公开(公告)号：EP2747890A4

公开(公告)日：2015-04-22

申请号：EP12833859

申请日：2012-08-22

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  MITCHELL ERIC ,  CARMICHAEL JOEY ,  MEALEY DANE ,  DIONNE JASON

IPC分类号： B03B5/00 ,  B06B3/00 ,  B07C5/00 ,  C11C1/00 ,  C12N1/06 ,  C12P7/64

CPC分类号： C12M47/06 ,  C12M21/02 ,  C12M33/08 ,  C12M47/10 ,  C12N1/066 ,  C12N13/00

公开(公告)号：EP2582631A4

公开(公告)日：2016-05-25

申请号：EP11796470

申请日：2011-06-16

申请人： FLODESIGN SONICS INC

发明人： RIETMAN EDWARD A ,  LIPKENS BART

IPC分类号： C02F1/44 ,  B01D63/06 ,  C02F1/36

CPC分类号： C02F1/441 ,  B01D63/06 ,  B01D63/065 ,  B01D2311/26 ,  B01D2313/24 ,  B01D2313/36 ,  B01D2321/2075 ,  C02F1/34 ,  C02F1/36 ,  C02F2201/002 ,  Y02A20/131

摘要： Disclosed herein are systems and methods for desalination of salt water based on an engineered acoustic field that causes constructive and destructive interference at pre-computed spatial positions. The engineered acoustic field can cause high-pressure and low-pressure regions where desalination membranes are located. The induced pressure from the acoustic field can force pure water through the membranes leaving ionic and dissolved molecular species behind.

公开(公告)号：EP2748301A4

公开(公告)日：2015-08-05

申请号：EP12826150

申请日：2012-08-22

申请人： FLODESIGN SONICS INC

发明人： DIONNE JASON ,  KING JEFF ,  LIPKENS BART ,  RIETMAN EDWARD A

IPC分类号： C12N1/12 ,  C12M1/26

CPC分类号： B06B1/0625 ,  C12M33/00 ,  C12M33/12 ,  C12M33/22 ,  C12M47/02

公开(公告)号：EP2953700A4

公开(公告)日：2017-02-15

申请号：EP14749278

申请日：2014-02-07

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  MASI LOUIS ,  KOWALSKI III STANLEY ,  PRESZ WALTER M JR ,  DIONNE JASON ,  DUTRA BRIAN ,  MERCADO ARI ,  KENNEDY III THOMAS ,  MARTIN ARTHUR

IPC分类号： B01D17/04 ,  C02F1/36 ,  C02F1/40

CPC分类号： C12M47/06 ,  B01D21/283 ,  C12M29/10 ,  C12M33/08 ,  C12M47/02

摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor. The bioreactor includes a reaction vessel, an agitator, a feed inlet, and an outlet. A filtering device is included that has an inlet, a flow chamber and a sleeve surrounding the flow chamber, where the sleeve includes the ultrasonic transducer.

公开(公告)号：EP2988842A4

公开(公告)日：2017-01-25

申请号：EP14787587

申请日：2014-04-25

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  MERCADO ARI ,  MARTIN ARTHUR ,  MASI LOUIS ,  DIONNE JASON

IPC分类号： B01D11/00

CPC分类号： B01D21/00 ,  B01D11/0223 ,  B01D11/0265 ,  B01D21/283 ,  B01D2221/10 ,  G01N33/15

公开(公告)号：EP3164488A4

公开(公告)日：2018-04-11

申请号：EP15814616

申请日：2015-07-02

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  MCCARTHY BRIAN ,  BARNES JASON ,  MEALEY DANE ,  ROSS JOHNSRUD BEN ,  PRESZ JR WALTER M ,  CHITALE KEDAR

IPC分类号： A61M1/36 ,  B01D21/00 ,  B01D21/28 ,  B06B1/06 ,  C12M1/00 ,  C12M1/26

CPC分类号： B01D21/283 ,  B01D21/0045

摘要： An acoustophoresis device which includes a substantially vertical flow path of the fluid mixture in order to improve separation of particles/secondary fluid from a primary fluid is disclosed. The vertical flow path reduces velocity non-uniformities in the acoustic chamber resulting from gravity forces. The device includes an acoustic chamber in which multidimensional acoustic standing waves are generated. The fluid can be introduced into the acoustic chamber using a dump diffuser in which a plurality of inlets enter near the bottom of the acoustic chamber such that flow symmetry reduces both, gravity driven flow non-uniformities, and any flow interference effects between inlet mixture flow into the acoustic chamber and the continuous gravity driven particle cluster drop out.

公开(公告)号：EP3019606A4

公开(公告)日：2017-04-05

申请号：EP14823682

申请日：2014-07-11

申请人： FLODESIGN SONICS INC

发明人： KENNEDY III THOMAS J ,  LIPKENS BART ,  MASI LOUIS ,  KOWALSKI III STANLEY ,  LEIDEL CHRIS

IPC分类号： C12N13/00 ,  B06B1/02 ,  B06B1/06 ,  C07K1/14 ,  C12M1/00 ,  C12P21/02

CPC分类号： C12N13/00 ,  B06B1/0238 ,  B06B1/0648 ,  B06B2201/76 ,  C07K1/145 ,  C12M47/02 ,  C12P21/02

摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.

摘要翻译： 在生物反应器的生长体积内建立一系列多维声驻波。 声波驻波被用于将细胞培养物保持在适当位置，因为营养液流流过细胞培养物。 通过营养液流收集由细胞培养产生的生物分子，并在细胞培养物的下游分离。

公开(公告)号：EP2903715A4

公开(公告)日：2016-10-05

申请号：EP13844181

申请日：2013-09-13

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  DIONNE JASON ,  PRESZ JR WALTER ,  KENNEDY III THOMAS J

IPC分类号： B01D17/04 ,  C02F1/36 ,  C02F1/40

CPC分类号： B06B1/06 ,  B06B2201/70 ,  C12M47/02

摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

公开(公告)号：EP2825279A4

公开(公告)日：2016-03-09

申请号：EP13760840

申请日：2013-03-15

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  DIONNE JASON ,  KENNEDY III THOMAS J ,  MASI LOUIS ,  KOWALSKI III STANLEY

IPC分类号： B01D17/04 ,  B01D43/00 ,  C02F1/36 ,  C02F1/40

CPC分类号： B01D43/00 ,  B06B1/0644 ,  C12M47/02

摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.

公开(公告)号：EP2748110A4

公开(公告)日：2015-05-27

申请号：EP12825592

申请日：2012-08-22

申请人： FLODESIGN SONICS INC

发明人： DIONNE JASON ,  LIPKENS BART ,  RIETMAN EDWARD A

IPC分类号： B01D21/28 ,  B03B5/00 ,  C02F1/36

CPC分类号： B03B5/00 ,  B01D21/283 ,  C02F1/36 ,  C12M47/02

摘要： A flow chamber is provided through which is flowed a mixture of a fluid and a particulate. The flow chamber comprises at least one multi-phase water inlet through which multi-phase water enters the flow chamber, a water outlet through which water exits the flow chamber, a solids outlet through which particles having a density at or above a pre-defined threshold exit the flow chamber, and a low density outlet through which particles having a density below the pre-defined threshold exit the flow chamber. Also provided are one or more ultrasonic transducers and one or more reflectors corresponding to each transducer to acoustically filter the fluid and cause particles/fluid to be selectively diverted to one of the outlets. Related apparatus, systems, techniques and articles are also described.