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81.发明公开INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 FOR USE IN THERAPEUTIC METHODS AND SCREENING METHOD RELATING THERETO 审中-公开糖原合酶激酶3对于治疗方法的抑制剂，相关联。因此筛选过程
公开(公告)号：EP2547401A1
公开(公告)日：2013-01-23
申请号：EP11708743.7
申请日：2011-03-16
IPC分类号： A61P11/00 , A61K31/404 , A61K31/519 , A61K31/4015
CPC分类号： A61K31/4015 , A61K31/404 , A61K31/4745 , A61K31/519 , A61K33/14
摘要： The present invention relates to an inhibitor of glycogen synthase kinase 3 (GSK-3) for use in a method of treating or preventing emphysema, a method of activating an emphysema cell, an activated emphysema cell obtained by this method for use in a method of treating or preventing emphysema, and a method of screening for a substance for treating or preventing emphysema.
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82.发明授权
公开(公告)号：EP2176286B1
公开(公告)日：2012-11-21
申请号：EP08785307.3
申请日：2008-08-01
IPC分类号： C07K14/435
CPC分类号： C07K14/43595 , C07K2319/01 , C07K2319/20 , G01N33/533 , G01N33/582 , Y10T436/143333
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83.发明授权KASPP (LRRK2) GENE, ITS PRODUCTION AND USE FOR THE DETECTION AND TREATMENT OF NEURODEGENERATIVE DISORDERS 有权KASPP（LRRK2）GEN，ITS检测和治疗神经退行性疾病的生产和使用
公开(公告)号：EP1802749B1
公开(公告)日：2012-08-22
申请号：EP05797320.8
申请日：2005-09-27
申请人： Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Eberhard Karls Universität Tübingen , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： MEITINGER, Thomas , STROM, Tim, Matthias , BISKUP, Saskia , UEFFING, Marius , KREMMER, Elisabeth , GLOECKNER, Christian, J. , GASSER, Thomas , LEITNER, Petra , ASMUS, Friedrich , PATENGE, Nadja , ZIMPRICH, Alexander , FARRER, Matthew, J. , KACHERGUS, Jennifer, M. , LINCOLN, Sara, J. , HULIHAN, Mary, M. , WSZOLEK, Zibigniew , UITTI, Ryan
IPC分类号： C12N9/12
CPC分类号： C12N9/1205
摘要： The present invention refers to a newly discovered gene named KASPP for Kinase Associated with Parkinsonism with Pleiomorphic Pathology or alternatively named LRRK2 for Leucine-Rich Repeat Kinase 2, its production, biochemical characterization and use for the detection and treatment of neurodegenerative disorders, such as Parkinson disease (PD) including, without limitation, sporadic PD, Alzheimer disease (AD), amyotrophic lateral sclerosis (ALS), and other synucleinopathies and/or tauopathy as well as several polymorphisms and mutations in the KASPP/LRRK2 gene segregated with PD.
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84.发明授权
公开(公告)号：EP2201116B1
公开(公告)日：2012-08-08
申请号：EP08802303.1
申请日：2008-09-17
CPC分类号： C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2320/12 , C12N2320/50
摘要： The present invention relates to a combination of DNA segments comprising: (a) a first segment comprising in 5' to 3' or 3' to 5' order: (aa) a promoter; (ab) a first DNA sequence comprising: (i) a DNA sequence giving rise upon transcription to the sense strand of an shRNA molecule; (ii) a transcriptional stop element which is flanked by a first type of recombinase recognition sequences; and (iii) a DNA sequence giving rise upon transcription to the antisense strand of an shRNA molecule; (b) a second segment comprising in 5' to 3' or 3' to 5' order: (ba) a promoter; (bb) a second DNA sequence comprising: (i) a DNA sequence giving rise upon transcription to the sense strand of an shRNA molecule; (ii) a transcriptional stop element which is flanked by a second type of recombinase recognition sequences; and (iii) a DNA sequence giving rise upon transcription to the antisense strand of an shRNA molecule; wherein (i) said first type of recombinase recognition sequences are recognized and recombined by a recombinase but not recombined with said second type of recombinase recognition sequences; (ii) said second type of recombinase recognition sequences are recognized and recombined by the recombinase of (i) but not recombined with said first type of recombinase recognition sequences; and (iii) said DNA sequence of (ab) and (bb) is expressed under the control of said promoters of (aa) and (ba) upon removal of said transcriptional stop elements of (ab) and (bb) by the activity of a recombinase, resulting in transcription of said shRNA molecule in a cell. Further, the invention relates to a genetically engineered non-human animal and a method to produce said transgenic non-human animal. Also, the invention relates to a cell genetically engineered with the DNA molecule of the invention and a method of simultaneously knocking down two genes in a cell. Furthermore, envisaged is a method of identifying a combination of two target genes as a potential drug target and the use of the DNA molecule of the invention for the preparation of a composition for gene therapy.
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85.发明公开
公开(公告)号：EP2449362A1
公开(公告)日：2012-05-09
申请号：EP09776877.4
申请日：2009-06-29
IPC分类号： G01N21/17 , A61B5/00 , A61B5/1455
CPC分类号： A61B5/0095 , A61B5/0059 , A61B5/0093 , G01N21/17 , G01N21/1702
摘要： A method of thermoacoustic imaging of an object, comprises the steps of providing thermoacoustic signals representing a mechanical wave response to a delivery of electromagnetic energy into the imaged object, reconstructing an energy deposition image representing a local energy absorption within the object based on the thermoacoustic signals, and decomposing the energy deposition image into a quantitative absorption image representing a distribution of a local absorption coefficient in the object and at least one further image component. Preferably, the energy deposition image reconstructing step comprises providing a forward model matrix of thermoacoustic signal propagation, and matrix-based acoustic inversion of the thermoacoustic signals utilizing an inverted model matrix approach. Furthermore, an imaging device is described which is adapted for conducting the thermoacoustic imaging of the object.
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公开(公告)号：EP2440651A2
公开(公告)日：2012-04-18
申请号：EP10725125.8
申请日：2010-06-10
IPC分类号： C12M1/34 , G01N27/414
CPC分类号： G01T1/02 , G01N33/48728
摘要： The present application relates to semiconductor devices, in particular to a device for monitoring a cell signal such as an electrical signal produced by living cells in response to external stimulation, optionally in real time, comprising (a) at least one discrete area comprising a high electron mobility transistor (HEMT); and (b) non-excitable cells attached to said HEMT (HEMT element) for example, fibroblasts, HEK, CHO cell lines, keratinocytes, etc. Preferably, the HEMT is an AlGaN/GaN FET. Accordingly, the device can be applied in uses and methods for monitoring a cell signal such as an electrical signal produced by living cells in response to external stimulation, optionally in real time. Likewise, the device can be applied for screening compounds that reverse, protect from and/or shield cells from external stimuli which cause damage to cells. Also, kits comprising the device are disclosed.
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公开(公告)号：EP2288413B1
公开(公告)日：2012-03-14
申请号：EP08802825.3
申请日：2008-10-08
发明人： ISSELS, Rolf
CPC分类号： A61N1/403 , A61N5/10 , A61N5/1042 , A61N7/02 , A61N2005/1061
摘要： The invention relates to a therapeutic device (1) for treatment of a patient, particularly for cancer treatment, comprising a radiation therapy apparatus (2) for applying an ionizing radiation to the patient, characterized by an integrated thermotherapeutic heating device (8) for inducing a regional hyperthermia in the patient.
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88.发明授权VORRICHTUNG UND VERFAHREN ZUR ENTNAHME EINES BODENMONOLITHEN AUS EINEM LYSIMETERGEFÄß 有权装置和方法用于去除土壤MONOLITH从蒸渗仪
公开(公告)号：EP1991851B8
公开(公告)日：2012-03-14
申请号：EP07712322.2
申请日：2007-02-26
申请人： Umwelt-Geräte-Technik GmbH , Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
IPC分类号： G01N1/04
CPC分类号： G01N1/04 , E02D1/04 , G01N15/082 , G01N2001/2873
摘要： The invention relates to a unit for removing a soil monolith from a lysimeter casing. Said unit is provided with a holding and receiving device (16) for the lysimeter casing (14) containing the soil monolith (12), and a driving device which acts on the soil monolith (12) and/or the lysimeter casing (14) for the continuous and/or gradual displacement of the soil monolith (12) out of the lysimeter casing (14). The invention also relates to a method for removing a soil monolith from a lysimeter casing. According to said method, a force is applied to the soil monolith (12) and/or the lysimeter casing (14), the soil monolith and the lysimeter casing then being displaced in relation to each other.
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公开(公告)号：EP1851320B1
公开(公告)日：2011-12-28
申请号：EP06703897.6
申请日：2006-01-24
发明人： DREXLER, Ingo , SUTTER, Gerd , GASTEIGER, Georg , ERFLE, Volker
IPC分类号： C12N15/863 , A61K39/00 , A61K39/39
CPC分类号： C12N15/86 , A61K39/00 , A61K39/39 , A61K2039/5256 , C12N2710/24143 , Y02A50/386 , Y02A50/412
摘要： The present invention is directed to a recombinant MVA, which carries a nucleic acid sequence coding for a fusion protein. The present invention is further directed to a kit of parts containing said recombinant MVA as well as to a method for enhancing T cell responses in a mammal.
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90.发明公开
公开(公告)号：EP2384766A1
公开(公告)日：2011-11-09
申请号：EP10004646.5
申请日：2010-05-03
申请人： Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) , Zeidler, Reinhard
IPC分类号： A61K39/395 , C07K16/30 , C07K16/40 , A61P35/00 , C12N15/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K39/39558 , C07K16/30
摘要： The present invention relates to an antibody binding to a carbonic anhydrase, wherein the antibody comprises (a) the amino acid sequences SEQ ID NOS. 1 (CDR 1), 2 (CDR 2) and 3 (CDR 3) determining the CDRs of the V H region, and the amino acid sequences SEQ ID NOS. 4 (CDR 1), 5 (CDR 2) and 6 (CDR 3) determining the CDRs of the V L region; or (b) the amino acids sequences of (a), wherein at least one amino acid is conservatively substituted in any one of the amino acid sequences SEQ ID NOS. 1 to 6.
摘要翻译： 本发明涉及与碳酸酐酶结合的抗体，其中抗体包含（a）氨基酸序列SEQ ID NO： 1（CDR1），2（CDR2）和3（CDR3），确定V H区的CDR，以及氨基酸序列SEQ ID NOS。 4（CDR1），5（CDR2）和6（CDR3），确定V L区的CDR; 或（b）（a）的氨基酸序列，其中至少一个氨基酸在任一氨基酸序列SEQ ID NOS中保守取代。 1至6。
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