CUSTOMIZED MOLECULARLY IMPRINTED POLYMER (MIP) UNITS
    64.
    发明公开
    CUSTOMIZED MOLECULARLY IMPRINTED POLYMER (MIP) UNITS 审中-公开
    MASSGESCHNEIDERTE EINHEITEN AUD MOLEKULARGEPRÄGTEMPOLYMER(MIP)

    公开(公告)号:EP2396349A1

    公开(公告)日:2011-12-21

    申请号:EP10705837.2

    申请日:2010-02-10

    Abstract: A method of manufacturing at least one customized MIP unit comprising: (a) providing at least one MIP unit having a surface comprising at least one target binding site configured to resemble a target molecule and surface-bound chargeable groups; (b) contacting the MIP unit(s) from the step (a) with at least one template molecule in a first solvent allowing the template molecule (s) to bind to the MIP unit(s); (c) passivating the surface-bound chargeable groups on the MIP unit(s) by adding a passivating agent; and (d) removing the template molecule (s) by washing in a second solvent, wherein the passivating agent binds to the surface of the unit(s) through bonds which remain stable upon washing in the second solvent.

    Abstract translation: 一种制造至少一个定制的MIP单元的方法,包括:(a)提供至少一个MIP单元,其具有包括至少一个目标结合位点的表面,所述靶结合位点被配置为类似于目标分子和表面结合的可带电基团; (b)使来自步骤(a)的MIP单元与第一溶剂中的至少一个模板分子接触,允许模板分子与MIP单元结合; (c)通过添加钝化剂钝化MIP单元上的表面结合的可充电基团; 和(d)通过在第二溶剂中洗涤除去模板分子,其中钝化剂通过在第二溶剂中洗涤时保持稳定的键而与单元的表面结合。

    CROSSLINKABLE POLY(OXYALKYLENE)-CONTAINING POLYAMIDE PREPOLYMERS
    67.
    发明公开
    CROSSLINKABLE POLY(OXYALKYLENE)-CONTAINING POLYAMIDE PREPOLYMERS 有权
    交联Polyamidprepolymere,含聚氧化烯

    公开(公告)号:EP1817362A1

    公开(公告)日:2007-08-15

    申请号:EP05807368.5

    申请日:2005-11-21

    Abstract: The present invention provides a water-soluble crosslinkable poly(oxyalkylene)­containing prepolymer. The crosslinkable poly(oxyalkylene)-containing copolymer prepolymer of the invention is prepared by reacting an amine-capped poly(oxyalkylene)­containing polyamide with a multifunctional compound having at least one one ethylenically unsaturated group and a function group coreactive with the capping amine groups of the amine-capped poly(oxyalkylene)-containing polyamide. The amine-capped poly(oxyalkylene)-containing polyamide is a copolymerization production of a mixture comprising: (a) at least one poly(oxyalkylene)diamine, (b) optionally at least one organic di­or poly-amine, (c) at least one dicarboxyl derivative, (d) optionally at least one polycarboxyl derivative, and (e) a carbodiimide. The crosslinkable poly(oxyalkylene)-containing prepolymer of the invention can find use in economically producing contact lenses which have improved thermal stability. In addition, the present invention provides method for making a medical device, preferably an ophthalmic device, more preferably a contact lens.

    PROCESS FOR THE COVALENT SURFACE MODIFICATION OF HYDROPHOBIC POLYMERS AND ARTICLES MADE THEREFROM
    70.
    发明授权
    PROCESS FOR THE COVALENT SURFACE MODIFICATION OF HYDROPHOBIC POLYMERS AND ARTICLES MADE THEREFROM 失效
    疏水性聚合物和产品的方法共价表面修饰物

    公开(公告)号:EP0520979B1

    公开(公告)日:1999-01-13

    申请号:EP89912861.5

    申请日:1989-10-16

    Applicant: HEMASURE, INC.

    CPC classification number: C08F8/00 Y10S436/824 Y10S530/815 Y10S530/816

    Abstract: The covalent modification of a hydrophobic polymer surface by a process which utilizes the functionalizable chain ends of the hydrophobic polymer is disclosed. The process of the invention is conveniently carried out under heterogeneous conditions, allowing the practitioner to take full advantage of the general processability, strength, and other desirable characteristics of a hydrophobic polymer used in the production of a manufactured article. The invention is most advantageously applied to the surface modification of microporous membranes, allowing the practitioner to choose from a vast range of possible surface macromolecular species which may be covalently bound to the membrane polymer chain ends. The process of the invention proceeds without a significant reduction in the pore dimensions or hydraulic permeability of the original unmodified membrane. This invention also discloses a four-component dope composition which exhibits surprising and useful thermal phase separation characteristics which can be exploited in a manufacturing process disclosed herein. A spinnerette assembly which greatly facilitates the efficiency and versatility of said process is also described.

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