公开(公告)号：EP2231176A2

公开(公告)日：2010-09-29

申请号：EP08860890.6

申请日：2008-12-15

申请人： The Brigham and Women's Hospital, Inc. ,  Immune Disease Institute Inc. ,  The General Hospital Corporation

发明人： ELLEDGE, Stephen ,  LIEBERMAN, Judy ,  BRASS, Abraham L.

IPC分类号： A61K38/08 ,  A61P31/18

CPC分类号： C12N15/111 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2320/12 ,  C12N2330/51

摘要： Disclosed herein are methods for treating and/or preventing HIV infection in a cell. The methods involve downmodulating one or more of the HIV-dependency factors (HDFs) disclosed herein to thereby treat and/or prevent HIV infection in the cell. Downmodulating the HDFs can be by contacting the cell with an agent that downmodulates the HDF. Also disclosed herein are methods for treating and/or preventing HIV infection in a subject comprising downmodulating one or more of the HIV-dependency factors (HDFs), disclosed herein, to thereby treat and/or prevent HIV infection in the subject. The method may further comprise selecting a subject diagnosed with or at risk for HIV infection, prior to downmodulating. Downmodulating the HDFs may comprise administering an agent that downmodulates the HDF to the subject such that the agent contacts HIV host cells of the subject. The agent may inhibit HDF gene expression, protein synthesis, HDF function or HDF activity, or combinations thereof.

公开(公告)号：EP4414704A3

公开(公告)日：2024-10-30

申请号：EP24166021.6

申请日：2018-06-08

申请人： The Brigham and Women's Hospital, Inc.

发明人： HAJ DEZFULIAN, Mohammad ,  ELLEDGE, Stephen ,  KULA, Tomasz

IPC分类号： C07K14/74 ,  C12N5/10 ,  C12N15/10 ,  C12Q1/02 ,  C12Q1/68 ,  C40B20/04 ,  C12N5/0783 ,  C12N5/09 ,  C40B40/02 ,  G01N33/50 ,  A61K39/00

摘要： Described herein, in one aspect, are antigen presenting cells (APCs) comprising an exogenous nucleic acid encoding one or more candidate antigens, wherein the one or more candidate antigens are expressed and presented with MHC class I or MC class II molecules; a molecular reporter of Granzyme B (GzB) activity; and c) an exogenous inhibitor of caspase-activated deoxyribonuclease (CAD)-mediated DNA degradation, a CAD knockout, or a caspase knockout (e.g., caspase 3 knockout). Described herein, in another aspect, is a system for detection of recognized antigen presentation by an antigen presenting cell to a cytotoxic lymphocyte or NK cell.

公开(公告)号：EP4414704A2

公开(公告)日：2024-08-14

申请号：EP24166021.6

申请日：2018-06-08

申请人： The Brigham and Women's Hospital, Inc.

发明人： HAJ DEZFULIAN, Mohammad ,  ELLEDGE, Stephen ,  KULA, Tomasz

IPC分类号： G01N33/50

CPC分类号： C12N15/1037 ,  C40B20/04 ,  G01N33/5047 ,  G01N2333/9643620130101 ,  C40B40/02 ,  C12N5/0693 ,  C12N2529/1020130101 ,  C12N5/0636 ,  A61K39/4611 ,  A61K39/4632 ,  A61K39/464838

摘要： Described herein, in one aspect, are antigen presenting cells (APCs) comprising an exogenous nucleic acid encoding one or more candidate antigens, wherein the one or more candidate antigens are expressed and presented with MHC class I or MC class II molecules; a molecular reporter of Granzyme B (GzB) activity; and c) an exogenous inhibitor of caspase-activated deoxyribonuclease (CAD)-mediated DNA degradation, a CAD knockout, or a caspase knockout (e.g., caspase 3 knockout). Described herein, in another aspect, is a system for detection of recognized antigen presentation by an antigen presenting cell to a cytotoxic lymphocyte or NK cell.

公开(公告)号：EP3634992A1

公开(公告)日：2020-04-15

申请号：EP18812782.3

申请日：2018-06-08

申请人： The Brigham And Women's Hospital Inc.

发明人： HAJ DEZFULIAN, Mohammad ,  ELLEDGE, Stephen ,  KULA, Tomasz

IPC分类号： C07K14/74 ,  C12N5/10 ,  C12N15/10 ,  C12Q1/02 ,  C12Q1/68 ,  C40B20/04