公开(公告)号：EP1028947B1

公开(公告)日：2002-06-12

申请号：EP98956442.2

申请日：1998-11-05

申请人： SCHERING CORPORATION

发明人： ASLANIAN, Robert, G. ,  McCORMICK, Kevin, D. ,  MUTAHI, Mwangi, Wa

IPC分类号： C07D233/64 ,  A61K31/415

CPC分类号： C07D233/64 ,  A61K31/445 ,  A61K31/495 ,  A61K31/415 ,  A61K2300/00

摘要： Disclosed are novel phenyl-alkyl-imidazoles of formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein A and R, are as defined in the specification. Also disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines, comprising administering an effective amount of a compound of formula (I) (or a salt or solvate thereof) to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula (I) in combination or admixture with a histamine H1 receptor antagonist.

公开(公告)号：EP1028948A1

公开(公告)日：2000-08-23

申请号：EP98956444.8

申请日：1998-11-05

申请人： SCHERING CORPORATION

发明人： ASLANIAN, Robert, G. ,  McCORMICK, Kevin, D. ,  PIWINSKI, John, J.

IPC分类号： C07D233/64 ,  A61K31/415 ,  C07D409/12 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12

CPC分类号： C07D233/64 ,  A61K31/445 ,  A61K31/495 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  A61K31/415 ,  A61K2300/00

摘要： Disclosed are novel phenyl-alkyl-imidazoles of formula (I) wherein R1, R7, m, n, p, q, X, Y, Z, R and R15 are as defined in the specification. Also disclosed are pharmaceutical compositions comprising the compounds of formula (I). Further disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines by administering compounds of formula (I). Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula (I) in combination or admixture with a histamine H¿1? receptor antagonist.

公开(公告)号：EP1028947A1

公开(公告)日：2000-08-23

申请号：EP98956442.2

申请日：1998-11-05

申请人： SCHERING CORPORATION

发明人： ASLANIAN, Robert, G. ,  McCORMICK, Kevin, D. ,  MUTAHI, Mwangi, Wa

IPC分类号： C07D233/64 ,  A61K31/415

CPC分类号： C07D233/64 ,  A61K31/445 ,  A61K31/495 ,  A61K31/415 ,  A61K2300/00

摘要： Disclosed are novel phenyl-alkyl-imidazoles of formula (I) or pharmaceutically acceptable salts or solvates thereof, wherein A and R, are as defined in the specification. Also disclosed are methods of treating allergy, inflammation, hypotension, glaucoma, sleeping disorders, states of hyper and hypo motility of the gastrointestinal tract, hypo and hyperactivity of the central nervous system, Alzheimer's, schizophrenia, obesity and migraines, comprising administering an effective amount of a compound of formula (I) (or a salt or solvate thereof) to a patient in need of such treatment. Also disclosed are methods for treatment of upper airway allergic responses comprising administering a compound, or salt or solvate thereof, of formula (I) in combination or admixture with a histamine H1 receptor antagonist.

公开(公告)号：EP0729459A1

公开(公告)日：1996-09-04

申请号：EP95902442.0

申请日：1994-11-10

申请人： SCHERING CORPORATION

发明人： ASLANIAN, Robert, G. ,  GREEN, Michael, J. ,  SHIH, Neng-Yang

IPC分类号： C07D233 ,  A61K31 ,  A61P9 ,  A61P25 ,  A61P29 ,  A61P37 ,  A61P43 ,  C07D401

CPC分类号： C07D233/64 ,  C07D401/12

摘要： The invention provides novel phenyl-alkyl-imidazoles of formula (I) wherein A, R1, R2, m and n are as defined in the specification, and the group —(CH¿2?)n—A—R?1¿ is at the 3- or 4-position, together with their pharmaceutically acceptable salts. These phenyl-alkyl-imidazoles and salts have valuable pharmacological properties, especially CNS activities and activity against inflammatory disease.

公开(公告)号：EP2443121A2

公开(公告)日：2012-04-25

申请号：EP10782456.7

申请日：2010-06-15

申请人： Schering Corporation

发明人： ZHU, Zhaoning ,  HUANG, Xianhai ,  PALANI, Anandan ,  GREENLEE, William, J. ,  ASLANIAN, Robert, G.

IPC分类号： C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/551 ,  A61K31/553 ,  A61K31/554 ,  A61P25/28

CPC分类号： C07D498/04 ,  C07D471/04 ,  C07D513/04

摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the Formula (I): Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of Formula (I).

摘要翻译： 本发明提供了γ分泌酶调节剂的新化合物。 所述化合物具有式（I）：还公开了调节γ分泌酶活性的方法和使用式（I）化合物治疗阿尔茨海默氏病的方法。

公开(公告)号：EP2142538B1

公开(公告)日：2011-10-26

申请号：EP08714240.2

申请日：2008-02-11

申请人： Schering Corporation

发明人： ZHENG, Junying ,  MCCORMICK, Kevin, D. ,  CHAO, Jianhua ,  BOYCE, Christopher, W. ,  ASLANIAN, Robert, G. ,  YU, Younong

IPC分类号： C07D405/06 ,  C07D405/08 ,  C07D405/14 ,  C07D409/06 ,  C07D417/14 ,  C07D491/052 ,  A61K31/353 ,  A61P25/06

CPC分类号： C07D405/06 ,  C07D405/08 ,  C07D405/14 ,  C07D409/06 ,  C07D417/14 ,  C07D491/052

摘要： In its many embodiments, the present invention provides a novel class of chroman compounds of formula I as α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of prepaxing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

公开(公告)号：EP2227471A1

公开(公告)日：2010-09-15

申请号：EP08859260.5

申请日：2008-12-09

申请人： Schering Corporation

发明人： HUANG, Xianhai ,  PALANI, Anandan ,  ASLANIAN, Robert, G.

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/5025 ,  A61P25/28

CPC分类号： C07D487/04 ,  C07D471/04

摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula [Chemical formula should be inserted here as it appears on abstract in electronic form.] Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).

公开(公告)号：EP2205588A2

公开(公告)日：2010-07-14

申请号：EP08835011.1

申请日：2008-09-25

申请人： Schering Corporation

发明人： CHAO, Jianhua ,  ASLANIAN, Robert, G. ,  ZHENG, Junying

IPC分类号： C07D401/14 ,  C07D417/14 ,  A61K31/506 ,  A61K31/4523 ,  A61P1/00 ,  A61P25/00 ,  A61P3/04 ,  A61P3/10 ,  A61P37/08

CPC分类号： C07D417/14 ,  C07D401/14

摘要： The present invention relates to novel Oxypiperidine Derivatives, pharmaceutical compositions comprising the Oxypiperidine Derivatives and the use of the Oxypiperidine Derivatives for treating or preventing treating allergy, an allergy-induced airway response, congestion, hypotension, a cardiovascular disease, a gastrointestinal disorder, obesity, a sleep disorder, pain, diabetes, a diabetic complication, impaired glucose tolerance, impaired fasting glucose or a central nervous system (CNS) disorder.

公开(公告)号：EP2200990A1

公开(公告)日：2010-06-30

申请号：EP08829478.0

申请日：2008-09-04

申请人： Schering Corporation

发明人： ASLANIAN, Robert, G. ,  HUANG, Xianhai ,  PALANI, Anandan ,  QIN, Jun ,  ZHOU, Wei ,  ZHU, Xiaohong ,  MAZZOLA, Robert, D., Jr. ,  DHONDI, Pawan ,  GREENLEE, William, J.

IPC分类号： C07D237/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

CPC分类号： C07D403/12 ,  C07D237/14 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D409/14 ,  C07D417/14

摘要： This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's Disease using the compounds of formula (I).

摘要翻译： 本发明提供了γ分泌酶调节剂的新化合物。 该化合物具有式（I）。 还公开了使用式（I）化合物调节γ分泌酶活性的方法和治疗阿尔茨海默病的方法。

公开(公告)号：EP2125784A2

公开(公告)日：2009-12-02

申请号：EP08714239.4

申请日：2008-02-11

申请人： Schering Corporation ,  Pharmacopeia, LLC

发明人： MCCORMICK, Kevin, D. ,  BOYCE, Christopher, W. ,  SHIH, Neng-yang ,  ASLANIAN, Robert, G. ,  CHAO, Jianhua ,  FEVRIER, Salem ,  MANGIARACINA, Pietro ,  YU, Younong ,  HUANG, Chia-yu ,  LIANG, Bo ,  LU, Huagang ,  LIU, Rong-qiang

IPC分类号： C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/403 ,  A61P31/10 ,  A61P29/00 ,  A61P9/00 ,  A61P25/22

CPC分类号： C07D403/02 ,  C07D401/14 ,  C07D403/06 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14

摘要： In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more conditions associated with the α2C adrenergic receptors using such compounds or pharmaceutical compositions.

摘要翻译： 在其许多实施方案中，本发明提供了一类新的作为α2C肾上腺素能受体激动剂抑制剂的吲哚啉，制备此类化合物的方法，含有一种或多种这类化合物的药物组合物，制备包含一种或多种这类化合物的药物制剂的方法， 使用这样的化合物或药物组合物治疗，预防，抑制或改善与α2C肾上腺素能受体相关的一种或多种病症的方法。