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公开(公告)号：EP2770989B1
公开(公告)日：2018-09-05
申请号：EP12781009.1
申请日：2012-10-23
申请人： ALLERGAN, INC.
IPC分类号： A61K31/17 , C07C275/28 , A61P27/02 , C07K5/062 , C07C275/30 , A61K31/197 , A61K31/216 , A61K31/4045 , A61K31/417 , C07D233/64 , C07D209/20 , C07K5/078 , C07K5/072 , A61K31/198
CPC分类号： A61K31/417 , A61K31/17 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/4045 , C07C275/30 , C07C317/42 , C07C317/50 , C07C323/44 , C07C323/60 , C07D209/20 , C07D233/64 , C07K5/06017 , C07K5/06034 , C07K5/06052 , C07K5/0606 , C07K5/06113 , C07K5/06147 , C07K5/06156 , Y02A50/401
摘要： The present invention relates to novel amide derivatives of N-urea substituted amino acids, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
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2.发明授权
公开(公告)号：EP2820010B1
公开(公告)日：2018-05-09
申请号：EP13711995.4
申请日：2013-03-01
申请人： ALLERGAN, INC.
发明人： YUAN, Haiqing , BEARD, Richard L. , LIU, Xiaoxia , DONELLO, John E. , VISWANATH, Veena , GARST, Michael E.
IPC分类号： C07D405/12 , C07D405/14 , A61K31/443 , A61P29/00
CPC分类号： C07D307/78 , A61P29/00 , C07D307/82 , C07D405/12 , C07D405/14
摘要： The present invention relates to benzofuran-2-sulfonamide derivatives with the following formula: or pharmaceutically acceptable salts thereof. The derivatives are useful as modulators of chemokine receptors.
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公开(公告)号：EP2855508B1
公开(公告)日：2018-02-14
申请号：EP13727787.7
申请日：2013-05-30
申请人： ALLERGAN, INC.
发明人： PETTIT, Simon N. , JONES, Andrew D. , FRYDRYCH, Catherine Simone V. , CARLING, William R. , GARST, Michael E.
IPC分类号： C07K7/64
摘要： The present invention relates to novel cyclosporin analogs, processes for preparing them, pharmaceutical compositions containing them, and methods for using these analogs and the compositions containing them for the treatment of medical conditions, including but not limited to ocular conditions such as dry eye.
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4.发明授权ESTER PRO-DRUGS OF [3-(1-(1H-IMIDAZOL-4-YL)ETHYL)-2-METHYLPHENYL]METHANOL FOR TREATING SKIN DISEASES AND CONDITIONS 有权酯前药的[3-（1-（1H-咪唑-4-基）乙基）-2-甲基苯基]甲醇皮肤疾病和状态的治疗
公开(公告)号：EP2616067B1
公开(公告)日：2016-05-18
申请号：EP11760961.0
申请日：2011-09-16
申请人： ALLERGAN, INC.
发明人： DIBAS, Mohammed I. , CHOW, Ken , DONELLO, John E. , GARST, Michael E. , GIL, Daniel W. , WANG, Liming
IPC分类号： A61K31/4174 , A61P17/04
CPC分类号： A61K31/4174 , A61K9/0014 , A61K31/4164 , C07D233/64 , Y10S514/912
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公开(公告)号：EP2964268A1
公开(公告)日：2016-01-13
申请号：EP14712952.2
申请日：2014-03-06
申请人： ALLERGAN, INC.
发明人： SINHA, Santosh C. , CHOW, Ken , WANG, Liming , BHAT, Smita S. , SWIFT, Brandon D. , ATTAR, Mayssa , GARST, Michael E.
CPC分类号： A61K47/48115 , A61K9/0048 , A61K47/481 , A61K47/48123 , A61K47/48246 , A61K47/55 , A61K47/554 , A61K47/64 , C07K7/645
摘要： The present invention describes antibiotic conjugates. These single drug entities are formed connecting one antibiotic with another antibiotic. Upon topical application to the eye, the conjugate hybrid would undergo enzymatic and/or hydrolytic cleavage to release the individual drugs.
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6.发明授权NOVEL 1,2- BIS-SULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS 有权NEW 1,2-双 - 磺酰胺为受体的趋化因子调节剂的
公开(公告)号：EP2651901B1
公开(公告)日：2015-05-27
申请号：EP11805321.4
申请日：2011-12-12
申请人： ALLERGAN, INC.
发明人： YUAN, Haiqing , BEARD, Richard L. , LIU, Xiaoxia , DONELLO, John E. , VISWANATH, Veena , GARST, Michael E.
IPC分类号： C07D231/18 , C07D307/82 , C07D333/34 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04 , C07C311/44 , A61K31/381 , A61K31/427 , A61K31/422
CPC分类号： A61K31/381 , A61K31/343 , A61K31/37 , A61K31/404 , A61K31/4155 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/429 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/497 , A61K31/498 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/55 , A61K31/635 , C07C311/21 , C07C311/44 , C07D231/18 , C07D307/82 , C07D333/34 , C07D405/12 , C07D407/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07D513/04
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7.发明公开N-(IMIDAZOLIDIN-2-YLIDENE)QUINOLINE DERIVATIVES AS MODULATORS OF ALPHA 2 ADRENERGIC RECEPTORS 审中-公开N-（咪唑烷-2-基） - 二氢化茚-2-磺酸盐调节剂VON ALPHA-2-ADRENERGISCHEN REZEPTOREN
公开(公告)号：EP2736902A1
公开(公告)日：2014-06-04
申请号：EP12740272.5
申请日：2012-07-20
申请人： Allergan, Inc.
IPC分类号： C07D403/12 , A61K31/435 , A61K31/4375 , A61K31/4985 , A61P17/00 , A61P35/00 , A61P29/00 , A61P25/00
CPC分类号： A61K31/4709 , A61K31/4375 , A61K31/4985 , C07D401/12 , C07D403/12 , C07D471/04
摘要： The present invention relates to novel N-(imidazolidin-2-ylidene)quino- line derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals. Formula (I).
摘要翻译： 本发明涉及新的N-（咪唑烷-2-亚基）喹啉衍生物，其制备方法，含有它们的药物组合物及其作为药物的用途。
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8.发明公开POLYCYCLIC PYRROLIDINE-2,5-DIONE DERIVATIVES AS -FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS 审中-公开多环吡啶-2,5-二氧杂环己烷甲醛脱氢酶-1（FPRL-1）-REZEPTORMODULATOREN
公开(公告)号：EP2731931A1
公开(公告)日：2014-05-21
申请号：EP12735412.4
申请日：2012-07-03
申请人： Allergan, Inc.
发明人： BEARD, Richard L. , VULIGONDA, Vidyasagar , VU, Thong , DONELLO, John E. , VISWANATH, Veena , GARST, Michael E.
IPC分类号： C07D209/96 , A61K31/4015 , A61P27/00 , A61P25/00 , A61P31/00 , A61P17/00 , A61P9/00 , A61P19/00 , C07D401/12
CPC分类号： C07D209/96 , C07D401/12
摘要： The present invention relates to novel polycyclic pyrrolidine-2, 5-dione derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators the N-formyl peptide receptor like-1 (FPRL-1) receptor.
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9.发明公开DIHYDRONAPHTHALENE AND NAPHTHALENE DERIVATIVES AS N-FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS 审中-公开二氢萘甲酸钠 - 萘磺酸盐N-甲基哌啶酮类似物-1（FPRL-1）-REZEPTORMODULATOREN
公开(公告)号：EP2686295A1
公开(公告)日：2014-01-22
申请号：EP12708478.8
申请日：2012-03-02
申请人： Allergan, Inc.
发明人： VULIGONDA, Vidyasagar , BEARD, Richard L. , VU, Thong , DONELLO, John E. , VISWANATH, Veena , GARST, Michael E.
IPC分类号： C07C233/59 , A61K31/16 , A61P29/00
CPC分类号： C07C235/84 , C07C233/59 , C07C235/82 , C07C2602/10
摘要： The present invention relates to novel dihydronaphthalene and naphthalene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of the N-formyl peptide receptor like-1 (FPRL-1) receptor.
摘要翻译： 本发明涉及新型二氢萘和萘衍生物，其制备方法，含有它们的药物组合物及其作为N-甲酰基肽受体1（FPRL-1）受体调节剂的药物的用途。
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10.发明公开DERIVATIVES OF CYCLOALKYL- AND CYCLOALKENYL-1,2-DICARBOXYLIC ACID COMPOUNDS HAVING FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) AGONIST OR ANTAGONIST ACTIVITY 审中-公开衍生的大肠杆菌 - 环丙基-1,2-DICARBONSÄUREVERBINDUNGENMIT FORMYLPEPTIDREZEPTOR-LIKE-1（FPRL-1）-AGONISTISCHER ODER ANTAGONISTISCHER WIRKUNG
公开(公告)号：EP2585054A1
公开(公告)日：2013-05-01
申请号：EP11729858.8
申请日：2011-06-23
申请人： Allergan, Inc.
IPC分类号： A61K31/167 , A61K31/192 , A61K31/216 , A61K31/44 , C07C233/45 , A61P27/02 , A61P27/06 , A61P29/00
CPC分类号： C07C323/40 , A61K31/16 , A61K31/167 , A61K31/192 , A61K31/195 , A61K31/215 , A61K31/216 , A61K31/4035 , A61K31/44 , C07C233/58 , C07C233/59 , C07C311/46 , C07C2603/94 , C07D213/75 , C07D493/08
摘要： The invention provides well defined compounds having FPRL-1 agonist or antagonist activity. As such, the compounds of the invention are useful for treating a variety of ocular disorders.
摘要翻译： 本发明提供具有FPRL-1激动剂或拮抗剂活性的明确定义的化合物。 因此，本发明的化合物可用于治疗各种眼部疾病。
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