公开(公告)号：EP3027737B1

公开(公告)日：2018-12-26

申请号：EP14744087.9

申请日：2014-07-25

Applicant: F. Hoffmann-La Roche AG

Inventor： BAILLY, Jacques ,  CIAMPI, Osele ,  GRAF, Martin ,  IACONE, Roberto ,  PATSCH, Christoph

IPC: C12N5/071

CPC classification number: C12N5/0687 ,  C12N2500/25 ,  C12N2500/38 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/392 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2506/45

Abstract: This application relates to a method for differentiating pluripotent stem cells (PSCs) into multi-competent renal precursor cells expressing Six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into defined renal precursor cells expressing Six2 and podocytes based on linked steps of chemically defined medium inductions.

公开(公告)号：EP3411475A1

公开(公告)日：2018-12-12

申请号：EP17748355.9

申请日：2017-02-06

Applicant: President and Fellows of Harvard College ,  The General Hospital Corporation

Inventor： SHAH, Nisarg, J. ,  SHIH, Ting-Yu ,  MAO, Angelo ,  MOONEY, David, J. ,  SCADDEN, David, T.

IPC: C12N5/0797 ,  C12N5/078

CPC classification number: C12N5/0647 ,  C12N2501/155 ,  C12N2533/74

Abstract: Disclosed are compositions and related methods of recapitulating bone marrow stroma using scaffold materials (e.g., a porous alginate hydrogel scaffold) containing one or more cellular differentiation factors, and one or more growth factors. Such methods and compositions promote the formation of an ectopic nodule or site that can improve transplanted cell engraftment and selectively drive the development of lymphocytes and the reconstitution of the adaptive immunity after hematopoietic stem cell transplant.

公开(公告)号：EP2898065B1

公开(公告)日：2018-11-14

申请号：EP13766954.5

申请日：2013-09-23

Applicant: Plasticell Limited

Inventor： TARUNINA, Marina ,  CHOO, Yen ,  MYLVAGANAM, Jeyakumar ,  WATSON, Thomas ,  ROSEELL, Meritxell ,  HOOK, Lilian ,  HERNANDEZ, Diana

IPC: C12N5/077 ,  A61K35/35

CPC classification number: C12N5/0653 ,  A61K35/35 ,  C12N2500/24 ,  C12N2500/25 ,  C12N2501/01 ,  C12N2501/04 ,  C12N2501/155 ,  C12N2501/33 ,  C12N2502/1352 ,  C12N2506/1384

Abstract: The present invention relates to brown adipose tissue (BAT) cells derived from adult stern or progenitor cells, derived from adult white fat tissue (WAT), as well as to methods for deriving such cells.

公开(公告)号：EP3384011A1

公开(公告)日：2018-10-10

申请号：EP16804820.5

申请日：2016-12-01

Applicant: Katholieke Universiteit Leuven ,  Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)

Inventor： VERFAILLIE, Cathérine ,  BOON, Ruben ,  SANCHO BRU, Pau ,  COL LOPERENA, Mar ,  PEREA SANCHEZ, Luis

IPC: C12N5/075 ,  C12N5/077

CPC classification number: C12N5/067 ,  C12N5/0672 ,  C12N2501/113 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/999 ,  C12N2506/45 ,  C12N2513/00

Abstract: The invention is directed to methods for culturing cells so that the cells are induced to differentiate into cells that express a hepatic stellate phenotype. The invention is also directed to cells produced by the methods of the invention. The cells are useful, among other applications, for treatment of liver deficiencies, liver metabolism studies, and liver toxicity studies, fibrogenic studies, or to support hepatocyte function in co-culture setting.

公开(公告)号：EP2785359B1

公开(公告)日：2018-08-29

申请号：EP12854438.4

申请日：2012-11-30

Applicant: Astellas Institute for Regenerative Medicine

Inventor： LANZA, Robert ,  KIMBREL, Erin, Anne ,  CHU, Jianlin ,  KOURIS, Nicholas, Arthur

IPC: A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/36 ,  A61K35/407 ,  C12N5/0789 ,  C12N5/077 ,  C12N5/071 ,  A61K35/39 ,  C12N5/0775

CPC classification number: A61K35/28 ,  A61K35/30 ,  A61K35/34 ,  A61K35/36 ,  A61K35/39 ,  A61K35/407 ,  A61K48/00 ,  C12N5/0647 ,  C12N5/0652 ,  C12N5/0668 ,  C12N5/0692 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/26 ,  C12N2502/1171 ,  C12N2506/02 ,  C12N2506/11 ,  C12N2506/28 ,  C12N2533/54 ,  A61K2300/00

Abstract: The present invention generally relates to novel preparations of mesenchymal stromal cells (MSCs) derived from hemangioblasts, methods for obtaining such MSCs, and methods of treating a pathology using such MSCs. The methods of the present invention produce substantial numbers of MSCs having a potency-retaining youthful phenotype, which are useful in the treatment of pathologies.

公开(公告)号：EP2504425B1

公开(公告)日：2018-08-29

申请号：EP10833936.7

申请日：2010-11-24

Applicant: University of Connecticut

Inventor： DEALY, Caroline, N. ,  KOSHER, Robert, A.

IPC: C12N5/077 ,  C12N5/0735

CPC classification number: C12N5/0655 ,  C12N2501/155 ,  C12N2506/02 ,  C12N2506/45

Abstract: The invention relates to culture systems, methods, and conditions that allow pluripotent undifferentiated hESCs or iPSCs to progressively and uniformly differentiate into cells of the chondrogenic lineage.

公开(公告)号：EP2456858B1

公开(公告)日：2018-08-29

申请号：EP10802710.3

申请日：2010-07-19

Applicant: Janssen Biotech, Inc.

Inventor： XU, Jean

IPC: C12N5/0735 ,  C12N5/071 ,  C12N5/02 ,  A61K35/39 ,  A61K35/12 ,  A61P3/10

CPC classification number: C12N5/0676 ,  A61K35/12 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/117 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/19 ,  C12N2501/385 ,  C12N2501/41 ,  C12N2501/415 ,  C12N2506/02 ,  C12N2533/90

Abstract: The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells capable of producing insulin following transplantation into an animal.

公开(公告)号：EP2580320B1

公开(公告)日：2018-08-01

申请号：EP11796321.5

申请日：2011-06-14

Applicant: The Scripps Research Institute

Inventor： EFE, Jem, A. ,  KIM, Janghwan ,  ZHU, Saiyong ,  HILCOVE, Simon ,  DING, Sheng

IPC: A61K35/30 ,  A61K35/33 ,  A61K35/34 ,  A61K35/39 ,  C12N15/85 ,  C12N5/0793 ,  C12N5/077 ,  C12N5/071 ,  C12N5/073 ,  C12N5/074 ,  C12N5/0797

CPC classification number: C12N5/0676 ,  A61K35/30 ,  A61K35/33 ,  A61K35/34 ,  A61K35/39 ,  C12N5/0602 ,  C12N5/0603 ,  C12N5/0607 ,  C12N5/0618 ,  C12N5/0619 ,  C12N5/0623 ,  C12N5/0657 ,  C12N5/0678 ,  C12N15/85 ,  C12N2501/01 ,  C12N2501/155 ,  C12N2501/235 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/605 ,  C12N2501/606 ,  C12N2501/727 ,  C12N2506/02 ,  C12N2506/08 ,  C12N2506/1307 ,  C12N2510/00

Abstract: Methods and compositions for transdifferentiation of an animal cell from (i) a first pluripotent cell fate to a second nonpluripotent cell fate or (ii) from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate.

公开(公告)号：EP3348631A1

公开(公告)日：2018-07-18

申请号：EP16844465.1

申请日：2016-09-08

Applicant: Sumitomo Dainippon Pharma Co., Ltd. ,  SUMITOMO CHEMICAL COMPANY, LIMITED ,  RIKEN

Inventor： ANDO, Satoshi ,  KURODA, Takao ,  SASAI, Yoshiki

IPC: C12N5/071 ,  A61K35/30 ,  C12N5/0735 ,  C12N5/074 ,  C12N5/0793 ,  C12N5/10 ,  C12Q1/02 ,  A61K35/545

CPC classification number: C12N5/0621 ,  A61K35/30 ,  A61K35/545 ,  C12N5/10 ,  C12N2500/90 ,  C12N2501/115 ,  C12N2501/155 ,  C12N2501/41 ,  C12N2501/727 ,  C12N2506/45 ,  C12N2513/00 ,  C12Q1/02 ,  G01N33/5014 ,  G01N33/5058

Abstract: The present invention provides a production method of a retinal cell or retinal tissue, including the following steps:
(1) a first step of culturing mammalian pluripotent stem cells in the absence of a feeder cell for a period not exceeding 30 days in a medium comprising 1) a factor for maintaining an undifferentiated state and 2) an MEK inhibitor,
(2) a second step of culturing the cells obtained in the first step in suspension to form a cell aggregate, and
(3) a third step of culturing the aggregate obtained in the second step in suspension in the presence of a BMP signal transduction pathway activating substance to obtain an aggregate containing retinal cells or a retinal tissue.

公开(公告)号：EP3347451A1

公开(公告)日：2018-07-18

申请号：EP16778499.0

申请日：2016-09-09

Applicant: The General Hospital Corporation

Inventor： REN, Xi ,  OTT, Harald C.

IPC: C12N5/071 ,  C12M3/00

CPC classification number: C12N5/0697 ,  C12M21/08 ,  C12M25/14 ,  C12M41/48 ,  C12N5/0688 ,  C12N2500/02 ,  C12N2500/25 ,  C12N2501/01 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/135 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/17 ,  C12N2501/39 ,  C12N2501/415 ,  C12N2502/1388 ,  C12N2502/27 ,  C12N2502/28 ,  C12N2506/45 ,  C12N2533/92

Abstract: A method for vascular regeneration comprises delivering endothelial cells to a lung scaffold, delivering perivascular cells to the lung scaffold, and providing a multiphase culture program to the scaffold. The multiphase culture program comprises a first phase including delivering an angiogenic medium, e.g., having 40-100 ng/ml of pro-angiogenic factors, and a second phase including delivering a stabilization medium, e.g., having 0.5-2% of serum and 1-20 ng/ml of angiogenic factors.