公开(公告)号：EP1183559A1

公开(公告)日：2002-03-06

申请号：EP00918216.3

申请日：2000-03-22

Applicant: THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE NAVY

Inventor： FELDSTEIN, Mark, J. ,  GOLDEN, Joel, P. ,  LIGLER, Frances, S. ,  ROWE, Chris, A.

IPC: G02B6/00

CPC classification number: G01N21/648 ,  G01N21/552 ,  G01N21/7703 ,  G01N33/54373 ,  G01N33/54393 ,  G01N2021/7709 ,  G01N2021/7776 ,  G01N2021/7786 ,  G01N2021/7793 ,  G01N2201/024 ,  G02B6/10 ,  G02B6/4206

Abstract: A multimode waveguide device for assays includes a multimode waveguide with a patterned, reflective surface coating. The exposed portion or portions of the reflectively coated waveguide surface are for analyte recognition. A fluidics cell is attached to the waveguide so that the channel or channels of the fluidics cell match with the exposed portion or portions of the waveguide surface. The channel or channels direct one or more sample fluids over the exposed portion or portions of the waveguide surface. The reflective coating minimizes loss and scattering of excitation and fluorescence light during a fluorescence assay.

公开(公告)号：EP1004056A4

公开(公告)日：2001-08-16

申请号：EP98939349

申请日：1998-08-11

Applicant: BIO RAD LABORATORIES

Inventor： HEFFELFINGER DAVID M ,  BATTERSON REBECCA ANN ,  SALGADO RENATO

IPC: G01N21/64 ,  C12M1/00 ,  C12M1/34 ,  C12N15/09 ,  C12Q1/68 ,  G01N21/75 ,  G01N21/78 ,  G01N33/53 ,  G01N37/00 ,  G03B42/00 ,  G01N15/14 ,  G01N21/25 ,  G01N21/59 ,  G01N21/86 ,  G01N27/447

CPC classification number: G03B42/00 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/024

Abstract: An apparatus capable of measuring quantities of biological or other types of samples that have been labeled using any of a variety of techniques including fluorescence, radioisotopes, enzyme activated light emitting chemicals and enzyme activated fluorescent materials is provided. The provided scanner includes a source module (113) that preferably contains an internal laser emitting two different wavelengths of approximately the same intensity. An optional external light source may be coupled to the source module, thus adding further flexibility through the addition of other wavelengths (e.g. UV, visible, mid-IR, and IR). The scanner also includes a detection module. Within the detection module (115) are two detectors, thus allowing the simultaneous detection of multiple wavelengths. A bifurcated optical cable (111) is used to transfer the excitation and/or readout light from the source module to the sample and subsequently transfer the emitted and/or scattered light from the sample to the detection module.

公开(公告)号：EP1121581A1

公开(公告)日：2001-08-08

申请号：EP99947384.6

申请日：1999-09-18

Applicant: Carl Zeiss

Inventor： VÖLCKER, Martin ,  FATTINGER, Christof

IPC: G01N21/25 ,  G02B3/00 ,  G02B5/04

CPC classification number: G01N21/6452 ,  G01N21/253 ,  G01N2201/024 ,  G02B3/005 ,  G02B3/0068 ,  G02B5/045

Abstract: The invention relates to an imaging system for optical automatic analysers, especially fluorescence readers. On the sample side, the imaging system contains a cylindrical lens array (6) and a prism array (7), which is arranged upstream of the cylindrical lens array. The prismatic effect of the prisms (7a-7c) of the prism array (7) lies in the direction of the cylinder axes of the cylindrical lenses (6a-6c). Together with a telescopic imaging system (8, 11), the inventive imaging system creates a number of parallel cylindrical focussing volumes between the cylindrical lens array (6) and a detector array (10), these focussing volumes being slanted towards the optical axis of the telescopic system in relation to the vertical. The arrangement enables the detection of fluorescence with a large aperture in one direction, and at the same time enables depth selective analysis of the fluorescence signal, especially the discrimination of the fluorescent radiation originating from the areas around the bases of the sample containers from the fluorescent radiation originating from the solution above. With the focussing volumes that are slanted towards the bases of the sample containers, the imaging system ensures that the fluorescence from the areas around the bases of the sample containers (5a-5c) is detected with the same sensitivity even when the heights of the bases vary in the individual sample containers.

公开(公告)号：EP0608309A1

公开(公告)日：1994-08-03

申请号：EP92921559.0

申请日：1992-10-14

Applicant: IEI PTY Ltd.

Inventor： COLE, Martin, Terence

IPC: G01N21 ,  G08B17

CPC classification number: G01N21/274 ,  G01N21/4785 ,  G01N21/53 ,  G01N2201/024 ,  G01N2201/0636 ,  G01N2201/0642 ,  G01N2201/0696 ,  G08B17/107 ,  G08B17/113

Abstract: Un détecteur de pollution et de fumée comporte une chambre d'échantillonnage constituée de deux parties en matière plastique moulées. Cette chambre est dotée de deux séries de joints articulés comprenant des écrans (60, 63) qui viennent se superposer pour fomrer une série d'iris disposés au long de la chambre. L'appareil comporte en ses extrémités un récepteur (40) et un absorbeur (20) de lumière séparés par une zone d'échantillonnage d'air où l'on émet un éclair grâce à un module d'émission lumineuse (30) doté d'un nouveau réflecteur (32). Cet ensemble, facile à monter et démonter pour la maintenance, permet également un fonctionnement efficace.

公开(公告)号：EP0536283A4

公开(公告)日：1993-05-26

申请号：EP91912781

申请日：1991-06-13

Applicant: FIBERCHEM, INC.

Inventor： KLAINER, STANLEY, M. ,  THOMAS, JOHNNY, R. ,  BUTLER, MARCUS, S.

IPC: C12M1/34 ,  G01N21/01 ,  G01N21/03 ,  G01N21/25 ,  G01N21/75 ,  G01N21/77 ,  G01N21/80 ,  G01N33/543 ,  G01N21/57 ,  C12M1/16 ,  C12M1/18 ,  G01N31/22

CPC classification number: G01N21/75 ,  G01N21/253 ,  G01N21/77 ,  G01N21/80 ,  G01N2021/0193 ,  G01N2021/0325 ,  G01N2021/0385 ,  G01N2021/1738 ,  G01N2201/024 ,  G01N2201/0415

Abstract: Single or multi-cell reservoir sensors with single illumination sources and one or more detectors per cell unit have an arrangement whereby a gaseous, vapor or liquid sample enters the cell body and interacts with a sensing solution to detect and quantify a given species. Entrance of the sample into the sensor is through an opening in the cell body which may be covered with a membrane to contain the sensing reagent and to presort the species entering the cell. Reservoir cells can be used with organic, inorganic or biochemical sensing materials. A reservoir chemical sensor has a sensor body containing a reservoir cell channel around which source and detector are positioned within the cell body. A replaceable modular reservoir cell which contains sensing solution fits snugly and removably in the channel in the sensor body. Different reservoir cells can be easily inserted and removed from the sensor body. A variety of sensors such as alcohol, drugs of abuse, organic halides, cyanide and inorganic ions are provided.

公开(公告)号：EP0500879A1

公开(公告)日：1992-09-02

申请号：EP91916115.0

申请日：1991-09-04

Applicant: SEQUEL IMAGING, INC.

Inventor： LUTZ, Carl, David ,  LIANZA, Thomas, A.

IPC: G01J3

CPC classification number: G01J3/02 ,  G01J3/0272 ,  G01J3/0291 ,  G01J3/50 ,  G01J3/513 ,  G01N2021/174 ,  G01N2201/024

Abstract: Un colorimètre utilisé pour mesurer de la lumière transmise, réfléchie, émise et incidente comprend un support monté amovible sur une base et contenant un détecteur sensible aux couleurs ainsi qu'une partie électronique de traitement associé. Le détecteur s'adapte à une des têtes détachables que l'on peut sélectionner afin d'établir des conditions de mesure précises pour les diverses mesures à effectuer. Le colorimètre permet un étalonnage commun et cohérent de tous les éléments de l'industrie de la presse préliminaire, depuis le contrôle d'épreuves en couleur ou de transparences en couleur à l'étalonnage de moniteurs couleur vidéo.

公开(公告)号：EP3410097A1

公开(公告)日：2018-12-05

申请号：EP18180564.9

申请日：2013-10-08

Applicant: Vuv Analytics, Inc.

Inventor： HARRISON, Dale, A ,  HAYES, Anthony, T ,  WALSH, Philip

IPC: G01N21/33 ,  G01N21/05 ,  G01N21/15 ,  G01N30/74 ,  G01N33/00 ,  G01N21/85 ,  G01N21/03

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2021/8578 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system (100) is provided for detecting the presence of trace concentrations of gaseous species. In particular, a method of obtaining data regarding a gas analyte, comprising: providing the analyte from a gas chromatography column (130); providing the analyte to a gas flow cell (104); passing VUV wavelengths or less of light from a VUV source (110) through the gas flow cell (104); detecting absorption of the VUV wavelengths or less of light by the analyte through the use of a spectrometer (106, 154, 156) optically coupled to an optical output (142) of the gas flow cell (104); obtaining a three dimensional data set indicative of an amount of absorption of the analyte as a function of wavelength and time; and analyzing the three dimensional data set to determine an identity and quantity of the analyte.

公开(公告)号：EP2470888B1

公开(公告)日：2018-10-10

申请号：EP10711902.6

申请日：2010-03-31

Applicant: Hach Lange GmbH

Inventor： FARJAM, Aria ,  UTHEMANN, Rolf ,  BERGGOLD, Kai ,  LUNDGREEN, Ulrich ,  DE HEIJ, Bas

IPC: G01N21/11 ,  G01N21/85 ,  B01L3/00 ,  F04B43/08 ,  F04B43/12 ,  G01N35/10 ,  G01N21/03 ,  G01N21/05 ,  G01N21/78 ,  G01N21/84 ,  G01N33/18 ,  G01N1/40

CPC classification number: G01N21/8507 ,  B01L3/502715 ,  B01L3/50273 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2400/0481 ,  F04B43/082 ,  F04B43/12 ,  G01N21/05 ,  G01N21/11 ,  G01N21/78 ,  G01N33/18 ,  G01N35/1095 ,  G01N2001/4016 ,  G01N2021/0321 ,  G01N2021/0325 ,  G01N2021/0346 ,  G01N2021/054 ,  G01N2021/8411 ,  G01N2201/0218 ,  G01N2201/024

公开(公告)号：EP3171155A1

公开(公告)日：2017-05-24

申请号：EP16204878.9

申请日：2005-05-06

Applicant: Clondiag GmbH

Inventor： DWORRAK, Alexandra ,  ELLINGER, Thomas ,  ERMANTRAUT, Eugen ,  SCHULZ, Torsten ,  ULLRICH, Thomas ,  KAISER, Thomas ,  BICKEL, Ralf

IPC: G01N21/03 ,  B01L3/00 ,  C12Q1/68 ,  G01N21/64 ,  B01L7/00

CPC classification number: B01L3/502738 ,  B01L3/50851 ,  B01L7/52 ,  B01L7/525 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/0864 ,  B01L2300/0877 ,  B01L2300/1827 ,  B01L2300/1838 ,  B01L2400/0481 ,  G01N21/6428 ,  G01N21/6452 ,  G01N2201/024

Abstract: Die Erfindung betrifft Vorrichtungen und Verfahren zum Nachweis von spezifischen Wechselwirkungen zwischen Sonden- und Targetmolekülen.
Insbesondere betrifft die Erfindung eine Vorrichtung zum qualitativen und/oder quantitativen Nachweis von molekularen Wechselwirkungen zwischen Sonden- und Targetmolekülen, umfassend:
a) einen Mikroarray mit einem Substrat, auf dem auf Array-Elementen Sondenmoleküle immobilisiert sind, wobei der Mikroarray auf einer ersten Fläche der Vorrichtung angeordnet ist; und
b) eine Reaktionskammer, die zwischen der ersten Fläche mit dem darauf angeordneten Mikroarray und einer zweiten Fläche gebildet ist,
wobei der Abstand zwischen dem Mikroarray und der zweiten Fläche veränderbar ist.
Anstelle einer einzigen Reaktionskammer sind mehrere Unterkammern vorgesehen, wobei die Abtrennungen zwischen den Unterkammern nicht bis zur zweiten Fläche hochgezogen sind, so dass zwischen den Unterkammern im nicht komprimierten Zustand der Reaktionskammer eine fluidische Verbindung besteht.
Durch Komprimierung der Reaktionskammer können die Unterkammern voneinander abgetrennt werden. Damit lassen sich die Zwischenwände zwischen den Unterkammern durch Zusammenpressen wie Ventile handhaben.

Abstract translation: 本发明涉及用于检测探针和靶分子之间的特异性相互作用的装置和方法。 特别地，本发明涉及一种用于探测和目标分子之间的分子相互作用的定性和/或定量检测的装置，包括：a）具有在其上的阵列元件的探针分子的基板的微阵列被固定，其特征在于，上的一个第一表面上的微阵列 设备安排; 和b），其在第一表面之间形成与微阵列反应室设置在其上和一第二表面，其中所述微阵列与所述第二表面之间的距离是可变的。 代替单个反应室，提供了多个子室，其中子室之间的间隔不会被拉到第二表面，从而在反应室的未压缩状态下子室之间存在流体连接。 通过压缩反应室，子室可以彼此分离。 因此，子腔室之间的中间壁可以通过一起压缩成阀来处理。

公开(公告)号：EP2909600A4

公开(公告)日：2016-09-14

申请号：EP13846416

申请日：2013-10-08

Applicant: VUV ANALYTICS INC

Inventor： HARRISON DALE A ,  HAYES ANTHONY T ,  WALSH PHILLIP

IPC: G01N21/15 ,  G01J3/02 ,  G01N21/03 ,  G01N21/05 ,  G01N21/33 ,  G01N30/74 ,  G01N33/00

CPC classification number: G01N30/78 ,  G01J3/02 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/15 ,  G01N21/33 ,  G01N30/02 ,  G01N30/74 ,  G01N33/0004 ,  G01N33/0027 ,  G01N2021/0325 ,  G01N2021/151 ,  G01N2021/158 ,  G01N2021/335 ,  G01N2030/025 ,  G01N2030/027 ,  G01N2201/024 ,  G01N2201/0633 ,  G01N2201/12 ,  G01N30/7266

Abstract: An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples. Vacuum ultra-violet wavelengths may be utilized. Some of the disclosed techniques can be used for detecting the presence of trace concentrations of gaseous species. A preferable gas flow cell is disclosed. Some of the disclosed techniques may be used with a gas chromatography system so as to detect and identify species eluted from the column. Some of the disclosed techniques may be used in conjunction with an electrospray interface and a liquid chromatography system so as to detect and identify gas phase ions of macromolecules produced from solution. Some of the disclosed techniques may be used to characterize chemical reactions. Some of the disclosed techniques may be used in conjunction with an ultra short-path length sample cell to measure liquids.

Abstract translation: 提供了一种有效的吸收光谱系统。 光谱系统可以被配置为测量固体，液体或气体样品。 可以使用真空紫外波长。 所公开的技术中的一些可用于检测痕量浓度的气态物质的存在。 公开了一种优选的气体流通池。 所公开的技术中的一些可以与气相色谱系统一起使用，以便检测和鉴定从柱洗脱的物质。 所公开的技术中的一些可以与电喷雾界面和液相色谱系统结合使用，以便检测和鉴定由溶液产生的大分子的气相离子。 一些所公开的技术可用于表征化学反应。 所公开的技术中的一些可以与超短路长度样品池结合使用以测量液体。