公开(公告)号：EP2911661A4

公开(公告)日：2016-07-20

申请号：EP13849415

申请日：2013-10-28

申请人： UNIV HONG KONG CHINESE

发明人： LAN HUI YAO

IPC分类号： A61K31/713 ,  A61K31/4725 ,  A61K31/7105 ,  A61P35/00

CPC分类号： A61K31/4725 ,  A61K9/0019 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K38/00 ,  A61K39/3955

摘要： The present invention resides in the discovery that Smad3, a key downstream mediator of TGF-² signaling, plays a critical role in development and progression of cancer. Thus, this application provides for a novel method of treating cancer by inhibiting Smad3 signaling, such as through administration of SIS3, an inhibitor of Smad3. Further provided are compositions and kits useful for treating cancer by way of inhibiting Smad3 signaling.

摘要翻译： 本发明在于发现Smad3是TGF-β的关键下游介质。 信号，在癌症的发展和进展中发挥关键作用。 因此，本申请提供了通过抑制Smad3信号传导来治疗癌症的新方法，例如通过施用Smad3抑制剂SIS3。 还提供了可用于通过抑制Smad3信号传导治疗癌症的组合物和试剂盒。

公开(公告)号：EP2864501A4

公开(公告)日：2016-03-16

申请号：EP13807105

申请日：2013-06-14

申请人： UNIV HONG KONG CHINESE

发明人： CHIU WAI KWUN ROSSA ,  LO YUK-MING DENNIS ,  CHAN KWAN CHEE ,  JIANG PEIYONG

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q2600/112 ,  C12Q2600/156 ,  C12Q2535/122 ,  C12Q2537/16 ,  C12Q2539/107

摘要： A frequency of somatic mutations in a biological sample (e.g., plasma or serum) of a subject undergoing screening or monitoring for cancer, can be compared with that in the constitutional DNA of the same subject. A parameter can derived from these frequencies and used to determine a classification of a level of cancer. False positives can be filtered out by requiring any variant locus to have at least a specified number of variant sequence reads (tags), thereby providing a more accurate parameter. The relative frequencies for different variant loci can be analyzed to determine a level of heterogeneity of tumors in a patient.

摘要翻译： 可以将经历筛选或监测癌症的受试者的生物样品（例如血浆或血清）中的体细胞突变的频率与同一受试者的结构DNA中的体细胞突变的频率进行比较。 一个参数可以从这些频率导出，用于确定癌症水平的分类。 可以通过要求任何变体轨迹至少具有指定数量的变体序列读取（标签）来过滤掉假阳性，从而提供更准确的参数。 可以分析不同变体基因座的相对频率，以确定患者肿瘤异质性水平。

公开(公告)号：EP2661507A4

公开(公告)日：2015-12-23

申请号：EP12732095

申请日：2012-01-05

申请人： UNIV HONG KONG CHINESE

发明人： LO YUK MING DENNIS ,  CHIU WAI KWUN ROSSA ,  CHAN KWAN CHEE ,  TSUI BO YIN

IPC分类号： G06F19/00

CPC分类号： G06F19/18 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158

摘要： Methods, apparatuses, and system are provided for analyzing a maternal sample to determine whether a male fetus of a pregnant female has inherited an X-linked mutation from the mother. A percentage of fetal DNA in the sample is obtained, and cutoff values for the two possibilities (fetus inherits mutant or normal allele) are determined. A proportion of mutant alleles relative to a normal allele on the X-chromosome can then be compared to the cutoff values to make a classification of which allele is inherited. Alternatively, a number of alleles from a target region on the X-chromosome can be compared to a number of alleles from a reference region on the X-chromosome to identify a deletion or amplification. The fetal DNA percentage can be computed by counting reactions with a fetal-specific allele, and correcting the number to account for a statistical distribution among the reactions.

公开(公告)号：EP2828774A4

公开(公告)日：2015-10-14

申请号：EP13765121

申请日：2013-03-22

申请人： UNIV HONG KONG BAPTIST

发明人： LIU JIMING ,  LEUNG CLEMENT HO CHEUNG ,  TAO LI

IPC分类号： G06Q50/22 ,  G06F19/00

CPC分类号： G06Q10/06 ,  G06Q50/22 ,  G16H50/20

摘要： The present invention discloses methods and apparatus for developing, analyzing, investigating, and advising healthcare and well-being related decisions. In particular, the present invention relates to the architecture of systems in either stand-alone or distributed/collaborative/pervasive settings, the components of the systems and their underlying processes and couplings, the computational techniques built into the methods, input data sources integrated into and output results produced and distributed by the systems, as well as the apparatus for carrying out the corresponding user interaction, data access and collection, data integration and processing, data-driven inferences and simulation, intelligent computations, decision analytics, and decision support to generating solutions to various healthcare analytics and decision-making problems. This invention also relates to two working illustrations of the methods and apparatus that present the embodiment illustrations of the present invention.

公开(公告)号：EP2820107A4

公开(公告)日：2015-09-30

申请号：EP13754558

申请日：2013-03-01

申请人： UNIV HONG KONG

发明人： YAM WING WAH VIVIAN ,  TANG MAN CHUNG KOBE ,  CHAN MEI YEE MAGGIE ,  WONG MAN CHUNG KEITH

IPC分类号： C09K11/06 ,  H05B33/14

CPC分类号： H01L51/0084 ,  C07F1/12 ,  C07F7/0809 ,  C07F7/0812 ,  C09K11/06 ,  C09K2211/188 ,  G05D21/00 ,  G06Q10/10 ,  G06Q50/02 ,  H01L51/0072 ,  H01L51/0091 ,  H01L51/0095 ,  H01L51/5012

公开(公告)号：EP2748176A4

公开(公告)日：2015-09-16

申请号：EP12824951

申请日：2012-08-23

申请人： UNIV MCGILL ,  UNIV HONG KONG POLYTECHNIC

发明人： DAMHA MASAD J ,  HASSLER MATTHEW ,  CHAN TAK-HANG ,  REDDY N MALLIKARJUNA ,  DONGA ROBERT ALEXANDER

IPC分类号： C07H21/00 ,  C07D233/60 ,  C07F9/54 ,  C07H19/02 ,  C07H21/02 ,  C40B70/00 ,  C40B80/00

CPC分类号： C07F9/54 ,  C07D233/60 ,  C07F9/5407 ,  C07F9/5442 ,  C07F9/5456 ,  C07F9/65515 ,  C07F9/65586 ,  C07H19/02 ,  C07H21/00 ,  C07H21/02 ,  C40B50/16 ,  C40B80/00

摘要： The invention relates to the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. In another aspect, the invention relates to compounds of formula (II) processes for making these compounds, and the use thereof in the chemical synthesis of oligonucleotides, e.g., oligoribonucleotides. The invention also relates to methods of synthesis of oligomers, including but not limited to oligopeptides, oligosaccharides and oligonucleotides, particularly oligoribonucleotides and also oligodeoxyribonucleotides, in solution systems, and ionic tag linkers for use in methods provided herein.

公开(公告)号：EP2773765A4

公开(公告)日：2015-05-27

申请号：EP12846175

申请日：2012-11-05

申请人： UNIV HONG KONG

发明人： CHYE MEELEN ,  DU ZHIYAN ,  CHEN MOXIAN

IPC分类号： C12N15/82 ,  A01H5/00 ,  C12N1/21

CPC分类号： C12N15/8273

公开(公告)号：EP2750684A4

公开(公告)日：2015-04-15

申请号：EP12823450

申请日：2012-08-17

申请人： UNIV HONG KONG

发明人： SZE CHOWING ,  WONG KAMLOK ,  TONG YAO ,  ZHANG YANBO ,  CHEUNG HOPAN

IPC分类号： A61K36/00 ,  A61K36/8945 ,  A61P5/30 ,  C07K14/415

CPC分类号： C07K14/415 ,  A61K36/8945 ,  A61K38/00

摘要： A protein isolated from the Chinese yam Dioscorea opposita that stimulates estrogen and progesterone release in vitro and in vivo but does not stimulate the proliferation of breast and ovarian cancer cells is disclosed. The protein exhibits anti-osteoporotic activity in vivo. Also provided are the procedure for isolation and purification of the protein and the N-terminal amino acid sequence of the protein.

摘要翻译： 公开了从中国山药薯a分离的蛋白质，其在体外和体内刺激雌激素和孕激素释放，但不刺激乳腺和卵巢癌细胞的增殖。 蛋白质体内表现出抗骨质疏松活性。 还提供了分离和纯化蛋白质和蛋白质的N-末端氨基酸序列的程序。

公开(公告)号：EP2616876A4

公开(公告)日：2015-04-01

申请号：EP10857121

申请日：2010-09-13

申请人： UNIV HONG KONG POLYTECHNIC

发明人： TSE YAN YIN ,  TO CHI HO ,  LAM SIU YIN

IPC分类号： G02C7/04 ,  A61F2/14 ,  A61F9/00 ,  G02C7/06

CPC分类号： G02C7/044 ,  A61F2/14 ,  G02C7/042 ,  G02C7/06 ,  G02C2202/24

摘要： A method for retarding the progression of myopia in a human eye is provided. The method comprises providing (41) a concentric annular multi-zone refractive lens including: at least one correcting zone of optical power for correcting (42) refractive error, and at least one defocusing zone for projecting (43) at least one non-homogenous defocused image in front of at least a part of retina to inhibit myopic eye growth. The at least one defocusing zone has at least one less negative power. The correcting and defocusing zones are alternated (45) in the lens and the zones are connected (46) to each other through integrated progressive transition curves. A system for retarding the progression of myopia in a human eye is also provided.

摘要翻译： 提供了一种延缓人眼近视发展的方法。 该方法包括提供（41）同心环形多区域折射透镜，其包括：用于校正（42）屈光不正的至少一个光学校正区域和至少一个散焦区域，用于将（43）至少一个非均匀的 至少部分视网膜前方散焦图像以抑制近视眼的生长。 至少一个散焦区具有至少一个较小的负功率。 校正和散焦区域在透镜中交替（45），并且区域通过集成的渐进转变曲线彼此连接（46）。 还提供了用于延缓人眼近视进展的系统。

公开(公告)号：EP2644004A4

公开(公告)日：2015-03-25

申请号：EP11842985

申请日：2011-11-17

申请人： UNIV HONG KONG CHINESE

发明人： YANG SHENGHAO ,  YEUNG RAYMOND WAI HO

IPC分类号： H03M13/37 ,  H03M13/11 ,  H03M13/29 ,  H04L1/00

CPC分类号： H03M13/3761 ,  H03M13/1191 ,  H03M13/2906 ,  H03M13/293 ,  H03M13/616 ,  H04L1/0076 ,  H04L2001/0097

摘要： A method for data encoding and associated decoding is based on the concept of batches that allows transmission of a large data file from a source node to multiple destination nodes through communication networks that may employ network coding wherein sparse matrix codes are employed in a network setting. A batch is a set of packets generated by a subset of the input packets using sparse matrix encoder. A sparse matrix encoder can be called repeatedly to generate multiple batches. The batches are generally independent of one another. During the transmission in a communication network, network coding can be applied to packets belonging to the same batch to improve the multicast throughput. A decoder recovers all or at least a fixed fraction of the input packets using received batches. The input packets can be pre-coded using a pre-code before applying sparse matrix codes. The data file can then be reconstructed by further decoding the pre-code.

摘要翻译： 用于数据编码和相关解码的方法是基于允许通过可能采用网络编码的通信网络将大型数据文件从源节点传送到多个目的地节点的批次的概念，其中在网络设置中采用稀疏矩阵码。 批次是使用稀疏矩阵编码器由输入分组的子集生成的一组分组。 可以重复调用稀疏矩阵编码器来生成多个批次。 批次通常彼此独立。 在通信网络的传输过程中，网络编码可以应用于属于同一批次的数据包，以提高组播吞吐量。 解码器使用接收到的批次恢复所有或至少固定分数的输入分组。 在应用稀疏矩阵代码之前，输入分组可以使用预编码进行预编码。 然后可以通过进一步解码预编码来重构数据文件。