公开(公告)号：EP2673263A1

公开(公告)日：2013-12-18

申请号：EP12705744.6

申请日：2012-02-10

申请人： Allergan, Inc.

发明人： BEARD, Richard L. ,  DONELLO, John E. ,  GARST, Michael E. ,  VISWANATH, Veena ,  DUONG, Tien T.

IPC分类号： C07D217/24 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14 ,  A61K31/4725 ,  A61P27/02

CPC分类号： C07D217/24 ,  C07D401/06 ,  C07D401/14 ,  C07D405/14

摘要： The present invention relates to novel 1-(1-Oxo-1,2,3,4-tetrahydroisoquinolin-7-yl)urea derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.

公开(公告)号：EP2646030A1

公开(公告)日：2013-10-09

申请号：EP11794290.4

申请日：2011-11-18

申请人： Allergan, Inc.

发明人： BEARD, Richard L. ,  DONELLO, John E. ,  VISWANATH, Veena ,  GARST, Michael E.

IPC分类号： A61K31/472 ,  A61K31/4725 ,  A61P27/02 ,  A61P29/00

CPC分类号： A61K31/472 ,  A61K31/4725

摘要： The present invention relates to a method of treating a disorder associated with modulation of the FPRL-1 receptor which comprises administering a therapeutically effective amount of a pharmaceutical composition comprising a 3,4-dihydroisoquinolin-2(1H)-yl-3-phenylurea derivative.

公开(公告)号：EP2640382A1

公开(公告)日：2013-09-25

申请号：EP11785262.4

申请日：2011-11-10

申请人： Allergan, Inc.

发明人： DIBAS, Mohammed I. ,  DONELLO, John E. ,  GIL, Daniel W.

IPC分类号： A61K31/4174 ,  A61P27/06

CPC分类号： A61K31/4174 ,  A61K9/0048 ,  A61K9/08

摘要： The present invention relates to method of lowering intraocular pressure in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, or enantiomers thereof, or tautomers thereof, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：EP2616066A1

公开(公告)日：2013-07-24

申请号：EP11760958.6

申请日：2011-09-16

申请人： Allergan, Inc.

发明人： DIBAS, Mohammed I. ,  GIL, Daniel W. ,  CHOW, Ken ,  WANG, Liming ,  GARST, Michael E. ,  DONELLO, John E.

IPC分类号： A61K31/4174 ,  A61P27/06

CPC分类号： A61K31/4174 ,  A61K9/0014 ,  A61K31/4164 ,  C07D233/64 ,  Y10S514/912

摘要： The present invention relates to method of treating retinal diseases in a subject in need of such treatment, which comprises administering a therapeutically effective amount of a composition comprising a ester pro-drugs of [3-(1-(1H-imidazol-4-yl)ethyl)-2-methylphenyl] methanol, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals.

公开(公告)号：EP2525793A2

公开(公告)日：2012-11-28

申请号：EP11702342.4

申请日：2011-01-21

申请人： Allergan, Inc.

发明人： DONELLO, John E. ,  GIL, Daniel W. ,  DIBAS, Mohammed I.

IPC分类号： A61K31/4184 ,  A61K9/08 ,  A61P27/06

CPC分类号： A61K9/0048 ,  A61K31/4184

摘要： The present invention provides a method of lowering intraocular pressure which comprises administering a therapeutically effective amount of a pharmaceutical composition comprising 4-bromo-5-(2-imidazolin-2-ylamino)benzimidazole, or a salt thereof to the affected eye of a patient, as a single dose, wherein the affected eye has an intraocular pressure less than the baseline intraocular pressure for at least eight (8) hours.

摘要翻译： 本发明提供了一种降低眼内压的方法，其包括向患者的受影响的眼睛施用治疗有效量的包含4-溴-5-（2-咪唑啉-2-基氨基）苯并咪唑或其盐的药物组合物 作为单剂量，其中受影响的眼睛具有小于基线眼压的眼内压至少八（8）小时。

公开(公告)号：EP2477624A1

公开(公告)日：2012-07-25

申请号：EP10757359.4

申请日：2010-09-15

申请人： Allergan, Inc.

发明人： DONELLO, John E. ,  LUHRS, Lauren M.B.

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/4409 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/4709 ,  A61P25/14 ,  A61P25/08 ,  A61P25/00 ,  A61P21/00 ,  A61P21/02

CPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/4409 ,  A61K31/4439 ,  A61K31/4523 ,  A61K31/4535 ,  A61K31/4545 ,  A61K31/4709

摘要： Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula (I).

公开(公告)号：EP2453890A1

公开(公告)日：2012-05-23

申请号：EP10735143.9

申请日：2010-07-16

申请人： Allergan, Inc.

发明人： STAUBLI, Ursula V. ,  DONELLO, John E.

IPC分类号： A61K31/40 ,  A61K31/4025 ,  A61K31/4409 ,  A61K31/4427 ,  A61K31/4523 ,  A61K31/4709 ,  A61P25/00 ,  A61P25/28 ,  A61P25/16 ,  A61K45/06

摘要： Disclosed herein is a pharmaceutical composition comprising a cholinesterase inhibitor and compound of the following formula: The composition is effective for treating cognitive disorders, and methods of treating such disorders using the composition are also disclosed.

公开(公告)号：EP2124920A1

公开(公告)日：2009-12-02

申请号：EP07855143.9

申请日：2007-12-13

申请人： ALLERGAN, INC.

发明人： GIL, Daniel W. ,  DONELLO, John E.

IPC分类号： A61K31/195 ,  A61K31/197 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4178 ,  A61K45/00 ,  A61K31/4709 ,  A61P29/00 ,  A61P29/02

CPC分类号： A61K45/06 ,  A61K31/195 ,  A61K31/197 ,  A61K31/4164 ,  A61K31/4174 ,  A61K31/4709 ,  A61K2300/00

摘要： Disclosed herein is a pharmaceutical composition comprising a pain- relieving anticonvulsant and an alpha-2B receptor agonist. The composition is effective for treating chronic pain, and methods of treating chronic pain using the composition and the compounds comprising it are also disclosed.