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    METHODS FOR PREPARING INACTIVATED ROTAVIRUS
    3.
    发明公开
    METHODS FOR PREPARING INACTIVATED ROTAVIRUS 审中-公开
    VERFAHREN ZUR HERSTELLUNG VON INAKTIVIERTEM ROTAVIRUS

    公开(公告)号：EP3021867A1

    公开(公告)日：2016-05-25

    申请号：EP14748051.1

    申请日：2014-07-18

    Applicant: Novartis Tiergesundheit AG

    Inventor： DEKKER, Brent, E. ,  HERBERT, John, M. ,  REIMNITZ, Michael, J.

    IPC: A61K39/12 ,  C12N7/00

    CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K39/15 ,  A61K2039/5252 ,  A61K2039/55566 ,  C12N2720/12321 ,  C12N2720/12332 ,  C12N2720/12334 ,  C12N2720/12361

    Abstract: Disclosed are methods for production of inactivated rotavirus directly from cell culture supernatants containing active or infectious rotavirus (e.g., bovine rotavirus), without prior isolation or purification of the rotavirus from the cell culture supernatants. In some embodiments, inactivated rotavirus (e.g., bovine rotavirus) is produced by heating a volume of culture supernatant to at least a temperature at which the rotavirus is inactivated. In some embodiments, the rotavirus (e.g., bovine rotavirus) is inactivated once the entire volume is heated to at least a temperature at which the rotavirus is inactivated. In some embodiments, the temperature of the cell culture supernatant is maintained for a suitable amount of time, which may be determined using any of the tests described herein. Inactivated rotavirus (e.g., bovine rotavirus) may then be isolated from the culture supernatant.

    Abstract translation: 公开了直接从含有活性或感染性轮状病毒（例如牛轮状病毒）的细胞培养上清液中生产灭活轮状病毒的方法，没有事先从细胞培养物上清液中分离或纯化轮状病毒。在一些实施方案中，灭活轮状病毒（例如牛轮状病毒） 通过将体积的培养上清液加热至至少轮状病毒失活的温度而产生。 在一些实施方案中，一旦将整个体积加热至至少轮状病毒灭活的温度，轮状病毒（例如牛轮状病毒）就被灭活。 在一些实施方案中，将细胞培养上清液的温度保持适当的时间，其可以使用本文所述的任何测试来确定。 然后可以从培养物上清液中分离灭活的轮状病毒（例如牛轮状病毒）。

    NEW COMPOUNDS
    7.
    发明公开
    NEW COMPOUNDS 审中-公开
    新化合物

    公开(公告)号：EP3122731A1

    公开(公告)日：2017-02-01

    申请号：EP15713431.3

    申请日：2015-03-25

    Applicant: Novartis Tiergesundheit AG

    Inventor： GAUVRY, Noelle ,  TAHTAOUI, Chouaib ,  FURET, Pascal ,  DUCRAY, Pierre

    IPC: C07D239/46 ,  C07D471/04 ,  C07D471/14 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04 ,  A61K31/44 ,  A61K31/50 ,  A61K31/505 ,  A61K31/52

    CPC classification number: C07D471/14 ,  C07D239/42 ,  C07D239/46 ,  C07D239/48 ,  C07D471/04 ,  C07D473/34 ,  C07D487/04 ,  C07D495/04

    Abstract: The invention relates to a compound of formula wherein the variables have the meaning as indicated in the claims; in free form and in salt form; and optionally the enantiomers and geometrical isomers thereof. The compounds of formula (I) are useful as therapeutic agent for organ transplants, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, Type I diabetes and complications from diabetes, cancer, asthma, atopic dermatitis, autoimmune thyroid disorders, ulcerative colitis, inflammatory bowel diseases, Crohn's disease, Alzheimer's disease, leukemia, osteoarthritis, control of pruritus, chronic respiratory disease or keratoconjunctivitis in mammals.

    Abstract translation: 本发明涉及式（I）化合物，其中各变量具有权利要求中所述的含义; 游离形式和盐形式; 和任选的其对映体和几何异构体。 式（I）化合物可用作器官移植治疗剂，狼疮，多发性硬化症，类风湿性关节炎，银屑病，I型糖尿病和糖尿病并发症，癌症，哮喘，特应性皮炎，自身免疫性甲状腺疾病，溃疡性结肠炎，炎性肠 疾病，克罗恩病，阿尔茨海默氏病，白血病，骨关节炎，控制瘙痒症，慢性呼吸系统疾病或角膜结膜炎。

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