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公开(公告)号：EP3099295A1
公开(公告)日：2016-12-07
申请号：EP15705412.3
申请日：2015-01-27
申请人： Abbvie Inc.
发明人： AWNI, Walid M. , BADRI, Prajakta , COHEN, Daniel E. , DUTTA, Sandeep , KHATRI, Amit , MENON, Rajeev M. , POLEPALLY, Akshanth , TRINH, Roger , WANG, Tianli , ZHA, Jiuhong , PODSADECKI, Thomas J.
IPC分类号： A61K31/402 , A61K38/06 , A61K31/513 , A61P31/14
CPC分类号： A61K38/06 , A61K31/4025 , A61K31/427 , A61K31/496 , A61K31/497 , A61K31/513 , A61K31/55 , A61K38/05 , A61K45/06 , C07K5/0804 , A61K2300/00
摘要： This application features dose adjustment for drugs co-administered with Compound 1, Compound 2 and/or Compound 3.
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62.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开APOPTOSEINDUKTOREN ZUR BEHANDLUNG冯KREBS SOWIE VON IMMUN- UND AUTOIMMUNERKRANKUNGEN
公开(公告)号：EP3095784A1
公开(公告)日：2016-11-23
申请号：EP16174793.6
申请日：2010-01-15
申请人： AbbVie Inc.
发明人： KUNZER, Aaron, R. , ELMORE, Steven, W. , HEXAMER, Laura , PARK, Cheol-Min , SOUERS, Andrew, J. , SULLIVAN, Gerard, M. , WANG, Gary, T. , WANG, Xilu , WENDT, Michael, D.
IPC分类号： C07D333/42 , C07D285/135 , C07D409/12 , A61K31/381 , A61P35/00
CPC分类号： C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
摘要： Disclosed are compounds of Formula (1), in which A 1 , Z 1 , Z 1A , Z 2 , Z 2A , L 1 and Z 3 are as defined in the claims, which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and their use in treating diseases during which anti-apoptotic Bcl-2 protein is expressed.
摘要翻译： 公开了式（1）的化合物，其中A 1，Z 1，Z 1A，Z 2，Z 2A，L 1和Z 3如权利要求中所定义，其抑制抗凋亡Bcl-2蛋白的活性 含有这些化合物的组合物及其在治疗抗凋亡Bcl-2蛋白表达的疾病中的用途。
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公开(公告)号：EP3013827A4
公开(公告)日：2016-11-23
申请号：EP14818239
申请日：2014-06-27
申请人： ABBVIE INC
发明人： WANG LE , DAI YUJIA , HOLMS JAMES , LIU DACHUN , MCCLELLAN WILLIAM , MCDANIEL KEITH , HASVOLD LISA , FIDANZE STEVEN D , SHEPPARD GEORGE , MARJANOVIC JASMINA
IPC分类号： C07D471/04 , A61K31/437 , A61K31/506 , A61P3/00 , A61P3/04 , A61P3/10 , A61P13/12 , A61P15/16 , A61P31/12 , A61P31/18 , A61P35/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06
摘要： The present invention provides for compounds of formula (I). wherein Rx, Ry, Rx1, L1, G1, A1, A2, A3, and A4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprised of one or more compounds of formula (I).
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64.发明公开APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 有权细胞凋亡诱导剂治疗癌症和免疫及自身免疫疾病
公开(公告)号：EP3091017A1
公开(公告)日：2016-11-09
申请号：EP16161558.8
申请日：2011-05-25
申请人： AbbVie Inc.
IPC分类号： C07D471/04 , A61K31/44 , A61K31/18 , A61P35/00
CPC分类号： C07D471/04 , A61K31/18 , A61K31/44 , A61K31/496 , A61P35/00 , C07F9/65616 , Y02A50/385 , Y02A50/401 , Y02A50/411 , Y02A50/463
摘要： Disclosed are compounds of formula (Ia) which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
摘要翻译： 公开了抑制抗凋亡Bcl-2蛋白质活性的式（Ia）化合物，含有该化合物的组合物和治疗表达抗凋亡Bcl-2蛋白质的疾病的方法。
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65.发明公开COMPOSITIONS AND METHODS FOR TREATING OSTEOARTHRITIS 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON OSTEOARTHRITIS
公开(公告)号：EP3077418A2
公开(公告)日：2016-10-12
申请号：EP14824971.7
申请日：2014-12-02
申请人： AbbVie Inc.
发明人： WANG, Susanne, X.
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/245 , C07K2317/24 , C07K2317/31 , C07K2317/56 , C07K2317/76 , C07K2317/94
摘要： The present invention relates to the treatment of osteoarthritis in a human subject using anti- IL-lα and anti-IL-Ιβ DVD-Ig proteins. In various embodiments, the osteoarthritis includes knee osteoarthritis or hand osteoarthritis.
摘要翻译： 本发明涉及使用抗IL-1α和抗IL-1和bgr治疗人类受试者的骨关节炎。 DVD-Ig蛋白。 在各种实施方案中，骨关节炎包括膝关节骨性关节炎或手部骨关节炎。
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公开(公告)号：EP3066121A1
公开(公告)日：2016-09-14
申请号：EP14805732.6
申请日：2014-11-07
申请人： AbbVie Inc. , Althouse, Heidi , Ananthakrishnan, Shilpa , Coppola, Germano , Ennis, Scott , Hickman, Robert, Keith , Wang, Chen , Yakamavich, Joe
发明人： ALTHOUSE, Heidi , ANANTHAKRISHNAN, Shilpa , COPPOLA, Germano , ENNIS, Scott , HICKMAN, Robert, Keith , WANG, Chen , YAKAMAVICH, Joe
CPC分类号： C07K1/165 , A61K39/395 , C07K1/22 , C07K1/34 , C07K1/36 , C07K16/00 , C07K16/065
摘要： Chromatographic methods for isolating and purifying DVD-lgs™ from a sample, wherein the purified DVD-lgs™ have reduced host cell proteins, aggregates, and viruses compared to the sample.
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公开(公告)号：EP2892910B1
公开(公告)日：2016-09-07
申请号：EP13763430.9
申请日：2013-09-10
申请人： AbbVie Inc.
发明人： WAGNER, Rolf , CHEN, Hui-Ju , SHANLEY, Jason , BOGDAN, Andrew , MARJANOVIC, Jasmina , WANG, Xiu , DONNELLY-ROBERTS, Diana
CPC分类号： C07C261/00 , C07J63/008
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公开(公告)号：EP2817308B1
公开(公告)日：2016-09-07
申请号：EP13707095.9
申请日：2013-02-22
申请人： AbbVie Inc.
IPC分类号： C07D471/04 , C07D519/00 , A61K31/52 , A61P35/00
CPC分类号： C07D471/14 , A61K31/519 , C07D471/04 , C07D519/00
摘要： The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein R1, R2, R3, R4, and B are defined in the description. The present invention relates also to compositions containing said compounds which are useful for inhibiting kinases such as wee-1 and methods of treating diseases such as cancer.
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69.发明公开
公开(公告)号：EP3060234A1
公开(公告)日：2016-08-31
申请号：EP14802533.1
申请日：2014-10-24
申请人： AbbVie Inc.
IPC分类号： A61K38/13 , A61K39/395 , A61K45/06 , A61K31/167 , A61K31/192 , A61K31/198 , A61K31/4164 , A61K31/42 , A61K31/4353 , A61K31/4706 , A61K31/496 , A61K31/498 , A61K31/519 , A61K31/52 , A61K31/5415 , A61K31/573
CPC分类号： A61K31/4985 , A61K31/167 , A61K31/192 , A61K31/198 , A61K31/4164 , A61K31/42 , A61K31/4353 , A61K31/4706 , A61K31/496 , A61K31/498 , A61K31/519 , A61K31/52 , A61K31/5415 , A61K31/573 , A61K31/575 , A61K31/606 , A61K31/616 , A61K31/655 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The invention relates to the use of a JAKl kinase- selective inhibitor that has minimal inhibitory activity towards Jak2 kinase for treating a disease, such as an inflammatory disease (e.g., moderate to severe Rheumatoid Arthritis) and/or bone loss, either alone or in combination with a DMARD (disease modifying anti-rheumatic drug), such as methotrexate. The invention also provides pharmaceutical composition, dosage formulation, administration route, and dosage schedule thereof.
摘要翻译： 本发明涉及对Jak2激酶具有最小抑制活性的JAK1激酶选择性抑制剂的用途，用于治疗诸如炎性疾病（例如中度至重度类风湿关节炎）和/或骨丢失的疾病，单独使用或 与DMARD（疾病改善抗风湿药），如甲氨蝶呤组合。 本发明还提供药物组合物，剂量制剂，给药途径和剂量方案。
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70.发明公开AMINOCHROMANE, AMINOTHIOCHROMANE AND AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY 审中-公开氨基苯并二氢吡喃，AMINOTHIOCHROMAN-和氨基 - 1,2,3,4-四氢喹啉衍生物，药物组合物和正确使用IN THERAPY
公开(公告)号：EP3057960A1
公开(公告)日：2016-08-24
申请号：EP14790543.4
申请日：2014-10-16
发明人： AMBERG, Wilhelm , POHLKI, Frauke , LANGE, Udo , WANG, Ying , ZHAO, Hongyu , LI, Huan-Qiu , BREWER, Jason , VASUDEVAN, Anil , LAO, Yanbin , HUTCHINS, Charles W.
IPC分类号： C07D405/14 , C07D311/58 , C07D405/04 , A61K31/352 , A61P25/02
CPC分类号： A61K31/501 , A61K31/397 , A61K31/4155 , A61K31/4178 , A61K31/4192 , A61K31/4433 , C07D311/58 , C07D405/04 , C07D405/14
摘要： The invention relates to pharmaceutical compositions comprising such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, and the use of such aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives for therapeutic purposes. The aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives are GlyT1 inhibitors.
摘要翻译： 本发明涉及药物组合物，其包括寻求氨基苯并二氢吡喃噻喃及氨基-1,2,3,4-四氢喹啉衍生物，以及使用搜索的氨基苯并二氢吡喃噻喃及氨基-1,2,3,4-四氢喹啉衍生物用于治疗目的。 的氨基苯并二氢吡喃噻喃及氨基-1,2,3,4-四氢喹啉衍生物是GlyT1抑制剂。
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