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    METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING
    62.
    发明公开
    METHODS AND DEVICES FOR ORTHOVOLTAGE OCULAR RADIOTHERAPY AND TREATMENT PLANNING 审中-公开
    方法和设备目镜ORTHO电压放射治疗和治疗计划

    公开(公告)号：EP2231276A4

    公开(公告)日：2011-04-06

    申请号：EP08859241

    申请日：2008-10-31

    申请人： ORAYA THERAPEUTICS INC

    发明人： GERTNER MICHAEL ,  ARNOLDUSSEN MARK ,  CHELL ERIK ,  HANSEN STEVEN D ,  LIANG JUNZHONG

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1037 ,  A61N5/1017 ,  A61N5/103 ,  A61N5/1064 ,  A61N2005/1091

    摘要： A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.

    METHODS FOR IMPLEMENTING MICROBEAM RADIATION THERAPY
    67.
    发明公开
    METHODS FOR IMPLEMENTING MICROBEAM RADIATION THERAPY 审中-公开
    程序为微束放疗的实现

    公开(公告)号：EP1885451A2

    公开(公告)日：2008-02-13

    申请号：EP06720604.5

    申请日：2006-02-10

    申请人： Brookhaven Science Associates

    发明人： DILMANIAN, Avraham, F. ,  MORRIS, Gerard, M. ,  HAINFELD, James, F.

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1042 ,  A61N5/1017 ,  A61N5/1084 ,  A61N2005/1091 ,  A61N2005/1098

    摘要： A method of performing microbeam radiation therapy (MRT) includes delivering a dose only to selected tissue in a target volume (10) with continuous broad beam, first, by interleaving arrays of microplanar beams (30,36) only at the target (10). Administered contrast agents can supplement the effect by preferentially increasing the target dose relative to dose in normal tissue. A broad beam effect is alternatively created using non-interleaving microbeam array(s) with scattering agents administered to selected tissue that preferentially increase valley dose (69) within target to approximate broad beam. The methods of interleaving microbeams are also applied to treat diseases and conditions by ablating at least a portion of selected tissue, or by damaging blood-brain barrier for efficient drug and/or cell administration. A system for performing interlaced microbeam radiosurgery preferably includes two orthogonal radiation source arms (102) for producing and interleaving microbeam arrays (30,36) at the target volume (10). The methods treat tumors, pain, epilepsy, and neurological diseases.

    TREATMENT OF AGE-RELATED MACULAR DEGENERATION
    69.
    发明公开
    TREATMENT OF AGE-RELATED MACULAR DEGENERATION 有权
    治疗年龄相关性黄斑变性

    公开(公告)号：EP1660181A2

    公开(公告)日：2006-05-31

    申请号：EP04779182.7

    申请日：2004-07-26

    申请人： Xoft Microtube, Inc.

    发明人： FORMAN, Michael ,  LOVOI, Paul, A. ,  SMITH, Peter, C.

    IPC分类号： A61N5/00

    CPC分类号： A61N5/1001 ,  A61B2090/306 ,  A61F9/0079 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/1017 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/1022 ,  A61N2005/1098

    摘要： Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube (20) inserted via a catheter(12) around the globe of the eye, to a position behind the macula (16). Methods are described for properly locating the catheter (12) and x-ray tube (20), using illumination on the catheter (12) and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube (12) from the target tissue, and for achieving prescription radiation dose in the choroid (22) while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.