摘要翻译： 提供了式（I）的镇痛化合物及其盐，其中A是：（A）另外，提供了使用上述化合物的药物制剂和使用方法。

公开(公告)号：EP2659007A2

公开(公告)日：2013-11-06

申请号：EP11813620.9

申请日：2011-12-21

申请人： Eli Lilly and Company

发明人： WEISE, Dale, Wade ,  HARRIS, James, Robert

IPC分类号： C12Q1/70

CPC分类号： C12Q1/70 ,  C12Q1/701

摘要： Disclosed are methods and compositions for identifying viral-specific polynucleotide sequences in a biological sample, and particularly in samples of veterinary origin. Also disclosed are oligonucleotide primer pairs, as well as labeled oligonucleotide detection probes useful in detecting the presence of one or more particular species, strains, types, or subtypes of one or more mammalian pathogens of viral origin, as well as systems, diagnostic kits and articles of manufacture comprising virus-specific primers and labeled detection probes, including those useful in identifying viral components of a multivalent vaccine, and quantitating the potency of particular attenuated, live viruses that comprise a livestock vaccine. In certain embodiments, real-time, quantitative PCR methods have been utilized to identify and distinguish between the three known genetic subtypes of bovine viral diarrhea virsuses (BVDV-la, BVDV-lb, and BVDV-2) in a multivalent bovid shipping fever vaccine.

公开(公告)号：EP2646445A1

公开(公告)日：2013-10-09

申请号：EP11791146.1

申请日：2011-11-17

申请人： Eli Lilly and Company

发明人： COATES, David, Andrew ,  GILMOUR, Raymond ,  MARTIN, Jose, Alfredo ,  MARTIN DE LA NAVA, Eva, Maria

IPC分类号： C07D498/04 ,  A61K31/424 ,  A61P35/00

CPC分类号： C07D413/12 ,  A61K31/424 ,  A61K31/437 ,  C07D498/04

摘要： The present invention provides oxazolo[5,4-b]pyridin-5-yl compounds useful in the treatment of cancer.

公开(公告)号：EP2618830A1

公开(公告)日：2013-07-31

申请号：EP11764063.1

申请日：2011-09-22

申请人： Eli Lilly and Company

发明人： DAVAGNINO, Juan ,  KHA, Catherine, Ngan ,  KLOTZ, Alan Voskamp

IPC分类号： A61K38/19 ,  C07K14/535 ,  A61P29/00

CPC分类号： A61K38/193 ,  C07K14/535

摘要： This invention provides stable aqueous formulations comprising a bG-CSF polypeptide or a variant thereof, a buffer substance, and an excipient, wherein said formulation is substantially free of polyoxyethylene (20) sorbitan monolaurate. The invention also provides methods of using, a lyophilized or powdered form of, and processes for, preparing the formulation.

公开(公告)号：EP2358698B1

公开(公告)日：2012-09-05

申请号：EP09752059.7

申请日：2009-11-05

申请人： Eli Lilly and Company

发明人： BASTIAN, Jolie, Anne ,  CLAY, Julia, Marie ,  COHEN, Jeffrey, Daniel ,  HIPSKIND, Philip, Arthur ,  LOBB, Karen, Lynn ,  SALL, Daniel, Jon ,  WILSON (NEE TAKAKUWA), Takako ,  THOMPSON, Michelle, Lee

IPC分类号： C07D401/04 ,  A61K31/501 ,  C07D401/14 ,  C07D417/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D417/14

公开(公告)号：EP2365001A3

公开(公告)日：2012-03-28

申请号：EP10177137.6

申请日：2004-05-03

申请人： Imclone LLC

发明人： Ludwig, Dale L

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/2896 ,  A61K39/39541 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/77 ,  A61K2300/00

摘要： This invention relates to human antibodies that bind to human insulin-like growth factor-1 receptor (IGF-IR), to derivatives of these antibodies (Fabs, single chain antibodies, bi-specific antibodies, or fusion proteins), and to uses of the antibodies and derivatives in therapeutic, and diagnostic methods. The invention relates to nucleic acids encoding the anti-IGF-IR, methods of generating the antibodies and expression. The invention further relates to combination therapies using ant-IGF-IR antibodies with antineoplastic drugs.

公开(公告)号：EP2427449A1

公开(公告)日：2012-03-14

申请号：EP10717402.1

申请日：2010-05-04

申请人： Eli Lilly and Company

发明人： CHEN, Daohong ,  LI, Hong-Yu ,  ZHAO, Genshi

IPC分类号： C07D401/14 ,  A61K31/4439

CPC分类号： C07D401/14 ,  A61K31/4439

摘要： The present invention provides vinyl indazoiyl compounds useful in the treatment of cancer.

摘要翻译： 本发明提供可用于治疗癌症的乙烯基吲唑烷基化合物。

公开(公告)号：EP2201002B1

公开(公告)日：2012-03-07

申请号：EP08836911.1

申请日：2008-09-30

申请人： ELI LILLY AND COMPANY

发明人： BADESCU, Valentina, O. ,  FILLA, Sandra, Ann ,  GALLAGHER, Peter, Thaddeus ,  WHATTON, Maria, Ann

IPC分类号： C07D401/14 ,  C07D403/12 ,  A61K31/497 ,  A61P25/00

CPC分类号： C07D401/14 ,  C07D403/12 ,  C07D403/14

摘要： The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: where A is C(H)= or -N= and R1-7 are as defined herein.

公开(公告)号：EP2417124A2

公开(公告)日：2012-02-15

申请号：EP10713753.1

申请日：2010-04-06

申请人： Eli Lilly and Company

发明人： DREYFUS, Nicolas, Jacques, Francois ,  FILLA, Sandra, Ann ,  JOHANSSON, Anette, Margareta ,  MASQUELIN, Thierry, J. ,  SHAH, Jikesh, Arvind ,  TROMICZAK, Eric, George ,  WALTER, Magnus, Wilhelm

IPC分类号： C07D401/12 ,  A61P25/00 ,  A61K31/4439

CPC分类号： C07D401/12 ,  A61K31/4439

摘要： A serotonin and norepinephrine reuptake inhibitor of the formula: (I) its uses, and methods for its preparation are described.