公开(公告)号：EP1814551A2

公开(公告)日：2007-08-08

申请号：EP05813076.6

申请日：2005-09-20

申请人： XENON PHARMACEUTICALS INC.

发明人： KAMBOJ, Rajender ,  ZHANG, Zaihui ,  FU, Jian-Min ,  SVIRIDOV, Serguei ,  CHOWDHURY, Sultan ,  KODUMURU, Vishnumurthy

IPC分类号： A61K31/501

CPC分类号： C07D401/12 ,  A61K31/501 ,  C07D237/24 ,  C07D403/12

摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I) where x, y, G, J, K, L, M, Q, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

公开(公告)号：EP1807085A2

公开(公告)日：2007-07-18

申请号：EP05815243.0

申请日：2005-09-20

申请人： XENON PHARMACEUTICALS INC.

发明人： KAMBOJ, Rajender ,  ZHANG, Zaihui ,  FU, Jian-Min ,  KODUMURU, Vishnumurthy ,  SVIRIDOV, Serguei ,  SADALAPURE, Kashinath ,  LIU, Shifeng ,  SUN, Shaoyi ,  HOU, Duanjie ,  CHAKKA, Nagasree

IPC分类号： A61K31/501 ,  A61K31/496 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P3/06 ,  A61P1/16 ,  C07D403/00

CPC分类号： A61K31/496 ,  A61K31/501

摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, V R2, R3, R4, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

公开(公告)号：EP1100895B1

公开(公告)日：2007-06-13

申请号：EP00917240.4

申请日：2000-03-15

申请人： UNIVERSITY OF BRITISH COLUMBIA ,  XENON PHARMACEUTICALS INC.

发明人： HAYDEN, Michael, R. ,  BROOKS-WILSON, Angela, R. ,  PIMSTONE, Simon, N.

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N5/10 ,  A01K67/027 ,  C12N15/00 ,  A61K38/17 ,  A61K48/00 ,  A61K38/45 ,  A61K31/00 ,  A61K31/70 ,  G01N33/68 ,  C12Q1/68 ,  C12N15/11

CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/53 ,  C07K14/70567

摘要： The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).

公开(公告)号：EP1763350A1

公开(公告)日：2007-03-21

申请号：EP04756752.4

申请日：2004-07-06

申请人： XENON PHARMACEUTICALS INC.

发明人： FU, Jian-Min ,  KODUMURU, Vishnumurthy ,  SUN, Shaoyi ,  WINTHER, Michael, D. ,  FINE, Richard, M. ,  HARVEY, Daniel, F. ,  KLEBANSKY, Boris ,  GRAY-KELLER, Mark ,  GSCHWEND, Heinz, W.

IPC分类号： A61K31/496 ,  C07D401/00 ,  A61P43/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

CPC分类号： A61K31/496

摘要： Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where m, n, p, V, R1, R2, R3, R4, R5 and R6 are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.

公开(公告)号：EP4405344A2

公开(公告)日：2024-07-31

申请号：EP22793913.9

申请日：2022-09-23

申请人： Xenon Pharmaceuticals Inc.

发明人： BURFORD, Kristen ,  LOFSTRAND, Verner ,  KIM, Jung Yun ,  CLEMENT, Helen ,  CHARIFSON, Paul ,  CLARK, Michael

IPC分类号： C07D401/12 ,  C07D405/04 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14 ,  C07D405/12 ,  A61K31/4433 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/443 ,  A61K31/506 ,  A61P25/08

CPC分类号： C07D401/12 ,  C07D405/04 ,  C07D413/14 ,  C07D405/14 ,  C07D401/14 ,  C07D405/12

公开(公告)号：EP3790548B1

公开(公告)日：2023-08-23

申请号：EP19727216.4

申请日：2019-05-10

发明人： BEATCH, Gregory N.

IPC分类号： A61K31/472 ,  A61P25/08

公开(公告)号：EP3436432B1

公开(公告)日：2021-01-27

申请号：EP17716041.3

申请日：2017-03-28

发明人： CHOWDHURY, Sultan ,  DEHNHARDT, Christoph Martin ,  FOCKEN, Thilo ,  GRIMWOOD, Michael Edward ,  HEMEON, Ivan William ,  MCKERRALL, Steven ,  SUTHERLIN, Daniel

IPC分类号： A61P25/04 ,  C07C381/10 ,  C07D401/12 ,  C07D205/04 ,  C07D211/22 ,  C07D211/42 ,  C07D213/69

公开(公告)号：EP3526205A1

公开(公告)日：2019-08-21

申请号：EP17863182.6

申请日：2017-09-26

申请人： Genentech, Inc. ,  Xenon Pharmaceuticals Inc.

发明人： SUTHERLIN, Daniel ,  MCKERRALL, Steven ,  WILSON, Michael Scott ,  LAI, Kwong Wah ,  BERGERON, Philippe ,  ZHANG, Birong ,  BEVERIDGE, Ramsay ,  LECLERC, Jean-Philippe ,  LEMIRE, Alexandre ,  ZHAO, Liang ,  STURINO, Claudio

IPC分类号： C07D285/08 ,  A61K31/427 ,  A61P19/02

公开(公告)号：EP3166939B1

公开(公告)日：2019-06-05

申请号：EP15744417.5

申请日：2015-07-07

申请人： Genentech, Inc. ,  Xenon Pharmaceuticals Inc.

发明人： ANDREZ, Jean-Christophe ,  BERGERON, Philippe ,  BICHLER, Paul Robert ,  CHOWDHURY, Sultan ,  DEHNHARDT, Christoph Martin ,  FOCKEN, Thilo ,  GONG, Wei ,  GRIMWOOD, Michael Edward ,  HASAN, Abid ,  HEMEON, Ivan William ,  JIA, Qi ,  SAFINA, Brian ,  SUN, Shaoyi ,  WILSON, Michael Scott ,  ZENOVA, Alla Yurevna

IPC分类号： C07D403/12 ,  C07D413/14 ,  C07D221/22 ,  C07D401/10 ,  C07D401/12 ,  C07D403/10 ,  C07D413/12 ,  C07C235/52 ,  C07D205/04 ,  C07D207/16 ,  C07D277/06 ,  C07D209/02 ,  C07D305/08 ,  A61K31/401 ,  A61P17/04

公开(公告)号：EP2838902B1

公开(公告)日：2018-12-05

申请号：EP13710961.7

申请日：2013-03-11

申请人： Xenon Pharmaceuticals Inc.

发明人： SUN, Shaoyi ,  FU, Jianmin ,  CHOWDHURY, Sultan ,  HEMEON, Ivan, William ,  GRIMWOOD, Michael, Edward ,  MANSOUR, Tarek, Suhayl

IPC分类号： C07D491/20 ,  A61K31/407 ,  A61P25/00

CPC分类号： C07D491/20 ,  C07D209/34 ,  C07D405/04 ,  C07D405/06 ,  C07D405/10 ,  C07D405/14 ,  C07D491/107

摘要： This invention is directed to asymmetric syntheses of certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.