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公开(公告)号：EP2968210B1
公开(公告)日：2024-09-11
申请号：EP14762362.3
申请日：2014-03-07
IPC分类号： A61K31/27 , A61K31/325 , A61P25/08
CPC分类号： A61K31/03 , A61K31/27 , C07C2601/0220170501 , C07C2602/4220170501 , C07C2601/1420170501 , A61K31/325 , A61P21/00 , A61P21/02 , A61P25/00 , A61P25/08 , A61P25/10 , A61P25/12 , A61P25/16
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公开(公告)号：EP4405355A1
公开(公告)日：2024-07-31
申请号：EP22868510.3
申请日：2022-09-20
IPC分类号： C07D471/04 , A61K31/194 , A61K31/198 , A61K31/375 , A61K31/4745 , A61P25/00 , A61P25/18 , A61P25/24 , C07C59/255 , C07C229/24 , C07D307/62
CPC分类号： A61P25/18 , A61P25/24 , A61P25/00 , C07C59/255 , C07C229/24 , C07C2602/4220170501 , C07C309/19 , C07C309/30 , C07C309/05 , C07D471/06
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公开(公告)号：EP4405325A1
公开(公告)日：2024-07-31
申请号：EP22782501.5
申请日：2022-09-19
IPC分类号： C07C209/84 , C07C263/10 , C07C211/09 , C07C211/12 , C07C211/36 , C07C211/27 , C07C211/18 , C07C265/14 , C08G69/26
CPC分类号： C07C209/84 , C07C2601/1420170501 , C07C2602/4220170501 , C07C263/10 , C08G69/26
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公开(公告)号：EP4423058A1
公开(公告)日：2024-09-04
申请号：EP22835522.8
申请日：2022-10-28
发明人： SHAW, Scott A. , CLARKE, Adam James , FRIENDS, Todd J. , MATHUR, Arvind , MYERS, Michael C. , LI, Jianqing , PABBISETTY, Kumar Balashanmuga , SU, Shun , TORA, George O. , VOKITS, Benjamin P. , WURTZ, Nicholas R. , PINTO, Donald J.P. , PASUNOORI, Laxman
IPC分类号： C07C237/24 , C07C255/41 , C07C271/22 , C07C271/24 , C07C271/28 , C07C311/29 , C07C317/28 , C07C317/30 , C07C317/46 , C07D205/12 , A61K31/166 , A61P9/04
CPC分类号： C07C2601/0420170501 , C07C2601/1420170501 , C07C2602/4220170501 , C07C237/24 , C07C2601/0220170501 , C07C317/30 , C07D205/12 , C07C2602/2220170501 , C07C2601/0820170501 , C07C271/28 , C07C317/46 , C07C311/29 , C07C2602/2020170501 , C07C2601/1020170501 , C07C2603/7020170501 , C07C2602/0820170501 , C07C317/28 , C07C2602/5020170501 , C07C255/41 , C07C271/24 , C07C271/22 , C07C2602/1620170501 , A61P9/04 , C07D205/04 , C07D309/08 , C07D213/68 , C07D249/06 , C07D211/46 , C07D295/155 , C07D305/06 , C07D235/26 , C07D233/72 , C07D307/20 , C07D207/12 , C07D309/04 , C07D307/16 , C07D309/22 , C07D263/22 , C07D207/26 , C07D307/22 , C07D295/26 , C07D265/30 , C07D241/04 , C07D491/048 , C07D257/06 , C07D498/04 , C07D207/16 , C07D487/04 , C07D498/08 , C07D495/10 , C07D211/54 , C07D491/107 , C07D207/10 , C07D295/192 , C07D307/32 , C07D317/72 , C07D309/12 , C07D249/08 , C07D261/20 , C07D295/185 , C07D211/18 , C07D277/22
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5.发明公开
公开(公告)号：EP4412974A1
公开(公告)日：2024-08-14
申请号：EP22802288.5
申请日：2022-10-07
CPC分类号： C07C43/23 , A61P29/00 , C07C2602/4220170501 , A61K31/085 , Y02A50/30
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公开(公告)号：EP4356971A2
公开(公告)日：2024-04-24
申请号：EP23213609.3
申请日：2017-05-05
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qingwei , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： A61P35/00
CPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07C311/13 , C07D401/04 , C07C311/24 , C07D237/14 , C07D237/16 , C07C317/22 , C07D405/08 , C07D241/18 , C07D261/08 , C07D261/20 , C07C235/22 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , C07C2602/3820170501 , C07C2602/4020170501 , C07C2602/4220170501 , C07C2602/4420170501 , C07C2603/9020170501 , C07D471/04 , A61P25/28
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：EP3521409B1
公开(公告)日：2024-08-14
申请号：EP19164800.5
申请日：2015-03-26
IPC分类号： C11B9/00 , A23L27/20 , C07C33/025
CPC分类号： A61Q13/00 , C07C49/20 , C11B9/0019 , C11B9/003 , C11B9/0049 , C11B9/0061 , C07D307/00 , A61K8/8158 , A61K8/8164 , A61K8/88 , C07C47/47 , C07C49/255 , C07C69/07 , C07C69/145 , C07C251/40 , C07C233/58 , C07C2601/0220170501 , C07C2601/0420170501 , C07C2601/0620170501 , C07C2601/0820170501 , C07C2601/1020170501 , C07C2601/1620170501 , C07C2602/4220170501 , C07C2603/6020170501 , C11B9/0088 , C07D307/36 , C07D319/06 , C07D319/08 , C07C255/07 , C07C255/46 , C07C69/75 , C07C69/14 , C07C49/203 , C07C33/025 , C07C49/21 , C07C33/14 , C07C47/42 , C11B9/0076 , C11B9/008 , C11B9/0023 , C11B9/0034 , C11B9/0015 , C11D3/50 , A61Q11/00 , A61Q5/02 , C07D309/04 , C07D493/08
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公开(公告)号：EP3901128B1
公开(公告)日：2024-07-31
申请号：EP20382329.9
申请日：2020-04-22
IPC分类号： C07C45/34 , C07C49/647 , C07C49/643 , C07C49/637 , C07C49/617
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公开(公告)号：EP4356971A3
公开(公告)日：2024-07-24
申请号：EP23213609.3
申请日：2017-05-05
发明人： SIDRAUSKI, Carmela , PLIUSHCHEV, Marina , FROST, Jennifer, M. , BLACK, Lawrence, A. , XU, Xiangdong , SWEIS, Ramzi, Farath , SHI, Lei , ZHANG, Qingwei , TONG, Yunsong , HUTCHINS, Charles, W. , CHUNG, Seungwon , DART, Michael, J.
IPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07D401/04 , C07D237/14 , C07D237/16 , C07D405/08 , C07D241/18 , C07D471/04 , C07D261/08 , C07D261/20 , C07C235/00 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , A61K31/44 , A61P35/00
CPC分类号： C07D213/73 , C07D317/64 , C07D231/56 , C07C311/13 , C07D401/04 , C07C311/24 , C07D237/14 , C07D237/16 , C07C317/22 , C07D405/08 , C07D241/18 , C07D261/08 , C07D261/20 , C07C235/22 , C07D271/113 , C07D213/30 , C07D213/64 , C07D213/66 , C07C2602/3820170501 , C07C2602/4020170501 , C07C2602/4220170501 , C07C2602/4420170501 , C07C2603/9020170501 , C07D471/04 , A61P25/28
摘要： Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
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公开(公告)号：EP4397656A2
公开(公告)日：2024-07-10
申请号：EP24162940.1
申请日：2018-04-11
IPC分类号： C07D239/42
CPC分类号： A61K51/04 , C07C259/10 , C07C2602/4220170501 , C07C2603/7420170501 , G01N33/573 , G01N2800/5220130101 , A61P25/28 , C07D239/42 , C07D213/79
摘要： Provided herein are compounds useful for binding to one or more histone deacetylase enzymes (HDACs). The present application further provides radiolabeled compounds useful as a radiotracer for position emission tomography imaging of HDAC. Methods for prepared unlabeled and labeled compounds, diagnostic methods, and methods of treating diseases associated HDAC are also provided.
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