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公开(公告)号：EP0261759A2
公开(公告)日：1988-03-30
申请号：EP87304181.8
申请日：1987-05-11
IPC分类号： C07C259/10 , A61K31/165
CPC分类号： C07C59/90
摘要： The synthesis of amido substituted naphthalenes and their intermediates is described. The intermediates and amido substituted naphthalenes are useful as anti-inflammatory agents.
摘要翻译： 描述酰胺取代萘及其中间体的合成。 中间体和酰胺取代的萘可用作抗炎剂。
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公开(公告)号：EP4397656A3
公开(公告)日：2024-10-09
申请号：EP24162940.1
申请日：2018-04-11
IPC分类号： C07C259/10 , C07C259/06 , A61K31/16 , A61K51/04 , A61P25/28 , C07D213/79 , C07D239/42
CPC分类号： A61K51/04 , C07C259/10 , C07C2602/4220170501 , C07C2603/7420170501 , G01N33/573 , G01N2800/5220130101 , A61P25/28 , C07D239/42 , C07D213/79
摘要： Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.
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公开(公告)号：EP4074692A1
公开(公告)日：2022-10-19
申请号：EP20898053.2
申请日：2020-12-08
发明人： MINOURA, Mao , SUGAMATA, Koh , IIHAMA, Teruyuki
IPC分类号： C07C259/10 , C07F1/08 , C07F3/02 , C07F3/06 , C07F15/04 , C07F15/06 , F17C11/00 , C01B3/00 , C07D213/60 , C07D213/81 , C07D487/04 , B01J20/26
摘要： It is an object of the present invention to provide a storage material for a gas such as hydrogen, carbon dioxide, methane, or acetylene (excluding nitrogen gas) comprising a metal-organic framework comprising a hydroxamic acid group as a bonding site. A metal-organic framework comprising a multivalent metal ion and a molecule comprising an unsubstituted or substituted hydroxamic acid group and one or more sites capable of being bonded to the multivalent metal ion is contained. The molecule is preferably at least one compound selected from the group consisting of compounds of formulas (I) to (III).
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公开(公告)号：EP3400210B1
公开(公告)日：2021-09-29
申请号：EP17701176.4
申请日：2017-01-05
IPC分类号： C07C259/06 , A61K31/16 , A61K31/165 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/47 , A61K31/517 , A61K45/06 , C07C259/10 , C07D213/81 , C07D215/14 , C07D239/74 , C07C235/38 , C07C235/64 , C07D209/42 , C07D209/86 , C07D213/65 , A61P35/00
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公开(公告)号：EP3484852B1
公开(公告)日：2020-04-08
申请号：EP17737833.8
申请日：2017-07-14
申请人： Italfarmaco SpA
发明人： STEVENAZZI, Andrea , SANDRONE, Giovanni , MODENA, Daniela , POZZI, Pietro, Samuele , VERGANI, Barbara , LATTANZIO, Maria , MASCAGNI, Paolo , STEINKÜHLER, Christian , FOSSATI, Gianluca
IPC分类号： C07D215/14 , C07C259/10 , C07D317/60 , C07D405/12 , C07D407/12 , C07D209/18 , C07D213/56 , A61K31/16 , A61K31/36 , A61K31/438 , A61K31/4406 , A61P35/00 , C07D213/643 , C07D233/64
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公开(公告)号：EP3484852A1
公开(公告)日：2019-05-22
申请号：EP17737833.8
申请日：2017-07-14
申请人： Italfarmaco SpA
发明人： STEVENAZZI, Andrea , SANDRONE, Giovanni , MODENA, Daniela , POZZI, Pietro, Samuele , VERGANI, Barbara , LATTANZIO, Maria , MASCAGNI, Paolo , STEINKÜHLER, Christian , FOSSATI, Gianluca
IPC分类号： C07D215/14 , C07C259/10 , C07D317/60 , C07D405/12 , C07D407/12 , C07D209/18 , C07D213/56 , A61K31/16 , A61K31/36 , A61K31/438 , A61K31/4406 , A61P35/00 , C07D213/643 , C07D233/64
摘要： The present invention relates to new benzo-N-hydroxy amide compounds of formula (I) and pharmaceutically acceptable salts thereof, which show a significant inhibitory activity on the proliferation of tumor cells and specifically of cancer stem cells.
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公开(公告)号：EP3400210A2
公开(公告)日：2018-11-14
申请号：EP17701176.4
申请日：2017-01-05
IPC分类号： C07C259/06 , A61K31/16 , A61K31/165 , A61K31/403 , A61K31/404 , A61K31/44 , A61K31/47 , A61K31/517 , A61K45/06 , C07C259/10 , C07D213/81 , C07D215/14 , C07D239/74 , C07C235/38 , C07C235/64 , C07D209/42 , C07D209/86 , C07D213/65 , A61P35/00
CPC分类号： C07C259/06 , A61K45/06 , C07C235/38 , C07C235/64 , C07C259/10 , C07D209/42 , C07D209/86 , C07D213/65 , C07D213/81 , C07D215/14 , C07D239/74
摘要： The present invention relates to the design of new molecules, referred to as "multi-target" molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDAC) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the "multi-target" molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one "multi-target" molecule, and the use of such compositions in the treatment of cancer.
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公开(公告)号：EP3331865A1
公开(公告)日：2018-06-13
申请号：EP16751327.4
申请日：2016-08-05
IPC分类号： C07D401/04 , C07C259/10
CPC分类号： C07D243/26 , C07C259/10 , C07C271/28 , C07D401/04
摘要： The invention relates to processes for the synthesis of benzodiazepine derivatives of Formula I: (I)
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公开(公告)号：EP2682383A4
公开(公告)日：2015-12-09
申请号：EP12752248
申请日：2012-02-28
发明人： SHIMADA YUKIHISA , KIKUZATO KO , NARUKAWA MEGUMI , ASAMI TADAO , SOENO KAZUO
IPC分类号： C07C239/20 , A01G7/06 , A01N37/36 , A01N37/44 , A01P13/00 , A01P21/00 , C07C243/38 , C07C251/60 , C07C259/06 , C07C259/10 , C07D207/46 , C07D209/48 , C07D215/14 , C07D295/14
CPC分类号： A01N43/60 , A01N37/10 , A01N37/28 , A01N37/36 , A01N37/38 , A01N37/44 , A01N43/20 , A01N43/38 , A01N43/42 , C07C239/20 , C07C243/38 , C07C251/60 , C07C259/06 , C07C259/10 , C07D207/46 , C07D209/48
摘要： An object of the present invention is to provide an auxin biosynthesis inhibitor superior to L-AOPP. The object can be attained by a compound represented by general formula (I): wherein, R 1 to R 5 and X are the same as defined in the specification or a salt or solvate thereof.
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公开(公告)号：EP1973872A4
公开(公告)日：2012-05-09
申请号：EP07855542
申请日：2007-12-19
申请人： METHYLGENE INC
发明人： DEZIEL ROBERT , AJAMIAN ALAIN
IPC分类号： C07C311/21 , A61K31/10 , A61K31/16 , A61K31/17 , A61K31/18 , A61K31/34 , A61K31/381 , A61K31/433 , A61K31/435 , A61P35/00 , C07C259/10 , C07C275/42 , C07C317/44 , C07D285/135 , C07D307/54 , C07D333/34 , C07D333/62
CPC分类号： C07C311/21 , C07C259/06 , C07C259/10 , C07C275/42 , C07C279/14 , C07C311/13 , C07C311/29 , C07C311/44 , C07C313/06 , C07C317/44 , C07C2601/02 , C07C2601/04 , C07D213/30 , C07D213/70 , C07D215/24 , C07D235/02 , C07D271/08 , C07D285/135 , C07D307/91 , C07D309/06 , C07D317/30 , C07D317/60 , C07D333/34 , C07D333/62 , C07D409/04
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