公开(公告)号：EP3000320A1

公开(公告)日：2016-03-30

申请号：EP15190199.8

申请日：2008-05-16

申请人： The Brigham and Women's Hospital, Inc.

发明人： Schlossmacher, Michael ,  Cullen, Valerie ,  Shihabuddin, Lamya ,  Cheng, Seng H.

IPC分类号： A01N43/62 ,  A61K48/00 ,  A61K38/47 ,  A61K38/48

CPC分类号： A61K38/4873 ,  A61K31/00 ,  A61K31/047 ,  A61K31/4353 ,  A61K31/436 ,  A61K31/7088 ,  A61K38/13 ,  A61K38/1709 ,  A61K38/47 ,  A61K38/488 ,  A61K45/06 ,  A61K48/005 ,  A61K2300/00 ,  C12Y302/01045 ,  C12Y304/22041 ,  C12Y304/23005

摘要： This invention relates generally to treating synucleopathies in subjects that are not clinically diagnosed with a lysosomal storage disease, as well as associated methods of making medicaments and screening methods.

摘要翻译： 本发明一般涉及在临床诊断患有溶酶体贮积病的受试者中以及相关的制备药物和筛选方法的方法治疗突触核蛋白病。

公开(公告)号：EP2970890A1

公开(公告)日：2016-01-20

申请号：EP14774723.2

申请日：2014-03-11

申请人： The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： KARP, Jeffrey, Michael ,  YIN, Xiaolei ,  SUCCI, Marc David ,  LANGER, Robert, Samuel

IPC分类号： C12N5/02

CPC分类号： C12N5/068 ,  A61K31/19 ,  A61K31/506 ,  C12N5/0679 ,  C12N2501/065 ,  C12N2501/11 ,  C12N2501/155 ,  C12N2501/415 ,  C12N2501/42 ,  C12N2501/727 ,  C12N2501/73 ,  C12N2513/00

摘要： Described are cell culture solutions and systems for epithelial stem cell and organoid cultures, formation of epithelial constructs and uses of the same in transplantation. A single layer of epithelial cells that actively self-renews and is organized into crypts and villi clothes the intestine. It has been recently shown that the renewal of intestinal epithelium is driven by Lgr5+ intestinal stem cells (ISC) that reside at the base of these crypts (Barker et al., 2007). Lgr5+ stem cells can be isolated and cultured in vitro to form organoids containing crypt-vcllus structures that recapitulates the native intestinal epithelium (Sato et al., 2009).

公开(公告)号：EP2961849A2

公开(公告)日：2016-01-06

申请号：EP14715725.9

申请日：2014-02-27

申请人： The Broad Institute, Inc. ,  President and Fellows of Harvard College ,  The Brigham and Women's Hospital, Inc. ,  Massachusetts Institute of Technology

发明人： REGEV, Aviv ,  KUCHROO, Vijay ,  PARK, Hongkun ,  YOSEF, Nir ,  SHALEK, Alexander, K. ,  GAUBLOMME, Jellert ,  JOLLER, Nicole C. ,  WU, Chuan ,  ANDERSON, Ana, Carrizosa

IPC分类号： C12Q1/68 ,  A61K39/39 ,  C12N5/0783

CPC分类号： C12N5/0636 ,  A61K31/12 ,  A61K31/198 ,  A61K31/37 ,  A61K31/4745 ,  A61K31/66 ,  A61K31/661 ,  A61K31/7076 ,  A61K31/7088 ,  A61K31/739 ,  A61K33/00 ,  A61K33/06 ,  A61K33/24 ,  A61K38/1767 ,  A61K38/1866 ,  A61K38/191 ,  A61K38/363 ,  A61K38/4866 ,  A61K48/00 ,  C07K16/28 ,  C07K2317/76 ,  C12N5/0637 ,  C12N15/113 ,  C12N2310/14 ,  C12N2320/30 ,  C12N2501/15 ,  C12N2501/2301 ,  C12N2501/2306 ,  C12N2501/2323 ,  C12N2501/25 ,  C12N2501/90 ,  C12Q1/6881 ,  C12Q2600/112 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Y304/21069 ,  G01N33/56972 ,  G01N2570/00 ,  G01N2800/56

摘要： This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.

公开(公告)号：EP2384753B1

公开(公告)日：2016-01-06

申请号：EP10011481.8

申请日：2004-08-30

申请人： The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College

发明人： Cuny, Gregory, D. ,  Yuan, Junying ,  Jagtap, Prakash ,  Degterev, Alexei

IPC分类号： A61K31/4178 ,  A61K31/422 ,  A61P25/28

CPC分类号： C07D409/06 ,  C07D403/06 ,  C07D405/06 ,  C07D413/06 ,  C07D471/04

公开(公告)号：EP2958591A2

公开(公告)日：2015-12-30

申请号：EP14754905.9

申请日：2014-02-12

申请人： The Brigham and Women's Hospital, Inc.

发明人： GOLDMAN, Aaron ,  KULKARNI, Ashish ,  SENGUPTA, Shiladitya

IPC分类号： A61K39/395

CPC分类号： A61K31/506 ,  A61K31/337 ,  A61K31/517 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/6907 ,  C12N15/1138 ,  C12N2310/14 ,  G01N33/57484 ,  G01N2500/10 ,  G01N2800/52 ,  A61K2300/00

摘要： The compositions and methods described herein relate to the treatment of cancer, e.g. by reducing the regression of cancer cells from regressing into cancer stem cell-like phenotypes and/or reducing the development of drug-resistant cancer cells. In some embodiments, the compositions and methods relate to inhibitors of PI3K pathway kinases and Src family kinases.

公开(公告)号：EP2408466B1

公开(公告)日：2015-10-21

申请号：EP10754107.0

申请日：2010-03-18

申请人： The Brigham and Women's Hospital, Inc. ,  Cincinnati Children's Hospital Medical Center

发明人： DUFFIELD, Jeremy ,  LANG, Richard A.

IPC分类号： A61K38/16 ,  A61P43/00 ,  A61P13/12 ,  A61P1/18

CPC分类号： A61K38/16 ,  G01N33/6872 ,  G01N33/6893

公开(公告)号：EP2155248B1

公开(公告)日：2015-06-10

申请号：EP08742787.8

申请日：2008-04-11

申请人： The Brigham and Women's Hospital, Inc.

发明人： FRANK, Markus, H. ,  FRANK, Natasha, Y. ,  SAYEGH, Mohamed, H.

IPC分类号： A61K39/395 ,  C07K16/18

CPC分类号： A61K47/6851 ,  A61K31/713 ,  A61K38/47 ,  A61K2039/505 ,  C07K16/18 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/732 ,  C07K2317/734 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/3513 ,  C12N2320/32 ,  C12Y302/02022 ,  G01N33/57492 ,  G01N2333/705

摘要： The invention relates to methods for treating a subject by manipulating ABCB5 on a cell as well as related products. The methods include methods of treating cancer using ABCB5 binding molecules such as antibodies and fragments thereof.

公开(公告)号：EP1735445B1

公开(公告)日：2015-05-27

申请号：EP05732272.9

申请日：2005-03-14

申请人： THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ,  Beth Israel Deaconess Medical Center

发明人： KUCHROO, Vijay, K. ,  CHAKRAVARTI, Sumone ,  STROM, Terry ,  ZHENG, Xin Xiao ,  MEYERS, Jennifer

IPC分类号： C07K14/705 ,  C07K19/00 ,  A61K38/17 ,  G01N33/53

CPC分类号： C07K16/2803 ,  A61K38/00 ,  A61K38/177 ,  A61K39/39541 ,  A61K39/3955 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/70503 ,  C07K16/2875 ,  C07K2319/00 ,  C12N2310/14 ,  G01N33/5768 ,  G01N33/6812 ,  G01N33/6845 ,  G01N33/6863 ,  G01N33/6872 ,  G01N2500/02 ,  G01N2800/24 ,  A61K2300/00

公开(公告)号：EP2872493A2

公开(公告)日：2015-05-20

申请号：EP13817021.2

申请日：2013-07-12

申请人： Indiana University Research and Technology Corporation ,  The Brigham and Women's Hospital, Inc. ,  The University of Massachusetts

发明人： ANDROPHY, Elliot J. ,  CHERRY, Jonathon J. ,  CUNY, Gregory D. ,  GLICKSMAN, Marcie A.

IPC分类号： C07D261/06 ,  C07D413/12 ,  A61K31/42 ,  A61P21/00

CPC分类号： C07D493/04 ,  C07C311/37 ,  C07C2601/08 ,  C07C2603/20 ,  C07D213/75 ,  C07D215/227 ,  C07D215/44 ,  C07D221/10 ,  C07D231/14 ,  C07D233/88 ,  C07D239/47 ,  C07D239/82 ,  C07D261/06 ,  C07D261/14 ,  C07D261/18 ,  C07D263/48 ,  C07D267/14 ,  C07D277/46 ,  C07D285/135 ,  C07D401/04 ,  C07D405/04 ,  C07D405/12 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07K14/47

摘要： Disclosed herein are compositions and methods for treatment of spinal muscular atrophy (SMA). In certain embodiments, compounds are provided that increase full-length survival of motor neuron (SMN) protein production by an SMN2 gene.

摘要翻译： 本文公开了用于治疗脊髓性肌萎缩（SMA）的组合物和方法。 在某些实施方案中，提供了增加SMN2基因产生的运动神经元（SMN）蛋白质生产的全长存活的化合物。

公开(公告)号：EP2828289A1

公开(公告)日：2015-01-28

申请号：EP13764561.0

申请日：2013-03-11

申请人： The Brigham and Women's Hospital, Inc. ,  President and Fellows of Harvard College

发明人： LEE, Richard T. ,  LOFFREDO, Francesco ,  PANCOAST, James ,  STEINHAUSER, Matthew ,  WAGERS, Amy

IPC分类号： C07K14/475 ,  A61K39/00 ,  A61P9/00

摘要： The technology described herein relates to treatments for, e.g., diastolic heart failure, cardiac hypertrophy, and related conditions.