公开(公告)号：EP2953700A4

公开(公告)日：2017-02-15

申请号：EP14749278

申请日：2014-02-07

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  MASI LOUIS ,  KOWALSKI III STANLEY ,  PRESZ WALTER M JR ,  DIONNE JASON ,  DUTRA BRIAN ,  MERCADO ARI ,  KENNEDY III THOMAS ,  MARTIN ARTHUR

IPC分类号： B01D17/04 ,  C02F1/36 ,  C02F1/40

CPC分类号： C12M47/06 ,  B01D21/283 ,  C12M29/10 ,  C12M33/08 ,  C12M47/02

摘要： A perfusion bioreactor includes at least one ultrasonic transducer that can acoustically generate a multi-dimensional standing wave. The standing wave can be used to retain cells in the bioreactor, and can also be utilized to dewater or further harvest product from the waste materials produced in a bioreactor. The bioreactor includes a reaction vessel, an agitator, a feed inlet, and an outlet. A filtering device is included that has an inlet, a flow chamber and a sleeve surrounding the flow chamber, where the sleeve includes the ultrasonic transducer.

公开(公告)号：EP2988842A4

公开(公告)日：2017-01-25

申请号：EP14787587

申请日：2014-04-25

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  MERCADO ARI ,  MARTIN ARTHUR ,  MASI LOUIS ,  DIONNE JASON

IPC分类号： B01D11/00

CPC分类号： B01D21/00 ,  B01D11/0223 ,  B01D11/0265 ,  B01D21/283 ,  B01D2221/10 ,  G01N33/15

公开(公告)号：EP3019606A4

公开(公告)日：2017-04-05

申请号：EP14823682

申请日：2014-07-11

申请人： FLODESIGN SONICS INC

发明人： KENNEDY III THOMAS J ,  LIPKENS BART ,  MASI LOUIS ,  KOWALSKI III STANLEY ,  LEIDEL CHRIS

IPC分类号： C12N13/00 ,  B06B1/02 ,  B06B1/06 ,  C07K1/14 ,  C12M1/00 ,  C12P21/02

CPC分类号： C12N13/00 ,  B06B1/0238 ,  B06B1/0648 ,  B06B2201/76 ,  C07K1/145 ,  C12M47/02 ,  C12P21/02

摘要： A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.

摘要翻译： 在生物反应器的生长体积内建立一系列多维声驻波。 声波驻波被用于将细胞培养物保持在适当位置，因为营养液流流过细胞培养物。 通过营养液流收集由细胞培养产生的生物分子，并在细胞培养物的下游分离。

公开(公告)号：EP2825279A4

公开(公告)日：2016-03-09

申请号：EP13760840

申请日：2013-03-15

申请人： FLODESIGN SONICS INC

发明人： LIPKENS BART ,  DIONNE JASON ,  KENNEDY III THOMAS J ,  MASI LOUIS ,  KOWALSKI III STANLEY

IPC分类号： B01D17/04 ,  B01D43/00 ,  C02F1/36 ,  C02F1/40

CPC分类号： B01D43/00 ,  B06B1/0644 ,  C12M47/02

摘要： A system having improved trapping force for acoustophoresis is described where the trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The transducer includes a ceramic crystal. The crystal may be directly exposed to fluid flow. The crystal may be air backed, resulting in a higher Q factor.