公开(公告)号：EP2350266B1

公开(公告)日：2015-07-29

申请号：EP09827049.9

申请日：2009-11-19

Applicant: Mesoblast, Inc.

Inventor： ITESCU, Silviu ,  KRISHNAN, Ravi

IPC: C12N5/077 ,  A61P1/18 ,  A61P5/48 ,  A61K35/12 ,  A61K35/39 ,  C12N5/02

CPC classification number: A61K35/545 ,  A61K35/12 ,  A61K45/06 ,  C12N5/0676 ,  G01N33/66 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/47 ,  G01N2333/62 ,  G01N2800/042

Abstract: The present invention provides a method for improving pancreatic function in a subject in need thereof, the method comprising administering to the subject STRO-1 + cells and/or progeny cells thereof and/or soluble factors derived therefrom. The method of the invention is useful for treating and/or preventing and/or delaying the onset or progression of a disorder resulting from or associated with pancreatic dysfunction, e.g., resulting from abnormal endocrine or exocrine function of the pancreas.

公开(公告)号：EP2895512A1

公开(公告)日：2015-07-22

申请号：EP13765328.3

申请日：2013-09-12

Applicant: Neurimmune Holding AG

Inventor： GRIMM, Jan ,  HEITZ, Fabrice ,  CHENG, Feng ,  COMBALUZIER, Ioana

IPC: C07K16/18 ,  G01N33/577 ,  G01N33/68 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K2039/505 ,  C07K7/06 ,  C07K14/4711 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/92 ,  G01N33/54306 ,  G01N33/577 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4709 ,  G01N2800/042 ,  G01N2800/52 ,  G01N2800/56

Abstract: Provided are novel human islet amyloid polypeptide, also known as amylin and IAPP and proIAPP respectively, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for IAPP and/or proIAPP are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for IAPP and/or proIAPP targeted immunotherapy and diagnostics, respectively.

Abstract translation: 本发明提供新颖的人胰岛淀粉样多肽，即称为胰岛淀粉样多肽和分别IAPP和proIAPP，特异性抗体以及其片段，衍生物和变体以及方法与其相关。 检测试剂盒，并与特定的IAPP和/或抗体proIAPP固体载体是如此的游离缺失盘。 的抗体，免疫球蛋白链（一个或多个），以及结合片段，衍生物和变体可在用于IAPP和/或药物proIAPP和诊断组合物可用于分别靶向免疫治疗和诊断。

公开(公告)号：EP2654793A4

公开(公告)日：2015-07-22

申请号：EP11852145

申请日：2011-12-21

Applicant: LEIDOS INC

Inventor： DRESIOS JOHN ,  GRIFFEY RICHARD

IPC: A61K39/44 ,  G01N33/50 ,  G01N33/567

CPC classification number: G01N33/6887 ,  A61K9/1271 ,  A61K38/02 ,  A61K38/1777 ,  A61K39/44 ,  A61K47/42 ,  A61K47/48376 ,  A61K47/48384 ,  A61K47/48415 ,  A61K47/48553 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6811 ,  A61K47/6847 ,  A61K49/0058 ,  C07K16/18 ,  G01N33/5088 ,  G01N33/567 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2333/4712 ,  G01N2333/78

Abstract: The present disclosure relates to methods for identifying proteins or peptide motifs of intracellular, extracellular, or extracellular matrix proteins specifically exposed in wound sites, as well as compositions for treating wounds, and methods for their use.

Abstract translation: 本公开涉及用于鉴定特异性暴露于伤口部位的细胞内，细胞外或细胞外基质蛋白的蛋白质或肽基序的方法，以及用于治疗伤口的组合物及其使用方法。

公开(公告)号：EP2883052A1

公开(公告)日：2015-06-17

申请号：EP13753421.0

申请日：2013-08-12

Applicant: Instituto Superiore Di Sanita'

Inventor： LAVIOLA, Giovanni ,  ADRIANI, Walter ,  PORFIRIO, Maria Cristina ,  CURATOLO, Paolo ,  GRANSTREM, Oleg

IPC: G01N33/564 ,  C07K14/47

CPC classification number: G01N33/564 ,  C07K14/47 ,  G01N2333/47 ,  G01N2800/305 ,  G01N2800/50 ,  G01N2800/52

Abstract: Methods for detecting autoantibodies against fragments of human dopamine transporter (hDAT)- in biological fluids enable the clinical diagnosis and monitoring of the treatment of ADHD, and is capable of differentiating between ADHD and other "ADHD-like" syndromes.

Abstract translation: 用于检测生物体液中针对人多巴胺转运蛋白片段（hDAT）的自身抗体的方法使得能够临床诊断和监测ADHD的治疗，并且能够区分ADHD和其他“ADHD样”综合征。

公开(公告)号：EP2776588A4

公开(公告)日：2015-06-03

申请号：EP12857972

申请日：2012-12-14

Applicant: US HEALTH

Inventor： PORTER FORBES D III ,  CLUZEAU CELINE V M ,  WATKINS-CHOW DAWN E ,  WASSIF CHRISTOPHER A ,  PAVAN WILLIAM J

IPC: C12Q1/68 ,  C12N15/11 ,  G01N33/50

CPC classification number: G01N33/6893 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/573 ,  G01N2333/47 ,  G01N2333/96475 ,  G01N2800/04 ,  G01N2800/044

公开(公告)号：EP2873975A1

公开(公告)日：2015-05-20

申请号：EP13817636.7

申请日：2013-07-10

Applicant: Riken

Inventor： MIYAWAKI, Atsushi ,  HAMA, Hiroshi

IPC: G01N33/531 ,  G01N33/53

CPC classification number: G01N33/5306 ,  C07K16/18 ,  G01N33/6854 ,  G01N2333/47 ,  G01N2800/28

Abstract: An antibody composition, which is an aspect of the present invention, contains at least one compound selected from the group consisting of urea and urea derivatives, the compound being contained in the antibody composition at a concentration of not less than 0.1 M and less than 1 M, the antibody composition being a solution.

Abstract translation: 作为本发明的一个方面的抗体组合物含有至少一种选自脲和脲衍生物的化合物，该抗体组合物中所含的化合物浓度不小于0.1M且小于1 M，抗体组合物为溶液。

公开(公告)号：EP2811018A4

公开(公告)日：2015-05-13

申请号：EP13743114

申请日：2013-02-01

Applicant: SHIONOGI & CO

Inventor： TAKAHASHI TATSUYA ,  ONODA JUNJI ,  YOSHIDA YASUNOBU ,  YAMANE SHOJI ,  NISHITOMI KOUHEI ,  YAMAKAWA HIDEKUNI ,  YAMAUCHI AKIRA ,  MORITA ATSUSHI ,  FUKUDA ISAO

IPC: C12N15/09 ,  C07K16/18 ,  C12P21/08 ,  G01N33/15 ,  G01N33/50 ,  G01N33/53

CPC classification number: G01N33/6896 ,  C07K16/18 ,  C07K2317/30 ,  C07K2317/565 ,  G01N2333/47 ,  G01N2333/4709 ,  G01N2333/96475 ,  G01N2500/00 ,  G01N2800/28

公开(公告)号：EP2750606A4

公开(公告)日：2015-04-29

申请号：EP12833356

申请日：2012-09-19

Applicant: C2N DIAGNOSTICS

Inventor： WEST TIM ,  PAOLETTI ANDREW C

IPC: A61B6/00 ,  G01N33/534 ,  G01N33/68 ,  G01T1/00

CPC classification number: G01N33/6896 ,  G01N2333/47 ,  G01N2500/04 ,  G01N2800/28 ,  G01N2800/2821 ,  G01N2800/2835 ,  G01N2800/2871 ,  G01N2800/52

Abstract: Methods for the diagnosis, prognosis, treatment and determining the efficacy of a therapeutic regimen for neurological and neurodegenerative diseases, disorders, and associated processes include using a detectable label to measure levels of alpha-synuclein.

公开(公告)号：EP2863225A1

公开(公告)日：2015-04-22

申请号：EP14193244.2

申请日：2010-05-18

Applicant: Washington University

Inventor： Kharasch, David Evan ,  Morrissey, Jeremiah J

IPC: G01N33/574

CPC classification number: G01N33/57438 ,  G01N2333/47

Abstract: Disclosed are methods for detecting, diagnosing or monitoring a renal cancer in a subject. The methods include detecting quantity of one or more polypeptides or fragments thereof comprised by body fluid such as urine, wherein the one or more polypeptides or fragments thereof, can be present at elevated levels in a subject with a kidney cancer, as compared to a subject without a kidney cancer. Non-limiting examples of such polypeptides include aquaporin-1, adipose differentiation-related protein and paired box protein-2. Antibody probes can be used to detect or quantify the polypeptides. In some embodiments, mass spectroscopy can be used to detect or quantify the polypeptides, or to identify a polypeptide in a body fluid sample from a subject with a kidney cancer.

Abstract translation: 公开了用于检测，诊断或监测受试者中的肾癌的方法。 所述方法包括检测由体液如尿液组成的一种或多种多肽或其片段的量，其中与受试者相比，一种或多种多肽或其片段可以以较高水平存在于患有肾癌的受试者中 没有肾癌。 此类多肽的非限制性实例包括水通道蛋白-1，脂肪分化相关蛋白和配对盒蛋白-2。 抗体探针可用于检测或定量多肽。 在一些实施方案中，质谱可用于检测或定量多肽，或鉴定来自患有肾癌的受试者的体液样品中的多肽。

公开(公告)号：EP2861992A1

公开(公告)日：2015-04-22

申请号：EP13807372.1

申请日：2013-06-17

Applicant: The University of North Carolina at Chapel Hill

Inventor： HAYES, David, N. ,  WILKERSON, Matthew, D. ,  WALTER, Vonn, A. ,  ZHAO, Ni

IPC: G01N33/574 ,  G01N33/48 ,  C12Q1/68

CPC classification number: G01N33/5743 ,  C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16 ,  G01N33/57484 ,  G01N33/6875 ,  G01N2333/47

Abstract: This invention is directed to improved methods for determining the prognosis of patients with head and neck cancer. The invention is also directed to kits comprising reagents useful for determining head and neck cancer prognosis.