公开(公告)号：EP2376115A4

公开(公告)日：2013-07-03

申请号：EP09831358

申请日：2009-12-11

申请人： UNIV ALBERTA

发明人： WEST LORI JEANNE ,  LOWARY TODD LAMBERT ,  BURIAK JILLIAN MARY ,  DALY BRIAN ,  JEYAKANTHAN MYLVAGANAM ,  MELONCELLI PETER JOHN ,  WRIGHT VINCENT ARTHUR ,  COOPER ANNE MARGARET

IPC分类号： A61K39/385 ,  A61K9/14 ,  A61L31/16 ,  A61P37/06

CPC分类号： A61L31/16 ,  A61K39/001 ,  A61K47/48215 ,  A61K47/48861 ,  A61K47/60 ,  A61K47/6923 ,  A61K49/0423 ,  A61K2039/55555 ,  A61K2039/6093 ,  A61K2039/627 ,  A61L2300/438 ,  A61L2300/80 ,  B82Y5/00

摘要： Described herein are methods and systems that can be used to induce immunologic tolerance to non-self antigens. The methods and systems comprise introducing a tolerogen comprising at least one immunogenic non-self antigen coupled to a carrier, wherein the immunogenic antigen can be a foreign or endogenous antigen or fragments thereof. The non-self antigen can be selected from the group consisting of carbohydrate antigens, full-length antigenic proteins, and fragments and combinations thereof, while the carrier can be selected from nanoparticles and stents. Tolerogen compositions are also provided and can be used to induce immunologic tolerance to non-self antigens. These methods, systems and compositions are particularly advantageous since they can be used to allow for the extension of the window of safety for immunologically-incompatible transplantations to patients who are growing past the age of infancy.

公开(公告)号：EP2751574A4

公开(公告)日：2015-02-18

申请号：EP12828485

申请日：2012-08-30

申请人： UNIV ALBERTA

发明人： LOWARY TODD LAMBERT ,  CAIRO CHRISTOPHER WARREN ,  WEST LORI JEANNE ,  BURIAK JILLIAN MARY ,  MELONCELLI PETER JOHN ,  JEYAKANTHAN MYLVAGANAM ,  SLANEY ANNE MARGARET

IPC分类号： G01N33/80 ,  C40B30/04 ,  C40B40/12 ,  G01N33/564

CPC分类号： G01N33/6854 ,  G01N33/66 ,  G01N33/80 ,  G01N2400/00

摘要： The present application discloses a system and method for ABO antibody detection and characterization that can provide an alternative means for assessment and management of ABO-incompatible and ABO-compatible transplants. The method and system comprises determining an anti-ABO blood group antigen subtype antibody profile of a subject using a biological sample from the subject. The method and system can be used to evaluate the suitability of a donor blood or tissue product for a recipient subject by comparing the determined anti-ABO antigen subtype antibody profile of the recipient subject with the ABO histo-blood group or ABO histo-blood subgroup of a donor blood or tissue product. In order to define the subject's ABO histo-blood subgroup, the determined antibody profile is compared to known ABO histo-blood group antigen subtype profiles and/or known anti-ABO antigen subtype antibody profiles for ABO histo-blood subgroups to identify the ABO histo-blood subgroup of the subject. Profiles can be established by applying a sample to an array of surface-bound ABO antigens selected from the group of type I to type VI antigens of each blood group A, B or H.