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61.发明公开
公开(公告)号：EP1558737A4
公开(公告)日：2008-06-11
申请号：EP03751572
申请日：2003-10-16
申请人： LG LIFE SCIENCES LTD
发明人： LEE SOOJIN , KOH SANG SEOK , LEE BOGMAN , CHUNG HYUN-HO , CHOO SEUNG-HO , YANG DOO SEOK
CPC分类号： C07K14/4748 , A61K38/00 , C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The invention relates generally to the changes in gene expression in human tissues from cancer patients. The invention relates specifically to human gene families which are differentially expressed in cancer tissues of breast, colon, esophagus, kidney, liver, lung, lymph node, ovary, pancreas, prostate, rectum, and/or stomach compared to corresponding normal tissues.
摘要翻译： 本发明一般涉及来自癌症患者的人体组织中基因表达的变化。 本发明具体涉及与相应的正常组织相比在乳腺，结肠，食管，肾，肝，肺，淋巴结，卵巢，胰腺，前列腺，直肠和/或胃的癌组织中差异表达的人基因家族。
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62.发明公开PROCESS FOR PREPARING 7-CHLORO-1-CYCLOPROPYL-6-FLUORO-4-OXO-1,4-DIHYDRO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID 有权PROCESS FOR 7-氯-1-环丙基-6-氟-4-氧代-1,4-二氢-1,8-二氮杂萘-3-羧酸的的制备酸
公开(公告)号：EP1678174A4
公开(公告)日：2008-02-27
申请号：EP04793563
申请日：2004-10-22
申请人： LG LIFE SCIENCES LTD
发明人： SHIN HYUN-IK , CHANG JAY-HYOK , LEE KYU-WOONG
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Starting from ethyl 3-(2,6-dichloro-5-fluoropyridin-3-yl)-3-oxo-propanoate (1), the present invention provides highly pure 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid (5) inone-potfour stepsusing a single solvent.
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公开(公告)号：EP1478649A4
公开(公告)日：2006-09-13
申请号：EP02705514
申请日：2002-02-28
申请人： LG LIFE SCIENCES LTD
发明人： LEE CHANG-SEOK , KIM GEUN-TAE , JANG YONG-JIN , RYU EUN-JUNG , CHO YANG-RAE , JOO HYUNG-YEUL , SHIN JEONG-EUN , LEE SUN-HWA , KOO KI-DONG
IPC分类号： C07D501/24 , C07D501/36 , A61K31/546 , A61P31/04 , C07D501/00
CPC分类号： C07D501/00
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64.发明公开(+)-TRANS-ISOMERS OF (1-PHOSPHONOMETHOXY-2-ALKYLCYCLOPROPYL) METHYL NUCLEOSIDE DERIVATIVES, PROCESS FOR THE PREPARATION OF STEREOISOMERS THEREOF, AND USE OF ANTIVIRAL AGENTS THEREOF 审中-公开（+） - （1-膦酰-2-烷基环）METHYLNUKLEOSIDDERIVATEN，PROCESS FOR PRODUCING立体异构体的反式异构体，以及由此衍生抗病毒剂USE
公开(公告)号：EP1546164A4
公开(公告)日：2006-06-07
申请号：EP03798577
申请日：2003-09-22
申请人： LG LIFE SCIENCES LTD
发明人： CHOI JONG-RYOO , HWANG JAE-TAEG , CHO DONG-GYU , ROH KEE-YOON , KIM CHUN-HYUNG , KIM CHUNG-MI , HAN MIN-JOON , KIM JEONG-MIN , CHO WOO-YOUNG , KIM GYOUNG-WON , AHN SINBYOUNG
IPC分类号： C07F9/40 , C07F9/6512 , C07F9/6561 , A61K31/675 , C07F9/6509
CPC分类号： C07F9/65616 , C07F9/4006 , C07F9/65121
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65.发明公开METHOD FOR PREPARING A (R)- OR (S)- FORM OF N-(2,6-DIMETHYL PHENYL) ALANINE AND A COUNTER ENANTIOMERIC FORM OF N-(2,6-DIMETHYL PHENYL) ALANINE ESTER THERETO USING ENZYME 审中-公开- 形式的N-（2,6-二甲基苯基）丙氨酸，以及使用对映体酶AGAINST N-（2,6-二甲基苯基）丙氨酸酯的一种形式或（S） - 方法呈现的（R）的
公开(公告)号：EP1587943A1
公开(公告)日：2005-10-26
申请号：EP03813309.6
申请日：2003-12-05
发明人： PARK, oh-jin , LEE, Sang Who , PARK, tae-yoon , LEE, Sang Hyun , JOUNG, Won-Kyo , SUH, Byoung-Woo , CHOI, Jeung-soon , JOE, Goonho , CHEONG, Jae Ho
IPC分类号： C12P41/00 , C07C239/08
CPC分类号： C12P41/005 , C12P13/06
摘要： The present invention provides methods for stereospecifically preparing (R)- or (S)-N-(2,6-dimethyl phenyl) alanine and counter ester compounds thereto using enzyme, which comprises reacting an enzyme having hydrolytic activity specific to one enantiomer of racemic (R), (S)-N-(2,6-dimethyl phenyl) alanine esters ((R)-enantiomer and (S)-enantiomer) with the racemic mixture above to obtain (R)- or (S)-N-(2,6-dimethyl phenyl) alanine by optical resolution, or extracting (S)- or (R)-N-(2,6-dimethyl phenyl) alanine ester as an unreacted compound from a reaction mixture using solvent, or esterifying a certain alanine enantiomer separated by the optical resolution with alcohol to synthesize (S)- or (R)-N-(2,6-dimethyl phenyl) alanine ester.
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66.发明公开NEW CRYSTALLINE FORMS OF (2S)-N-5-(AMINO(IMINO)METHYL)-2-THIENYLMETHYL-1-(2R)-2-((CARBOXYMETHYL)AMINO)-3,3-DIPHENYLPROPANOYL-2-PYRROLIDINECARBOXAMIDE.nH2O 审中-公开（2S）-N-5-（氨基（亚氨基）甲基）-2-噻吩甲基-1-（2R）-2 - （（羧甲基）氨基）-3,3-二苯基丙酰基-2-吡咯烷基碳酰胺氨基甲酸酯
公开(公告)号：EP1487826A4
公开(公告)日：2005-06-29
申请号：EP03744723
申请日：2003-03-21
申请人： LG LIFE SCIENCES LTD
发明人： KIM AERI , PARK JAE-HYEON , YOON SUK-KYOON , KIM BONG-CHAN , KIM SUNG-JI , CHO KWAN-HYUNG
CPC分类号： C07D409/12 , C07K5/06078 , C07K2299/00
摘要： The present invention relates to crystalline forms of (2S)-N-5-[amino(imino)methyl]-2-thienylmethyl-1-(2R)-2-[(carboxymethyl)amino]-3,3-diphenylpropanoyl-2-pyrrolidinecarboxamide nH2O.
摘要翻译： 本发明涉及（2S）-N-5- [氨基（亚氨基）甲基] -2-噻吩基甲基-1-（2R）-2 - [（羧甲基）氨基] -3,3-二苯基丙酰基-2 - 吡咯烷甲酰胺nH 2 O.
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67.发明公开METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST PATHOGENIC HELICOBACTER BACTERIA 审中-公开VERFAHREN ZUR VERWENDUNG VON FLUORCHINOLON-VERBINDUNGEN GEGEN PATHOGENE HELICOBACTER-BAKTERIEN
公开(公告)号：EP1337252A4
公开(公告)日：2005-06-22
申请号：EP01985001
申请日：2001-11-08
申请人： LG LIFE SCIENCES LTD
IPC分类号： C07D471/04 , A61K31/4375 , A61K31/47 , A61P1/04 , A61P31/04
CPC分类号： A61K31/4375
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公开(公告)号：EP1367996A4
公开(公告)日：2005-04-13
申请号：EP02712488
申请日：2002-02-04
申请人： LG LIFE SCIENCES LTD
发明人： KIM YONG-SIK , RYOO JE-PHIL , CHOI MI-SUK
IPC分类号： A61K9/10 , A61K9/22 , A61K31/546 , A61K47/14 , A61K47/22
CPC分类号： A61K47/14 , A61K9/0019 , A61K9/10 , A61K31/546 , A61K47/22
摘要： Disclosed is a sustained-release suspension composition containing ceftiofur hydrochloride, tocopherol or a derivative thereof, and a biocompatible oil.
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69.发明公开A METHOD OF TREATING BACTERIAL INFECTIONS USING GEMIFLOXACIN OR A SALT THEREOF AND A CARBAPENEM ANTIBACTERIAL AGENT 有权方法细菌感染与吉米沙星治疗或ONE及其盐类和碳青霉烯类抗菌介质
公开(公告)号：EP1458390A1
公开(公告)日：2004-09-22
申请号：EP02795443.7
申请日：2002-11-29
发明人： NICONOVICH, Nancy , RITTENHOUSE, Stephen , McCLOSKEY, Lynn , PAEK, Kyong-SookR & D Park, LG Life Sciences Ltd. , KIM, Mu-YongR & D Park, LG Life Sciences, Ltd.
IPC分类号： A61K31/47
CPC分类号： A61K31/4375 , A61K31/407 , A61K2300/00
摘要： The present invention relates to a method of treating anti-bacterial infections which method comprises the separate, simultaneous or sequential administration to a patient in need thereof, of an effective amount of gemifloxacin or a salt thereof and a carbapenem antibacterial.
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70.发明授权
公开(公告)号：EP1214321B1
公开(公告)日：2004-07-14
申请号：EP00958776.7
申请日：2000-09-01
发明人： CHO, Sungwook, LG Chem Investment, Ltd. , CHOI, Hoon, LG Chem Investment Ltd. , HAYLER, John, David GlaxoSmithKline
IPC分类号： C07D471/04 , C07D207/22 , C07B43/04
CPC分类号： C07D471/04
摘要： A process for the production of Naphthyridine-3-carboxylic acid derivatives of formula (I) having antibacterial activity.
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