公开(公告)号：EP1660181B1

公开(公告)日：2009-07-08

申请号：EP04779182.7

申请日：2004-07-26

申请人： Xoft Microtube, Inc.

发明人： FORMAN, Michael ,  LOVOI, Paul, A. ,  SMITH, Peter, C.

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1001 ,  A61B2090/306 ,  A61F9/0079 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/1017 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/1022 ,  A61N2005/1098

摘要： Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube (20) inserted via a catheter(12) around the globe of the eye, to a position behind the macula (16). Methods are described for properly locating the catheter (12) and x-ray tube (20), using illumination on the catheter (12) and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube (12) from the target tissue, and for achieving prescription radiation dose in the choroid (22) while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.

公开(公告)号：EP1738390A2

公开(公告)日：2007-01-03

申请号：EP05713513.9

申请日：2005-02-10

申请人： Xoft Microtube, Inc.

发明人： LOVOI, Paul, A. ,  RIEKE, John ,  LIM, Alex ,  SMITH, Peter, C. ,  RUSCH, Thomas, W.

IPC分类号： H01J35/10

CPC分类号： A61N5/1002 ,  A61M25/003 ,  A61M25/10 ,  A61M2025/0004 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/0039 ,  A61N2005/005 ,  A61N2005/1022 ,  H01J35/32 ,  H01J2235/1216 ,  H01J2235/122 ,  H01J2235/1262 ,  H05G1/025

摘要： A miniature X-ray tube is cooled using a catheter (12) preferably having multiple small lumens for inflow and outflow of coolant. Inflow maybe through an outer lumen(s) in a concentric-extrusion catheter, the liquid turning back at the distal end (14) of the catheter to a proximal flow over the anode end of the X-ray tube and through an inner lumen within which the X-ray tube is positioned. A coolant distribution head may engage with the anode end of the X-ray tube, with small orifices so as to distribute coolant essentially evenly over the anode surface. Temperature and flow rate of the inflowing coolant liquid are balanced so as to optimize heat transfer while efficiently carrying coolant through small lumens without the need for high pressures. Some embodiments use the inflation liquid in an applicator balloon as the coolant, with the liquid actively flowing or in a simplified system with liquid static.

公开(公告)号：EP1599883A2

公开(公告)日：2005-11-30

申请号：EP04713782.3

申请日：2004-02-23

申请人： Xoft Microtube, Inc.

发明人： RUSCH, Thomas, W. ,  SMITH, Peter, C. ,  HANSEN, Steven, D. ,  LOVOI, Paul, A. ,  PELLINEN, Donald, G.

IPC分类号： G21G4/00

CPC分类号： H01J35/08 ,  H01J35/32 ,  H01J2235/081 ,  H01J2235/087 ,  H01J2235/164

摘要： A miniature x-ray tube has an anode assembly capable of transmitting x-rays through the anode and over a wide angular range. The anode (62) is in the shape of a cone or truncated cone with an axis on the x-ray tube frame axis, formed of low Z material with high thermal conductivity for heat dissipation. A target material on the anode body is in a thin layer (20), which may be approximately 0.5 to 5 microns thick. In one embodiment a tube evacuation exhaust port (64) at the tail end of the anode assembly forms a cavity for a getter (56), with a pinched-off tubulation (48) at the end of the cavity.

公开(公告)号：EP1738390B1

公开(公告)日：2011-09-14

申请号：EP05713513.9

申请日：2005-02-10

申请人： Xoft Microtube, Inc.

发明人： LOVOI, Paul, A. ,  RIEKE, John ,  LIM, Alex ,  SMITH, Peter, C. ,  RUSCH, Thomas, W.

IPC分类号： H01J35/00 ,  H01J35/32 ,  H01J35/12 ,  A61N5/02 ,  A61B6/00 ,  A61M25/00

CPC分类号： A61N5/1002 ,  A61M25/003 ,  A61M25/10 ,  A61M2025/0004 ,  A61M2025/0034 ,  A61M2025/0036 ,  A61M2025/0039 ,  A61N2005/005 ,  A61N2005/1022 ,  H01J35/32 ,  H01J2235/1216 ,  H01J2235/122 ,  H01J2235/1262 ,  H05G1/025

摘要： A miniature X-ray tube is cooled using a catheter (12) preferably having multiple small lumens for inflow and outflow of coolant. Inflow maybe through an outer lumen(s) in a concentric-extrusion catheter, the liquid turning back at the distal end (14) of the catheter to a proximal flow over the anode end of the X-ray tube and through an inner lumen within which the X-ray tube is positioned. A coolant distribution head may engage with the anode end of the X-ray tube, with small orifices so as to distribute coolant essentially evenly over the anode surface. Temperature and flow rate of the inflowing coolant liquid are balanced so as to optimize heat transfer while efficiently carrying coolant through small lumens without the need for high pressures. Some embodiments use the inflation liquid in an applicator balloon as the coolant, with the liquid actively flowing or in a simplified system with liquid static.

公开(公告)号：EP1660181A2

公开(公告)日：2006-05-31

申请号：EP04779182.7

申请日：2004-07-26

申请人： Xoft Microtube, Inc.

发明人： FORMAN, Michael ,  LOVOI, Paul, A. ,  SMITH, Peter, C.

IPC分类号： A61N5/00

CPC分类号： A61N5/1001 ,  A61B2090/306 ,  A61F9/0079 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/1017 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/1022 ,  A61N2005/1098

摘要： Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube (20) inserted via a catheter(12) around the globe of the eye, to a position behind the macula (16). Methods are described for properly locating the catheter (12) and x-ray tube (20), using illumination on the catheter (12) and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube (12) from the target tissue, and for achieving prescription radiation dose in the choroid (22) while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.