公开(公告)号：EP1660181B1

公开(公告)日：2009-07-08

申请号：EP04779182.7

申请日：2004-07-26

申请人： Xoft Microtube, Inc.

发明人： FORMAN, Michael ,  LOVOI, Paul, A. ,  SMITH, Peter, C.

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1001 ,  A61B2090/306 ,  A61F9/0079 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/1017 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/1022 ,  A61N2005/1098

摘要： Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube (20) inserted via a catheter(12) around the globe of the eye, to a position behind the macula (16). Methods are described for properly locating the catheter (12) and x-ray tube (20), using illumination on the catheter (12) and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube (12) from the target tissue, and for achieving prescription radiation dose in the choroid (22) while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.

公开(公告)号：EP1660181A2

公开(公告)日：2006-05-31

申请号：EP04779182.7

申请日：2004-07-26

申请人： Xoft Microtube, Inc.

发明人： FORMAN, Michael ,  LOVOI, Paul, A. ,  SMITH, Peter, C.

IPC分类号： A61N5/00

CPC分类号： A61N5/1001 ,  A61B2090/306 ,  A61F9/0079 ,  A61N5/0601 ,  A61N5/062 ,  A61N5/1017 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/1022 ,  A61N2005/1098

摘要： Age-related macular degeneration is treated by radiation delivered from a miniature x-ray tube (20) inserted via a catheter(12) around the globe of the eye, to a position behind the macula (16). Methods are described for properly locating the catheter (12) and x-ray tube (20), using illumination on the catheter (12) and viewing through the front of the eye, or sensors on the catheter and a scanned beam shone from the front of the eye. Fluorescent excited by x-rays can also be used. Also described are methods and devices for immobilizing the probe once properly located in the eye, for standoff of the x-ray tube (12) from the target tissue, and for achieving prescription radiation dose in the choroid (22) while eliminating dose to adjacent tissues. The x-ray treatment can be enhanced using a radiosensitizing drug, and can be combined with PDT.