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    COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF
    72.
    发明公开
    COMPOUNDS HAVING PEPTIDES CONJUGATED TO BONE TARGETING MOIETIES AND METHODS OF MAKING AND USING THEREOF 审中-公开
    连接，骨TARGET收缩单位结合肽和方法进行生产及其用途

    公开(公告)号：EP2488208A4

    公开(公告)日：2015-07-01

    申请号：EP10823111

    申请日：2010-10-12

    申请人： UNIV ALBERTA

    发明人： DOSCHAK MICHAEL R ,  KRISHNA BHANDARI HARI

    IPC分类号： A61K47/48 ,  A61K38/23 ,  A61P19/08

    CPC分类号： A61K47/48 ,  A61K38/23 ,  A61K47/50 ,  A61K47/548

    摘要： Described herein are compositions having a peptide sequence that includes at least one bone targeting moiety, wherein the bone targeting moiety is bonded to the peptide sequence by a linker, wherein the peptide sequence is calcitonin, and wherein the composition is neutral or a pharmaceutically acceptable salt or ester thereof. In one aspect, calcitonin inhibits or slows osteoclast mediated resorptive bone loss. The compounds described herein can be used in a number of therapeutic applications including treating or preventing conditions associated with bone loss, which include, but are not limited to, osteoporosis, Paget's disease, osteolytic tumors, Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Osteoarthritis, osteopenia, and hypercalcemia. Also described herein are the methods of making these compositions that prevent or treat conditions associated with bone loss and methods of preventing bone fractures.

    摘要翻译： 描述中是具有肽序列的组合物确实包括至少一个骨靶向部分，worin骨靶向部分是由左结合到肽序列，worin肽序列是降钙素和worin所述组合物是中性或药学上可接受的盐 或酯。 在一个方面，降钙素抑制或减缓破骨细胞介导的骨吸收损失。 中所述的化合物可以以多种治疗应用，包括治疗或预防与骨损失，这包括相关联的条件下使用，但不限于，骨质疏松症，佩吉特氏病，溶骨性肿瘤，类风湿关节炎，银屑病关节炎，强直性脊柱炎，骨关节炎 ，骨质疏松和高钙血症。 如此描述的是使合成的组合物并预防或治疗与骨损失和预防骨折的方法相关条件的方法。

    METHOD AND SYSTEM FOR ABO ANTIBODY DETECTION AND CHARACTERIZATION
    73.
    发明公开
    METHOD AND SYSTEM FOR ABO ANTIBODY DETECTION AND CHARACTERIZATION 审中-公开
    方法和系统进行检测和ABO血型抗体的表征

    公开(公告)号：EP2751574A4

    公开(公告)日：2015-02-18

    申请号：EP12828485

    申请日：2012-08-30

    申请人： UNIV ALBERTA

    发明人： LOWARY TODD LAMBERT ,  CAIRO CHRISTOPHER WARREN ,  WEST LORI JEANNE ,  BURIAK JILLIAN MARY ,  MELONCELLI PETER JOHN ,  JEYAKANTHAN MYLVAGANAM ,  SLANEY ANNE MARGARET

    IPC分类号： G01N33/80 ,  C40B30/04 ,  C40B40/12 ,  G01N33/564

    CPC分类号： G01N33/6854 ,  G01N33/66 ,  G01N33/80 ,  G01N2400/00

    摘要： The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO-incompatible and ABO-compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo-blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo-blood subgroup, the determined antibody profile is compared to known ABO histo-blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject. Profiles can be established by applying a sample to an array of surface-bound ABO antigens selected from the group of type I to type VI antigens of each blood group A, B or H.

    PARTICLE CLASSIFIER
    76.
    发明公开
    PARTICLE CLASSIFIER 审中-公开
    PARTIKELKLASSIFIZIERER

    公开(公告)号：EP2449359A4

    公开(公告)日：2014-05-21

    申请号：EP10793465

    申请日：2010-07-02

    申请人： UNIV ALBERTA

    发明人： OLFERT JASON

    IPC分类号： G01N15/00 ,  G01N15/02 ,  G01N15/06

    CPC分类号： G01N15/0255

    摘要： A new installment classifies particles by their aerodynamic size This installment produces a truly monodisperse aerosol, and can produce very narrow distributions over a wide range of sizes Particles suspended in a fluid are classified by supplying particles into suspension in a carrier flow of a fluid and providing an acceleration to the flow at an angle to the velocity of the flow to cause the particles to follow trajectories determined by the acceleration and drag on the particles caused by the fluid The particles are then classified according to their trajectories The installment has a flow channel and a source of particles to supply particles into suspension in a carrier fluid in the flow channel A drive is connected to the flow channel at an angle to the flow of fluid through the carrier flow channel, and a classification system classifies the suspended particles according to their trajectories.

    摘要翻译： 一种新的装置通过其空气动力学尺寸对颗粒进行分类。该装置产生真正的单分散气溶胶，并且可以在宽范围的尺寸范围内产生非常窄的分布悬浮在流体中的颗粒通过在流体的载体流中提供颗粒到悬浮液中进行分类，并提供 与流速成一定角度的加速度使颗粒跟随由流体引起的颗粒上的加速度和阻力确定的轨迹。然后根据颗粒的轨迹对颗粒进行分类。该装置具有流动通道和 将流体通道中的载体流体中的颗粒供给到悬浮液中的颗粒源A驱动器以与通过载体流动通道的流体流成一定角度连接到流动通道，并且分类系统根据它们分类悬浮颗粒 轨迹。

    BINDING-INDUCED HAIRPIN DETECTION SYSTEM
    77.
    发明公开
    BINDING-INDUCED HAIRPIN DETECTION SYSTEM 审中-公开
    结合诱导发针检测系统

    公开(公告)号：EP2473631A4

    公开(公告)日：2013-06-05

    申请号：EP10811062

    申请日：2010-08-30

    申请人： UNIV ALBERTA

    发明人： LE XIAOCHUN ,  ZHANG HONGQUAN ,  LI XING-FANG

    IPC分类号： C12Q1/68 ,  C40B30/04 ,  G01N33/53 ,  G01N33/542

    CPC分类号： G01N33/53 ,  C12Q1/6816 ,  G01N33/542 ,  G01N2458/10 ,  C12Q2525/301

    摘要： This application relates to a binding-induced hairpin detection system comprising: a. a first probe comprising a targeting molecule and an oligonucleotide that has a free end and an end attached to the targeting molecule; and b. a second probe comprising a targeting molecule and an oligonucleotide that has an end attached to the targeting molecule and a free end comprising a nucleotide sequence that is complementary to a nucleotide sequence at or near the free end of the oligonucleotide of the first probe; wherein upon binding of the targeting molecule to a target molecule, the free end of the oligonucleotide of the second probe hybridizes at or near the free end of the oligonucleotide of the first probe forming a hairpin stem, the non-hybridized portions of the first and second probes together with the target molecule bound thereto forming a hairpin loop, thereby providing a binding-induced hairpin.