摘要:
Methods of treatment or prevention of a cancerous or pre-cancerous condition, of slowing or preventing growth of a cancerous condition, of stimulating a cell-mediated immune response, stimulating a Th1 helper T cell response against a pathogen in a mammal and of treating or preventing inflammatory diseases or disorders that involve administration of N-methyl pyrrolidone (NMP) or a physiologically acceptable salt, solvate, tautomer or prodrug thereof are provided. Also provided are formulations of an active agent.
摘要:
The invention relates to novel pyrazolyl-derivatives of general formula (I). The invention also relates to methods for producing the compounds of formula (I). The compounds according to the invention are particularly suitable for controlling insects and arachnids in agricultural applications and for controlling ectoparasites in veterinary medicine.
摘要:
The present disclosure relates to methods of preventing or treating parasite infection in a plurality of fish in need thereof, comprising administering to the fish an effective amount of a medicated fish feed. The medicated fish feed comprises fish feed granules or pellets coated with a composition comprising a neonicotinoid such as imidacloprid and a carrier having a high apparent digestibility coefficient such as a processed/cooked corn protein concentrate.
摘要:
The present invention provides: a bipyridine compound that exhibits an excellent control effect against noxious arthropods and is represented by formula (1) [In the formula, L represents a single bond etc., R 1 represents a C1-C10 chain hydrocarbon group etc. that has one or more halogen atoms, R 2 represents a C1-C6 alkyl group that may have one or more halogen atoms, R 3 represents a C1-C6 chain hydrocarbon group etc. that may have one or more substituent groups selected from group B, q represents 0, 1, 2, or 3, R 6 represents a C1-C6 alkyl group etc. that may have one or more halogen atoms, p represents 0, 1, 2, or 3, n represents 0, 1, or 2, and m represents 0, 1, or 2.]; an N-oxide compound of said bipyridine compound; and a composition that contains said compound.
摘要:
The compound 3,3,3-trifluoro-N-((1,4-trans)-4-((3-((S)-2-methylmorpholino)-1H- pyrazolo[3,4-d]pyrimidin-6-yl)amino)cyclohexyl)propane-1-sulfonamidehaving the Formula (I) or a salt thereof, its opposite enantiomer, compositions comprising the compound and its use in the treatment or prevention of leishmaniasis, particularly visceral leishmaniasis.
摘要:
The invention encompasses the novel class of compounds represented by the Formula (I) below, which are inhibitors of the TC-PTP enzyme. The invention also encompasses pharmaceutical compositions which include the compounds shown above and methods of treating or preventing TC-PTP mediated diseases, including cancer, via their use in the activation of antigen-presenting cells, like dendritic cells, for applications in the immunotherapeutic treatment of diseases.
摘要:
The present invention relates to novel azolobenzazine compounds of the formula I and the N- oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof wherein C1 is C or CH C2 is C or CH A1 is N or C A2 is N, C(R2), N(R3), O, S or C(R4,R5); and A3 is N, O, S, N(R6), C(R7) or C(R8,R9); A4 is N or C(R); A5 is N or C(R); A6 is N or C(R); where one or two non-adjacent bonds in the 5-membered ring formed by C1, C2, A1, A2 and A3 are double bonds, while the others are single bonds, provided that the bond between A1 and A2 or the bond between A1 and C1 or the bond between A2 and A3 or the bond between C1 and C2 or the bond between A3 and C2 is a double bond further provided that at least one of A1, A2 and A3 is N, N(R3) or N(R6), and where Ar, R, R1, R2, R3, R4,R5, R6, R7, R8 and R9 are as defined in the claims. The compounds of formula (I), as well as the N-oxides, stereoisomers, tautomers and agriculturally or veterinarily acceptable salts thereof, are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
摘要:
This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.
摘要:
New compositions and methods are provided for controlling a parasitic infection in a horse through administration of an effective amount of D. flagrans. In certain aspects, multiple, distinct strains of D. flagrans are administered. In additional aspects, the amount and treatment regimen of D. flagrans administered to a horse is based on one or more pre-identified characteristics of the horse, is combined with additional therapeutic agents for more comprehensive parasite control, or is accomplished via custom made, pre-measured daily dose packages.