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    Novel compound useful for the treatment of degenerative and inflammatory diseases
    62.
    发明公开
    Novel compound useful for the treatment of degenerative and inflammatory diseases 有权
    Neuartige Verbindung zur Behandlung von Degenerations- undEntzündungskrankheiten

    公开(公告)号：EP2792677A1

    公开(公告)日：2014-10-22

    申请号：EP14175887.0

    申请日：2010-06-25

    申请人： Galapagos N.V.

    发明人： Blanc, Javier ,  Menet, Christel Jeanne Marie

    IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00 ,  A61P35/00 ,  A61P37/00

    CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K45/06

    摘要： A compound is disclosed that has a formula represented by the following:

    This compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of IL6.

    摘要翻译： 公开了具有下列化学式的化合物：该化合物可以制备为药物组合物，并且可以用于预防和治疗哺乳动物包括人的各种病症，包括作为非限制性实例 ，炎性病症，自身免疫性疾病，增殖性疾病，移植排斥反应，涉及软骨周转损伤的疾病，先天性软骨畸形和/或与IL6分泌过多相关的疾病。

    NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES
    64.
    发明公开
    NOVEL COMPOUND USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES 有权
    新型复方用于治疗退行性和炎性疾病

    公开(公告)号：EP2702058A1

    公开(公告)日：2014-03-05

    申请号：EP12717288.0

    申请日：2012-04-26

    申请人： Galapagos N.V.

    发明人： MENET, Christel, Jeanne, Marie ,  HODGES, Alastair, James ,  VATER, Huw, David

    IPC分类号： C07D471/04 ,  A61K31/4162 ,  A61P19/02

    CPC分类号： A61K31/496 ,  A61K31/437 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  C07D471/04 ,  C07D491/107

    摘要： A pyrazolopyridine compound according to Formula I, able to inhibit JAK is disclosed,as well as pharmaceutically acceptable salts, a solvate thereof, solvates of the pharmaceutically acceptable salts and biologically active metabolite thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment or prophylaxis of a variety of conditions in mammals including humans, and particularly, such conditions as may be associated with aberrant JAK activity, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hyper secretion of IL6.

    摘要翻译： 公开了能够抑制JAK的根据式I的吡唑并吡啶化合物及其药学上可接受的盐，溶剂化物，其药学上可接受的盐和其生物活性代谢物的溶剂化物。 该化合物可以制备成药物组合物，并且可以用于治疗或预防包括人在内的哺乳动物的多种病症，特别是可能与异常JAK活性相关的病症，包括非限制性的 例如，过敏症，炎性病症，自身免疫性疾病，增殖性疾病，移植排斥，涉及软骨更新损伤的疾病，先天性软骨畸形和/或与IL6高度分泌相关的疾病。