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    TARGETED RNA EDITING
    73.
    发明公开
    TARGETED RNA EDITING 审中-公开
    靶向RNA编辑

    公开(公告)号：EP3234134A1

    公开(公告)日：2017-10-25

    申请号：EP15813826.3

    申请日：2015-12-17

    申请人： ProQR Therapeutics II B.V.

    发明人： KLEIN, Bart ,  PLATENBURG, Gerard Johannes

    IPC分类号： C12N15/113

    摘要： RNA editing is achieved using oligonucleotide constructs comprising (i) a targeting portion specific for a target nucleic acid sequence to be edited and (ii) a recruiting portion capable of binding and recruiting a nucleic acid editing entity naturally present in the cell. The nucleic acid editing entity, such as ADAR, is redirected to a preselected target site by means of the targeting portion, thereby promoting editing of preselected nucleotide residues in a region of the target RNA which corresponds to the targeting portion.

    摘要翻译： 使用寡核苷酸构建体实现RNA编辑，所述构建体包含（i）对待编辑的靶核酸序列特异性的靶向部分和（ii）能够结合和招募天然存在于细胞中的核酸编辑实体的招募部分。 诸如ADAR的核酸编辑实体借助于靶向部分被重定向至预选的靶位点，从而促进编码与靶向部分对应的靶RNA区域中的预选核苷酸残基。

    BOTTOM LOADED PEDICLE SCREW
    76.
    发明公开
    BOTTOM LOADED PEDICLE SCREW 审中-公开
    VOM BODEN GELADENE PEDIKELSCHRAUBE

    公开(公告)号：EP3154462A1

    公开(公告)日：2017-04-19

    申请号：EP15734489.6

    申请日：2015-06-12

    申请人： OrthoPediatrics Corp.

    发明人： DANIELS, David, W.

    IPC分类号： A61B17/70

    CPC分类号： A61B17/7037 ,  A61B17/7032 ,  A61B17/7035

    摘要： A pedicle screw includes a tulip head, a rod seat, a screw shank, and a retainer collar. The tulip head has an upper opening disposed in a top end of the tulip head and a lower opening disposed in a bottom end of the tulip head opposite the upper opening. The upper and lower openings form a single cavity extending through the tulip head from a top end to the bottom end. The rod seat is disposed within the cavity of the tulip head and engages a stop extending inwardly from an interior wall of the cavity. The screw shank has a thread disposed along a length of the screw shank and a connector positioned at an upper end. The retainer collar has a pass through aperture, an expansion slit, and is disposed about the connector of the screw shank. Other embodiments are described and claimed.

    摘要翻译： 椎弓根螺钉包括郁金香头，杆座，螺钉柄和保持器套环。 郁金香头部具有设置在郁金香头部顶端的上部开口，下部开口设置在与上部开口相对的郁金香头部的底端。 上开口和下开口形成从顶端到底端延伸穿过郁金香头的单个空腔。 杆座设置在郁金香头部的空腔内并与从空腔的内壁向内延伸的止挡件接合。 螺杆具有沿着螺杆的长度设置的螺纹和位于上端的连接器。 保持器套环具有通过孔，膨胀缝，并且设置在螺杆的连接器周围。 描述和要求保护其他实施例。

    METHOD FOR TREATMENT OF DEMYELINATING CENTRAL NERVOUS SYSTEM DISEASE
    79.
    发明公开
    METHOD FOR TREATMENT OF DEMYELINATING CENTRAL NERVOUS SYSTEM DISEASE 审中-公开
    VERFAHREN ZUR BEHANDLUNG VON DEMYELINISIERENDER ERKRANKUNG DES ZENTRALEN NERVENSYSTEMS

    公开(公告)号：EP3064215A1

    公开(公告)日：2016-09-07

    申请号：EP16155761.6

    申请日：2003-10-16

    申请人： Hunter, Samuel F.

    发明人： Hunter, Samuel F.

    IPC分类号： A61K38/19 ,  A61P25/00 ,  A61P25/28 ,  A61P37/00 ,  C07K14/535 ,  A61K38/21

    CPC分类号： C07K14/535 ,  A61K38/193 ,  A61K38/21 ,  A61K2300/00

    摘要： A method for treating demyelinating central nervous system diseases in a subject that comprises administering to the subject a composition comprising a therapeutically active amount of colony stimulating factor or CSF-like ligand. In a preferred embodiment of the present invention, the CSF is a GM - CSF. In a most preferred embodiment of the present invention, CSF is sargramostim.

    摘要翻译： 一种用于治疗受试者的脱髓鞘性中枢神经系统疾病的方法，其包括向受试者施用包含治疗活性量的集落刺激因子或CSF-样配体的组合物。 在本发明的优选实施方案中，CSF是GM-CSF。 在本发明的最优选实施方案中，CSF是sargramostim。

    METHODS FOR PREPARING INACTIVATED ROTAVIRUS
    80.
    发明公开
    METHODS FOR PREPARING INACTIVATED ROTAVIRUS 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON INAKTIVIERTEM ROTAVIRUS

    公开(公告)号：EP3021867A1

    公开(公告)日：2016-05-25

    申请号：EP14748051.1

    申请日：2014-07-18

    申请人： Novartis Tiergesundheit AG

    发明人： DEKKER, Brent, E. ,  HERBERT, John, M. ,  REIMNITZ, Michael, J.

    IPC分类号： A61K39/12 ,  C12N7/00

    CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/5252 ,  A61K2039/55566 ,  C12N2720/12321 ,  C12N2720/12332 ,  C12N2720/12334 ,  C12N2720/12361

    摘要： Disclosed are methods for production of inactivated rotavirus directly from cell culture supernatants containing active or infectious rotavirus (e.g., bovine rotavirus), without prior isolation or purification of the rotavirus from the cell culture supernatants. In some embodiments, inactivated rotavirus (e.g., bovine rotavirus) is produced by heating a volume of culture supernatant to at least a temperature at which the rotavirus is inactivated. In some embodiments, the rotavirus (e.g., bovine rotavirus) is inactivated once the entire volume is heated to at least a temperature at which the rotavirus is inactivated. In some embodiments, the temperature of the cell culture supernatant is maintained for a suitable amount of time, which may be determined using any of the tests described herein. Inactivated rotavirus (e.g., bovine rotavirus) may then be isolated from the culture supernatant.

    摘要翻译： 公开了直接从含有活性或感染性轮状病毒（例如牛轮状病毒）的细胞培养上清液中生产灭活轮状病毒的方法，没有事先从细胞培养物上清液中分离或纯化轮状病毒。在一些实施方案中，灭活轮状病毒（例如牛轮状病毒） 通过将体积的培养上清液加热至至少轮状病毒失活的温度而产生。 在一些实施方案中，一旦将整个体积加热至至少轮状病毒灭活的温度，轮状病毒（例如牛轮状病毒）就被灭活。 在一些实施方案中，将细胞培养上清液的温度保持适当的时间，其可以使用本文所述的任何测试来确定。 然后可以从培养物上清液中分离灭活的轮状病毒（例如牛轮状病毒）。