公开(公告)号：EP2227237A1

公开(公告)日：2010-09-15

申请号：EP08853658.6

申请日：2008-11-27

申请人： Hadasit Medical Research Services & Development Ltd. ,  Ben-gurion University Of The Negev Research And Development Authority

发明人： ILAN, Yaron ,  LALAZAR, Gadi ,  SHTEYER, Eyal ,  BEN-YAAKOV, Ami ,  COHEN, Smadar ,  ELKAYAM, Tsiona

IPC分类号： A61K31/734 ,  A61K31/738 ,  A61L27/20 ,  A61L31/04 ,  A61P1/16

CPC分类号： A61K31/738 ,  A61K31/734 ,  A61L27/20 ,  A61L31/042 ,  A61P1/16 ,  C08L5/04

摘要： The present invention relates to methods for the treatment of hepatic disorders in a subject in need thereof. More specifically, the methods of the invention are based on the administration, preferably, systemic administration, of a therapeutically effective amount of at least one biocompatible alginate biomaterial, any modification thereof and any combination thereof. The invention further provides methods for sustaining serum albumin levels, and/or reducing serum AST and ALT, in subjects suffering from hepatic disorder. Still further, the invention provides methods for reducing apoptosis and inducing cell proliferation in a damaged liver tissue of a subject suffering of hepatic disorder, using the alginate biomaterial described by the invention.

摘要翻译： 本发明涉及在有需要的受试者中治疗肝脏疾病的方法。 更具体地，本发明的方法基于治疗有效量的至少一种生物相容性藻酸盐生物材料，其任何修饰以及它们的任何组合，优选全身施用。 本发明还提供了在患有肝脏疾病的受试者中维持血清白蛋白水平和/或降低血清AST和ALT的方法。 此外，本发明提供了使用本发明描述的藻酸盐生物材料减少患有肝脏疾病的受试者的损伤的肝组织中细胞凋亡和诱导细胞增殖的方法。

公开(公告)号：EP2211878A2

公开(公告)日：2010-08-04

申请号：EP08852340.2

申请日：2008-11-18

申请人： Ben Gurion University of the Negev Research And Development Authority

发明人： VAGO, Razi

IPC分类号： A61K35/56 ,  A61P19/08 ,  A61P19/10 ,  A61P35/00 ,  A61P17/00

CPC分类号： A61L27/3604 ,  A61K35/28 ,  A61K35/614 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3687 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/102 ,  A61L2300/412 ,  A61L2430/02 ,  A61L2430/06 ,  A61L2430/40

摘要： This invention is directed to coral scaffolds seeded with precursor cells in culture in the presence of a chelator and uses thereof in inducing or enhancing bone and/or cartilage formation in a subject, and kits related thereto. This invention is also directed to use of cadherin-upregulating coral for treating cancer or inhibiting cancer progression. This invention is also directed to use of aragonite or calcite-producing species for in vivo calcium release, and its application to the treatment of skin diseases, disorders or conditions.

公开(公告)号：EP2083919A1

公开(公告)日：2009-08-05

申请号：EP07827170.7

申请日：2007-10-07

申请人： Ben-Gurion University of The Negev Research and Development Authority

发明人： SHANI, Gad

IPC分类号： A61N5/10

CPC分类号： A61N5/1001 ,  A61N2005/1019

摘要： A capsule for high dose rate brachytherapy, wherein the capsule comprises within its interior space thulium-170, and further comprises at least one layer of a radiation emission modifying metal (e.g. gold), wherein said layer is provided either internally within the capsule or on the outer surface thereof.

公开(公告)号：EP2029060A1

公开(公告)日：2009-03-04

申请号：EP07736479.2

申请日：2007-06-19

申请人： Ben-Gurion University Of The Negev Research And Development Authority

发明人： RAPAPORT, Hanna

IPC分类号： A61F2/46 ,  B01J13/16 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00

CPC分类号： C07K7/08 ,  A61F2002/2817 ,  A61K9/0024 ,  A61K9/06 ,  A61K38/08 ,  A61K38/10 ,  A61K45/06 ,  A61K47/02 ,  A61K47/36 ,  A61L27/227 ,  A61L27/52 ,  C07K7/06 ,  C07K14/00 ,  C07K14/4702 ,  C07K14/51 ,  C07K2319/09

摘要： The present invention relates in general to the field of tissue engineering and more specifically to amphiphilic peptides and peptide matrices thereof useful in vitro and in situ biomineralization and inducing bone repair. The present invention provides peptides, which are useful in hydrogels and other pharmaceutical compositions, and methods and kits of use for bone repair and promotion of biomineralization. Certain hydrogels according to the invention comprise cells within or adhered to the peptide matrix.

摘要翻译： 本发明一般涉及组织工程领域，更具体地涉及其在体外和原位生物矿化和诱导骨修复中有用的两亲肽和肽基质。 本发明提供了可用于水凝胶和其它药物组合物的肽，以及用于骨修复和促进生物矿化的方法和试剂盒。 根据本发明的某些水凝胶包含在肽基质内或附着于肽基质上的细胞。

公开(公告)号：EP1626710B1

公开(公告)日：2008-10-01

申请号：EP04735084.8

申请日：2004-05-27

申请人： YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM ,  Ben Gurion University Of The Negev Research And Development Authority

发明人： BIALER, Meir ,  YAGEN, Boris ,  BELMAKER, Haim ,  AGAM, Galila ,  SHALTIEL, Galit

IPC分类号： A61K31/16 ,  A61P25/18

CPC分类号： A61K31/16

摘要： The invention relates to the use of 2,2,3,3 tetramethylcyclopropane carboxylic acid derivative compounds for the preparation of a medicament for treating a psychiatric disorder preferably a bipolar disorder. The invention additionally relates to the use of the compounds for the preparation of an inhibitor of MIP synthase and to a pharmaceutical composition comprising the compounds for treating a psychiatric disorder. A method for treating a psychiatric disorder preferably a bipolar disorder and a method for inhibiting an enzyme having MIP synthase activity is provided.

公开(公告)号：EP1957349A1

公开(公告)日：2008-08-20

申请号：EP06809884.7

申请日：2006-11-20

申请人： Ariel-University Research And Development Company ,  Ben Gurion University of the Negev Research and Development Authority

发明人： SHRAGA, Shoval ,  SHAPIRO, Amir

IPC分类号： B62D55/065 ,  B62D59/04

CPC分类号： B62D55/0655 ,  B25J5/005 ,  B62D59/04

摘要： The invention is an autonomous dual tracked mobile (10) robot system comprising two or more tracked driving units (12x) configured to travel in tandem and a separate mechanical linkage (16), which joins each of the mobile units to the unit immediately preceding and following it, and enables efficient power transmission between the two driving units. Each of the mechanical linkages comprises one connecting bar (14) and three revolute joints (18y) located on each of the adjacent units and a connecting beam that connects the connecting bar on one of the units with the connecting bar on the adjacent unit.

公开(公告)号：EP1934348A1

公开(公告)日：2008-06-25

申请号：EP06796164.9

申请日：2006-10-15

申请人： Ben-Gurion University Of The Negev Research And Development Authority

发明人： SHOSHAN-BARMATZ, Varda ,  ABU-HAMAD, Salah

IPC分类号： C12N15/11 ,  A61K31/713

CPC分类号： C12N15/1138 ,  A61K31/713 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/53

摘要： The present invention relates generally to the down regulation of mitochondrial protein, voltage-dependent anion channel (VDAC1), expression by RNAi or antisense therapy. In particular, the present invention is directed to VDAC1 silencing molecules useful in regulating cell proliferation and to pharmaceutical compositions comprising same useful in the treatment of diseases associated with aberrant cell proliferation.

公开(公告)号：EP1893022A2

公开(公告)日：2008-03-05

申请号：EP06745172.4

申请日：2006-06-22

申请人： Ben Gurion University of the Negev Research and Development Authority Ltd.

发明人： WIESMAN, Zeev

IPC分类号： A01N45/00

CPC分类号： C07J71/00

摘要： The invention relates to stable preparations of saponin nanovesicles, which can encapsulate active biological or chemical materials such as drugs, pesticides, vitamins, minerals and nutrients, and protect them. The preparations can be used, for example, in agricultural, pesticidal, dermatological and cosmetic compositions. The saponins per se can further be used as adjuvants for irrigation water. The invention further relates to novel saponins extracted from Balanites aegyptiaca.

摘要翻译： 本发明涉及皂素纳米囊泡的稳定制备，其可以包封药物，农药，维生素，矿物质和营养素等活性生物或化学物质并保护它们。 该制剂可以用于例如农业，农药，皮肤病学和化妆品组合物。 皂苷本身可以进一步用作灌溉用水的佐剂。 本发明进一步涉及从埃及斑叶土中提取的新皂苷。

公开(公告)号：EP1732493A2

公开(公告)日：2006-12-20

申请号：EP05718942.5

申请日：2005-04-03

申请人： Ben Gurion University Of The Negev Research And Development Authority ,  MOR-RESEARCH APPLICATIONS LTD.

发明人： GURMAN, Gabriel ,  TEJMAN-YARDEN, Noa ,  TABRIKIAN, Joseph ,  WEIZMAN, Lior ,  COHEN, Arnon

IPC分类号： A61H1/00

CPC分类号： A61B7/003

摘要： A method and a device for the acoustic detection of a one lung intubation situation in a human subject are disclosed. According to some embodiments, the disclosed method includes computing an autoregressive moving average (ARMA) or an autoregressive function of electrical signals received from acoustic detectors placed at different locations on the body of the subject. Appropriate locations for acoustic detectors include the back region and the chest region. The disclosed method and apparatus are insensitive to uncancelled, random background noise with a loudness associated with an operating room or intensive care ward. The disclosed device is configurable so that the relative occurrence rate of missed detections or false negatives and false positive alarms can be modified. In one exemplary embodiment, the device is adapted such that at most 9% of identifications are false positive identifications, and at most 2% of identifications are false negative identifications.

公开(公告)号：EP1468101B1

公开(公告)日：2006-11-22

申请号：EP03706865.7

申请日：2003-01-23

申请人： BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY

发明人： CHIPMAN, David, M. ,  BARAK, Ze'ev ,  ENGEL, Stanislav ,  VYAZMENSKY, Maria

IPC分类号： C12P7/26 ,  C12P7/24

CPC分类号： C12P7/24 ,  C12P7/26

摘要： A biotransformation process for preparing chiral aromatic −hydroxy ketones in high yields is described, using 2−hydroxy−3−oxoacid synthase, such as AHAS or TSAS. Optionally substituted arylaldehydes and −oxoacids react in this process to provide pure enantiomers, useful as synthons in the production of various drugs, an example being ( R )−phenylacetyl carbinol.