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1.发明授权OXAZOLO[5,4-B]PYRIDIN-5-YL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER 有权唑并[5,4-b]吡啶-5- CONNECTIONS其适合于治疗癌症的
公开(公告)号：EP2646445B1
公开(公告)日：2016-03-16
申请号：EP11791146.1
申请日：2011-11-17
发明人： COATES, David, Andrew , GILMOUR, Raymond , MARTIN, Jose, Alfredo , MARTIN DE LA NAVA, Eva, Maria
IPC分类号： A61K31/437 , C07D413/12 , C07D498/04 , A61K31/424
CPC分类号： C07D413/12 , A61K31/424 , A61K31/437 , C07D498/04
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2.发明授权SUBSTITUTED [(5H-PYRROLO[2,1-c] [1,4]BENZODIAZEPIN-11-YL)PIPERAZIN-1-YL]-2,2-DIMETHYLPROPANOIC ACID COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS 有权取代的[（5H-吡咯并[2,1-C] [1,4]苯并二氮杂-11-基）哌嗪-1-基] -2,2-二DIMETHYLPROPANSÄUREVERBINDUNGENALS双作用H1-逆激动剂/拮抗剂5-HT2A
公开(公告)号：EP2683719B1
公开(公告)日：2015-03-18
申请号：EP12701824.0
申请日：2012-01-25
发明人： CAMP, Anne, Marie , GALLAGHER, Peter, Thaddeus , SANDERSON, Adam, Jan , LEDGARD, Andrew, James , COATES, David, Andrew
IPC分类号： C07D487/04 , A61K31/5517 , A61P25/20
CPC分类号： C07D487/04
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3.发明公开SUBSTITUTED [(5H-PYRROLO[2,1-c] [1,4]BENZODIAZEPIN-11-YL)PIPERAZIN-1-YL]-2,2-DIMETHYLPROPANOIC ACID COMPOUNDS AS DUAL ACTIVITY H1 INVERSE AGONISTS/5-HT2A ANTAGONISTS 有权取代的[（5H-吡咯并[2,1-C] [1,4]苯并二氮杂-11-基）哌嗪-1-基] -2,2-二DIMETHYLPROPANSÄUREVERBINDUNGENALS双作用H1-逆激动剂/拮抗剂5-HT2A
公开(公告)号：EP2683719A1
公开(公告)日：2014-01-15
申请号：EP12701824.0
申请日：2012-01-25
发明人： CAMP, Anne, Marie , GALLAGHER, Peter, Thaddeus , SANDERSON, Adam, Jan , LEDGARD, Andrew, James , COATES, David, Andrew
IPC分类号： C07D487/04 , A61K31/5517 , A61P25/20
CPC分类号： C07D487/04
摘要： A dual H1/5-HT
2A receptor antagonist of the formula:, its uses, and methods for its preparation are described.-
公开(公告)号：EP4126842A1
公开(公告)日：2023-02-08
申请号：EP21732765.9
申请日：2021-05-24
IPC分类号： C07D401/12 , A61K31/444 , A61P23/00
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公开(公告)号：EP3996713A1
公开(公告)日：2022-05-18
申请号：EP20751396.1
申请日：2020-07-06
发明人： ABURUB, Aktham , COATES, David, Andrew , FRANK, Scott, Alan , KERR, Mark, Steven , ROTHHAAR, Roger, Ryan , VAID, Radhe, Krishan
IPC分类号： A61K31/444 , A61P25/06 , C07D401/06
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6.发明公开OXAZOLO [5, 4 -B]PYRIDIN- 5 -YL COMPOUNDS AND THEIR USE FOR THE TREATMENT OF CANCER 有权唑并[5,4-b]吡啶-5- CONNECTIONS其适合于治疗癌症的
公开(公告)号：EP2646445A1
公开(公告)日：2013-10-09
申请号：EP11791146.1
申请日：2011-11-17
发明人： COATES, David, Andrew , GILMOUR, Raymond , MARTIN, Jose, Alfredo , MARTIN DE LA NAVA, Eva, Maria
IPC分类号： C07D498/04 , A61K31/424 , A61P35/00
CPC分类号： C07D413/12 , A61K31/424 , A61K31/437 , C07D498/04
摘要： The present invention provides oxazolo[5,4-b]pyridin-5-yl compounds useful in the treatment of cancer.
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公开(公告)号：EP2406252B1
公开(公告)日：2015-05-20
申请号：EP10707770.3
申请日：2010-03-04
IPC分类号： C07D405/06 , C07D405/14 , C07D498/04 , A61K31/4184 , A61K31/5383 , A61P13/12 , A61P3/10 , A61P5/40
CPC分类号： C07D405/06 , C07D405/14 , C07D498/04
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公开(公告)号：EP2379528B1
公开(公告)日：2013-09-18
申请号：EP09775477.4
申请日：2009-12-15
发明人： COATES, David, Andrew , DE DIOS MAGANA, Alfonso , DE PRADO GONZALES, Ana , DEL PRADO CATALINA, Miriam Filadelfa , GARCIA PAREDES, Maria, Cristina , GELBERT, Lawrence, Mark , KNOBELOCH, John, Monte , MARTIN DE LA NAVA, Eva, Maria , MARTIN ORTEGA FINGER, Maria, Dolores , MARTINEZ PEREZ, Jose, Antonio , MATEO HERRANZ, Ana, Isabel , PEREZ MARTINEZ, Carlos , SANCHEZ MARTINEZ, Concepcion
IPC分类号： C07D401/14 , A61K31/517 , A61P35/00
CPC分类号： C07D401/14
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公开(公告)号：EP2406252A1
公开(公告)日：2012-01-18
申请号：EP10707770.3
申请日：2010-03-04
IPC分类号： C07D405/06 , C07D405/14 , C07D498/04 , A61K31/4184 , A61K31/5383 , A61P13/12 , A61P3/10 , A61P5/40
CPC分类号： C07D405/06 , C07D405/14 , C07D498/04
摘要： The present invention provides a compound of the formula: Compound (I) or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising Compound (I) in combination with a suitable carrier, diluent, or excipient; and methods for treating physiological disorders, particularly congestive heart failure, hypertension, diabetic nephropathy, or chronic kidney disease, comprising administering Compound (I), or a pharmaceutically acceptable salt thereof.
摘要翻译： 本发明提供下式化合物：化合物（I）或其药学上可接受的盐; 包含化合物（I）与合适的载体，稀释剂或赋形剂组合的药物组合物; 和治疗生理疾病，特别是充血性心力衰竭，高血压，糖尿病肾病或慢性肾病的方法，包括给予化合物（I）或其药学上可接受的盐。
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公开(公告)号：EP2379528A1
公开(公告)日：2011-10-26
申请号：EP09775477.4
申请日：2009-12-15
发明人： COATES, David, Andrew , DE DIOS MAGANA, Alfonso , DE PRADO GONZALES, Ana , DEL PRADO CATALINA, Miriam Filadelfa , GARCIA PAREDES, Maria, Cristina , GELBERT, Lawrence, Mark , KNOBELOCH, John, Monte , MARTIN DE LA NAVA, Eva, Maria , MARTIN ORTEGA FINGER, Maria, Dolores , MARTINEZ PEREZ, Jose, Antonio , MATEO HERRANZ, Ana, Isabel , PEREZ MARTINEZ, Carlos , SANCHEZ MARTINEZ, Concepcion
IPC分类号： C07D401/14 , A61K31/517 , A61P35/00
CPC分类号： C07D401/14
摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof which is useful in the treatment of cell proliferative diseases.
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