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公开(公告)号：EP3734539A1
公开(公告)日：2020-11-04
申请号：EP18895071.1
申请日：2018-07-11
发明人： KIM, Do Yeong , KIM, Do Won
摘要： The present embodiment provides an assessment education device and method for a debt management capability, the device and method generate an event that causes psychological confusion in rounds on a debt management assessment scenario and provide education contents when a user who is in a psychologically confused state repays the debt, such that individuals attempting to repay the debt can be induced to make rational decisions in a situation in which various debts are mixed and the debt management capability of individuals can be improved.
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公开(公告)号：EP3719031A2
公开(公告)日：2020-10-07
申请号：EP18882347.0
申请日：2018-11-29
发明人： YOO, Tae Hyeon , PARK, Jisoo , LEE, Yumi
摘要： The present invention relates to an antibody conjugating peptide including an amino acid having a photoreactive functional group, a physiologically active substance modified with the conjugating peptide, and an antibody conjugate having an antibody linked to the physiologically active substance. When the physiologically active substance modified with the conjugating peptide according to the present invention is linked to the antibody, the conjugation efficiency between the antibody and the physiologically active substance is remarkably improved as compared to that of the conventional art, and thus, the drug may be firmly bound without impairing the specificity of the antibody, thereby making it possible to accelerate commercialization of the antibody conjugate.
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83.发明公开
公开(公告)号：EP3680250A1
公开(公告)日：2020-07-15
申请号：EP18854495.1
申请日：2018-09-07
发明人： KIM, Yong Sung , KIM, Ye Jin , JUNG, Keunok , KIM, Jeong-Ah
摘要： The present invention relates to a composition for inhibiting regulatory T cell immunosuppression, containing a fusion protein comprising a peptide that binds specifically to neuropilin 1 (NRP1). The fusion protein comprising the peptide that binds specifically to neuropilin 1 according to the present invention can reduce the proportion of regulatory T cells among CD4+ T cells in tumor tissue and inhibit the activity of regulatory T cells that infiltrated into tumor tissue, thereby down-regulating immunosuppression in the tumor tissue without causing systemic toxicity. Thus, the fusion protein can exhibit a high effect on tumor treatment.
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公开(公告)号：EP3636163A1
公开(公告)日：2020-04-15
申请号：EP18794619.9
申请日：2018-05-03
发明人： ROH, Tae Hoon
IPC分类号： A61B17/00
摘要： The present disclosure provides a fine surgical instrument capable of performing a joint movement and a rotational movement. The fine surgical instrument includes a rod portion (100, 100', 100") which is formed in a longitudinal direction to enter a surgery site located in a narrow space, a joint portion (200, 200', 200") which is formed on one side of the rod portion (100, 100', 100") and rotates in one direction from the one side of the rod portion (100, 100', 100"), a shaft (300) which is inserted into the rod portion (100, 100', 100"), a handle portion (400) which is coupled with the other side of the rod portion (100, 100', 100"), and a distal end portion (500) which is coupled with one end of the shaft (300) and is connected to the handle portion (400), in which the distal end portion (500) is operated along a manipulation of the handle portion (400).
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85.发明公开
公开(公告)号：EP3610869A1
公开(公告)日：2020-02-19
申请号：EP18784465.9
申请日：2018-04-10
IPC分类号： A61K31/225 , A61K36/258 , A61K36/16 , A61K31/05 , A61K36/87 , A23L33/10 , A23L33/105
摘要： The present invention relates to a pharmaceutical composition, containing sarpogrelate or a pharmaceutically acceptable salt thereof as an active ingredient, for preventing, alleviating, or treating sensorineural hearing loss. The sarporgrelate according to the present invention protects against hearing loss caused by noise through the suppression of auditory cell apoptosis and the expression increase of antioxidant enzyme in auditory cells, and thus can be advantageously used in the prevention and alleviation of sensorineural hearing loss.
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86.发明公开
公开(公告)号：EP3581175A1
公开(公告)日：2019-12-18
申请号：EP18751180.3
申请日：2018-02-08
发明人： KIM, Moon Suk , HEO, Ji Yeon
IPC分类号： A61K9/50 , A61K9/10 , A61K9/00 , A61K47/30 , A61K31/496
摘要： The present invention relates to a drug delivery formulation for treating a mental illness or a central nervous system disorder and, more particularly, to a drug delivery formulation for treating a mental illness or a central nervous system disorder, comprising a microcapsule containing a biodegradable polymer and a drug and a crosslinked hydrogel and a method for preparing the same. A drug delivery formulation for treating a mental illness or a central nervous system disorder according to the present invention can slowly release a drug at a constant rate without a burst of drug release in the early stage of drug administration to maintain a constant blood drug level over a long period of time and thus enjoys the advantage of preventing excessive initial release of drug, which is a problem with the administration of conventional psychopharmaceutical agents or antidepressants, and easily obtaining a desirable sustained release behavior by single administration without necessity for multiple administrations divided at regular time intervals. In addition, a method for preparing a drug delivery formulation according to the present invention is a process simpler than conventional methods and has the advantage of reducing time and cost in preparing a sustained-release drug delivery formulation.
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公开(公告)号：EP3508495A1
公开(公告)日：2019-07-10
申请号：EP17847030.8
申请日：2017-08-31
申请人： Korea University Research and Business Foundation , Ajou University Industry-Academic Cooperation Foundation
发明人： LEE, Kyung-Mi , LIM, Seon Ah , KIM, Yong Sung , KIM, Ye Jin
摘要： A heterodimeric Fc-fused protein and a pharmaceutical composition comprising the heterodimeric Fc-fused protein are disclosed. The heterodimeric Fc-fused protein comprises first and second Fc regions of an immunoglobulin heavy chain constant region (Fc) pair and in which IL-21 is bound to at least one of the N-terminus or the C-terminus of the first Fc region and/or the second Fc region, wherein CH3 domains of the first Fc region and the second Fc region are mutated such that the formation of a heterodimer is promoted.
When the heterodimeric Fc-fused protein according to the present invention is used, an in vivo half-life of IL-21 included in the heterodimeric Fc-fused protein may be significantly increased.-
公开(公告)号：EP2564653B1
公开(公告)日：2018-10-17
申请号：EP11775213.9
申请日：2011-04-22
发明人： OH, Seong-Keun , LEE, Min
CPC分类号： H04W74/0875
摘要： Disclosed is a method of performing random access by a User Equipment (UE) in a wireless communication system. The method includes generating at least two random access signals with their own priorities, and transmitting the at least two random access signals with their own priorities. The random access method may include transmitting at least two random access signals to at least two target communication nodes. Further, the random access method may include transmitting at least one random access signal, and selecting at least one of at least two random access response signals received in response to the at least one random access signal and performing random access control by using the selected random access response signals.
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89.发明授权
公开(公告)号：EP2895275B1
公开(公告)日：2018-09-12
申请号：EP13859375.1
申请日：2013-11-27
发明人： KIM, Jae Ho , KIM, Hyo Sop
CPC分类号： B05D3/12 , B05D7/02 , B81C1/00031 , B81C1/0038 , C09D1/00 , C09D125/06 , Y10T428/24612
摘要： Disclosed is a coating method using particle alignment, including preparing a cohesive polymer substrate having a smooth surface; and coating the smooth surface of the cohesive polymer substrate with a plurality of particles while forming recesses respectively corresponding to the particles on the smooth surface of the cohesive polymer substrate by pressing the particles to the cohesive polymer substrate, so that binding properties between the particles and the cohesive polymer substrate are enhanced.
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90.发明公开
公开(公告)号：EP3363818A1
公开(公告)日：2018-08-22
申请号：EP16855701.5
申请日：2016-10-12
发明人： KIM, Yong Sung , CHOI, Hye Ji , HA, Ji Hee
IPC分类号： C07K16/46 , C12N15/81 , A61K39/395
CPC分类号： C07K16/46 , A61K39/395 , C07K2317/10 , C07K2317/31 , C07K2317/35 , C07K2317/526 , C12N15/1037 , C12N15/81
摘要： The present disclosure relates to a method for evaluating and screening a mutant inducing the high-efficiency formation of heterodimers from a human antibody heavy chain constant region mutant pair combination library in order to increase the yield of formation of human antibody heterodimeric heavy chain constant regions, and to a heterodimeric heavy chain constant region (heterodimeric F) library thereby. In addition, the present disclosure relates to a CH3 domain mutant pair in which the formation of the heterodimeric heavy chain constant regions is preferred in the library, to a heterodimeric heavy chain constant region pair comprising the CH3 mutant pair, to a bispecific antibody, to a fusion protein, and a use thereof. The CH3 domain mutant pair according to the present disclosure forms heterodimeric heavy chain constant regions at a high yield of at least 80-90%, and also has excellent thermal stability and retains binding ability to the heavy chain constant region receptor (FcRn). The CH3 domain mutant pair, the bispecific antibody comprising the same, or the antibody constant region fusion protein of the present disclosure can be usefully applied to the treatment or prevention of diseases associated with target antigens or target proteins.
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