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公开(公告)号：EP3658909A1
公开(公告)日：2020-06-03
申请号：EP18817634.1
申请日：2018-06-13
发明人： LIPKENS, Bart , MUSIAK, Ronald , MEALEY, Dane , ARTIS, John , SHAJII, Ali
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公开(公告)号：EP3360955A1
公开(公告)日：2018-08-15
申请号：EP18156760.3
申请日：2018-02-14
发明人： Lipkens, Bart , Masi, Louis , Kowalski III, Stanley , Presz Jr., Walter M. , Dionne, Jason , Dutra, Brian , Mercado, Ari , Kennedy III, Thomas J. , Martin, Arthur , Rozembersky, John
IPC分类号： C12M1/00
摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor.
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公开(公告)号：EP3341102A1
公开(公告)日：2018-07-04
申请号：EP16770116.8
申请日：2016-08-26
发明人： LIPKENS, Bart , PRESZ JR, Walter M. , KING, Jeffrey , BARNES, Jason , MEALEY, Dane , MCCARTHY, Brian , ROSS-JOHNSRUD, Benjamin , CHITALE, Kedar
CPC分类号： B01D21/283 , A61M1/3678 , B06B1/0622 , G10K11/28 , G10K11/34 , G10K15/00
摘要： Devices (100) for separating a host fluid from a second fluid or particulate are disclosed. The devices include an acoustic chamber (107), a fluid outlet at a top end of the acoustic chamber (114), a concentrate outlet at a bottom end of the acoustic chamber (116), and an inlet (112) on a first side end (122) of the acoustic chamber (107). An ultrasonic transducer (106) on a side wall of the acoustic chamber and reflector at the opposite side wall create a multi-dimensional acoustic standing wave in the acoustic chamber (107) that traps and separates particulates (e.g. cells) from a host fluid. The host fluid is collected via the fluid outlet (114), and the particulates are collected via the concentrate outlet (116). The device is a large-scale device that is able to process liters/hour, and has a large interior volume.
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公开(公告)号：EP3164488A4
公开(公告)日：2018-04-11
申请号：EP15814616
申请日：2015-07-02
申请人： FLODESIGN SONICS INC
发明人： LIPKENS BART , MCCARTHY BRIAN , BARNES JASON , MEALEY DANE , ROSS JOHNSRUD BEN , PRESZ JR WALTER M , CHITALE KEDAR
CPC分类号： B01D21/283 , B01D21/0045
摘要： An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.
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公开(公告)号：EP3288660A1
公开(公告)日：2018-03-07
申请号：EP16732365.8
申请日：2016-04-29
发明人： LIPKENS, Bart , PRESZ, Walter M. Jr. , CHITALE, Kedar , KENNEDY, Thomas J. III , ROSS-JOHNSRUD, Ben
CPC分类号： C12N13/00 , A61M1/3678 , B01D21/283 , B01L3/502761 , B01L2300/0864 , B01L2300/0867 , B01L2400/0436 , B01L2400/0439 , C12M47/04 , G01N15/1484 , G01N2015/0053 , G01N2015/1006 , G01N2015/149
摘要： Devices for separating materials from a host fluid are disclosed. The devices include a flow chamber, an ultrasonic transducer, and a reflector. The ultrasonic transducer and reflector create an angled acoustic standing wave oriented at an angle relative to the direction of mean flow through the flow chamber. The angled acoustic standing wave results in an acoustic radiation force having an axial force component that deflects the materials, so that the materials and the host fluid can thus be separated. The angled acoustic standing wave can be oriented at an angle of about 20° to about 70° relative to the direction of mean flow through the flow chamber to deflect, collect, differentiate, or fractionate the materials from the fluid flowing through the device at flow rates of about 400 mL/min up to about 700 mL/min.
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公开(公告)号：EP3019606A4
公开(公告)日：2017-04-05
申请号：EP14823682
申请日：2014-07-11
申请人： FLODESIGN SONICS INC
CPC分类号： C12N13/00 , B06B1/0238 , B06B1/0648 , B06B2201/76 , C07K1/145 , C12M47/02 , C12P21/02
摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.
摘要翻译： 在生物反应器的生长体积内建立一系列多维声驻波。 声波驻波被用于将细胞培养物保持在适当位置，因为营养液流流过细胞培养物。 通过营养液流收集由细胞培养产生的生物分子，并在细胞培养物的下游分离。
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67.发明公开
公开(公告)号：EP3126028A1
公开(公告)日：2017-02-08
申请号：EP15733002.8
申请日：2015-04-03
CPC分类号： B06B1/0644 , B01D21/283 , G10K11/20
摘要： An apparatus includes a flow chamber having at least one inlet and at least one outlet. At least one ultrasonic transducer is located on a wall of the flow chamber, which operates to create a multi-dimensional acoustic standing wave in the flow chamber. A reflector is located on the wall on the opposite side of the flow chamber from the at least one ultrasonic transducer. The reflector is formed from a thin structure that provides a pressure release boundary, such as a plastic film/air interface.
摘要翻译： 一种装置包括具有至少一个入口和至少一个出口的流动室。 至少一个超声换能器位于流动室的壁上，其操作以在流动室中产生多维声驻波。 反射器位于流动室的与至少一个超声波换能器相反的一侧的壁上。 反射器由提供压力释放边界的薄结构形成，例如塑料膜/空气界面。
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68.发明公开ACOUSTOPHORETIC SEPARATION TECHNOLOGY USING MULTI-DIMENSIONAL STANDING WAVES 审中-公开对于多维AKUSTOPHORETISCHE驻波分离技术
公开(公告)号：EP2903715A4
公开(公告)日：2016-10-05
申请号：EP13844181
申请日：2013-09-13
申请人： FLODESIGN SONICS INC
CPC分类号： B06B1/06 , B06B2201/70 , C12M47/02
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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69.发明公开ACOUSTOPHORESIS DEVICE WITH MODULAR COMPONENTS 审中-公开AKUSTOPHORESEVORRICHTUNG MIT MODULAREN KOMPONENTEN
公开(公告)号：EP3065795A1
公开(公告)日：2016-09-14
申请号：EP14812011.6
申请日：2014-11-05
发明人： LIPKENS, Bart , BARNES, Jason , MEALEY, Dane , PRESZ, Walter M. Jr , KOWALSKI, Stanley, III , MASI, Louis , KENNEDY, Thomas J., III , MCCARTHY, Brian , ROSS-JOHNSRUD, Ben
CPC分类号： C12M47/02 , A61M1/3678 , B01D21/0045 , B01D21/283 , B06B1/06 , C12M33/08 , C12M47/10
摘要： An acoustophoresis device made up of modular components is disclosed. Several modules are disclosed herein, including ultrasonic transducer modules, input/output modules, collection well modules, and various connector modules. These permit different systems to be constructed that have appropriate fluid dynamics for separation of particles, such as biological cells, from a fluid.
摘要翻译： 公开了一种由模块化部件组成的消声装置。 本文公开了多个模块，包括超声换能器模块，输入/输出模块，收集井模块和各种连接器模块。 这些允许构建具有用于从流体分离颗粒（例如生物细胞）的适当流体动力学的不同系统。
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70.发明公开
公开(公告)号：EP2825279A4
公开(公告)日：2016-03-09
申请号：EP13760840
申请日：2013-03-15
申请人： FLODESIGN SONICS INC
CPC分类号： B01D43/00 , B06B1/0644 , C12M47/02
摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.
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