公开(公告)号：EP4452997A1

公开(公告)日：2024-10-30

申请号：EP22912469.8

申请日：2022-12-22

申请人： Wisconsin Alumni Research Foundation

发明人： SUSSMAN, Michael ,  MINKOFF, Benjamin ,  WOLFER, Jamison ,  BURCH, Heather

IPC分类号： C07K1/107 ,  C07K1/13 ,  C07D249/04 ,  C01B21/08 ,  C07C2/38 ,  C07D499/40 ,  A61K47/68

公开(公告)号：EP4452410A1

公开(公告)日：2024-10-30

申请号：EP22850890.9

申请日：2022-12-21

申请人： Children's Hospital Medical Center

发明人： JODELE, Sonata ,  MIZUNO, Kana ,  VINKS, Alexander, A.

IPC分类号： A61P7/00 ,  A61P37/06 ,  C07K16/18 ,  A61K39/00

公开(公告)号：EP4452320A1

公开(公告)日：2024-10-30

申请号：EP22854694.1

申请日：2022-12-21

申请人： GENENTECH, INC.

发明人： SHIEH, Ian Chung-ti ,  WOYS, Ann Marie ,  TSCHUDI, Katherine Laura ,  SUHLING, Robyn Mariah ,  SANE, Rucha Sudhakar ,  CHAN, Hui Min Phyllis ,  WEN, Xiaohui ,  ROONEY, Isabelle Anne

IPC分类号： A61K47/00 ,  C07K16/28 ,  A61P35/00

公开(公告)号：EP4452314A1

公开(公告)日：2024-10-30

申请号：EP22839882.2

申请日：2022-12-21

申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED

发明人： HYDE, Stephen ,  MIAH, Kamran ,  GILL, Deborah ,  DY, Yue

IPC分类号： A61K39/215 ,  C07K14/165

公开(公告)号：EP4452298A2

公开(公告)日：2024-10-30

申请号：EP22912464.9

申请日：2022-12-22

申请人： Memorial Sloan-Kettering Cancer Center ,  Sloan-Kettering Institute for Cancer Research ,  Memorial Hospital for Cancer and Allied Diseases

发明人： ADUSUMILLI, Prasad, S. ,  SADELAIN, Michel ,  CHEN, Nan ,  CHINTALA, Navin ,  PERICA, Karlo

IPC分类号： A61K38/17 ,  A61P37/02 ,  A61K39/395 ,  C07K19/00 ,  A61P35/00

公开(公告)号：EP4452295A1

公开(公告)日：2024-10-30

申请号：EP22912102.5

申请日：2022-12-20

申请人： Virenc AB

发明人： KHALAF, Hazem ,  BENGTSSON, Torbjörn ,  HINKULA, Jorma ,  MELIK, Wessam ,  SELEGÅRD, Robert ,  AILI, Daniel

IPC分类号： A61K38/16 ,  A61P31/12 ,  C07K14/335

公开(公告)号：EP4452294A1

公开(公告)日：2024-10-30

申请号：EP22826571.6

申请日：2023-04-21

申请人： THE UNIVERSITY OF SOUTHERN CALIFORNIA

发明人： SELSTED, Michael E. ,  TRAN, Dat Q. ,  KRISHINAPPA, Jagadish

IPC分类号： A61K38/12 ,  C07K16/28 ,  A61P35/00

公开(公告)号：EP4451863A1

公开(公告)日：2024-10-30

申请号：EP22851345.3

申请日：2022-12-16

申请人： REGENERON PHARMACEUTICALS, INC.

发明人： BRYDGES, Susannah ,  KYRATSOUS, Christos ,  BAUM, Alina

IPC分类号： A01K67/027 ,  C07K14/705 ,  C12N9/48

公开(公告)号：EP4428147A3

公开(公告)日：2024-10-30

申请号：EP24177118.7

申请日：2018-11-09

申请人： Keros Therapeutics, Inc.

发明人： LACHEY, Jennifer ,  SEEHRA, Jasbir S.

IPC分类号： A61K38/18 ,  A61K38/38 ,  A61P19/00 ,  A61P19/08 ,  A61P19/10 ,  C07K14/71

摘要： The invention features polypeptides that include an extracellular ActRlla variant. In some embodiments, a polypeptide of the invention includes an extracellular ActRlla variant fused to an Fc domain monomer or moiety. The invention also features pharmaceutical compositions and methods of using the polypeptides to treat diseases and conditions involving bone damage, e.g., primary osteoporosis, secondary osteoporosis, osteopenia, osteopetrosis, fracture, bone cancer or cancer metastasis-related bone loss, Paget's disease, renal osteodystrophy, treatment-related bone loss, diet-related bone loss, bone loss associated with the treatment of obesity, low gravity-related bone loss, or immobility-related bone loss.

公开(公告)号：EP4414704A3

公开(公告)日：2024-10-30

申请号：EP24166021.6

申请日：2018-06-08

申请人： The Brigham and Women's Hospital, Inc.

发明人： HAJ DEZFULIAN, Mohammad ,  ELLEDGE, Stephen ,  KULA, Tomasz

IPC分类号： C07K14/74 ,  C12N5/10 ,  C12N15/10 ,  C12Q1/02 ,  C12Q1/68 ,  C40B20/04 ,  C12N5/0783 ,  C12N5/09 ,  C40B40/02 ,  G01N33/50 ,  A61K39/00

摘要： Described herein, in one aspect, are antigen presenting cells (APCs) comprising an exogenous nucleic acid encoding one or more candidate antigens, wherein the one or more candidate antigens are expressed and presented with MHC class I or MC class II molecules; a molecular reporter of Granzyme B (GzB) activity; and c) an exogenous inhibitor of caspase-activated deoxyribonuclease (CAD)-mediated DNA degradation, a CAD knockout, or a caspase knockout (e.g., caspase 3 knockout). Described herein, in another aspect, is a system for detection of recognized antigen presentation by an antigen presenting cell to a cytotoxic lymphocyte or NK cell.