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285 条记录 (耗时 0.022 秒)

    Promotor for biological hyaluronic acid synthesis, composition externally applied to the skin and use thereof
    84.
    发明公开
    Promotor for biological hyaluronic acid synthesis, composition externally applied to the skin and use thereof 失效
    启动子为生物合成透明质酸，局部应用在皮肤上的组合物及其用途。

    公开(公告)号：EP0531978A2

    公开(公告)日：1993-03-17

    申请号：EP92115436.5

    申请日：1992-09-09

    申请人： LION CORPORATION

    发明人： Hirayama, Yutaka, Lion Corporation ,  Ebata, Keiko ,  Watanabe, Shinichi

    IPC分类号： A61K35/80 ,  A61K7/48

    CPC分类号： A61K36/03 ,  A61K8/9706 ,  A61K36/05 ,  A61Q19/00 ,  A61Q19/08 ,  A61K2300/00

    摘要： A promotor for biological hyaluronic acid synthesis and a composition for external application to the skin comprise, as an effective component, an extract of the seaweed Ulva pertusa. The promotor exhibits a substantially excellent biological hyaluronic acid synthesis-promoting effect and accordingly activates the skin cells, prevents the aging thereof and the formation of wrinkles and makes the skin smooth and fresh. Thus, it can provide a highly safe agent externally applied to the skin. Consequently, the composition can widely be used in a variety of preparations such as various cosmetic creams, milky lotions, toilet waters, beauty essences, packs, under-makeups, foundations, jellies and ointments.

    摘要翻译： 一种用于生物透明质酸合成促进和用于外部施用到皮肤上的组合物包含作为有效成分的，以提取海藻孔石莼的。 所述启动子呈现基本优良生物透明质酸合成促进效果并且因此激活皮肤细胞，防止其老化和皱纹的形成和使皮肤光滑和清爽。 因此，它可以提供从外部施加到皮肤上的高度安全的药物。 如各种化妆品乳膏，乳液，化妆水，美容液，面膜，欠妆，粉底，果冻和软膏：因此，该组合物可广泛用于各种制剂中。

    Melanocyte-stimulating hormone inhibitor and external preparation containing the same
    87.
    发明公开
    Melanocyte-stimulating hormone inhibitor and external preparation containing the same 失效
    抑制剂黑素细胞刺激因子激素和呕吐物，äusserlichanwendbaresPräparat。

    公开(公告)号：EP0389950A1

    公开(公告)日：1990-10-03

    申请号：EP90105354.6

    申请日：1990-03-21

    申请人： LION CORPORATION

    发明人： Takeuchi, Takuji ,  Sato, Chikara ,  Oba, Kenkichi ,  Sugiyama, Keikichi

    IPC分类号： C07K99/10 ,  C07K5/04 ,  C07K7/04 ,  A61K37/02

    CPC分类号： A61K8/64 ,  A61K38/00 ,  A61Q19/02 ,  C07K5/1024 ,  C07K14/685 ,  C07K14/69

    摘要： A melanocyte-stimulating hormone inhibitor has an amino acid sequence represented by the following formula [I], [II] or [III] in the molecule:


    wherein His, Ser, Arg, Trp, Leu, Ala and Cys represent L- or D-histidine; serine, arginine, tryptophan, leucine, alanine and cysteine residues, respectively. The melanocyte-stimulating hormone inhibitor and an external preparation to be applied to the skin which contains the inhibitor prevent or cure the symptoms of chloasmata and freckles caused by an excess production of melanin by enhanced melanocyte function.

    摘要翻译： 黑素细胞刺激激素抑制剂在分子中具有由下式[I]，[II]或[III]表示的氨基酸序列：-His-Ser-Arg-Trp- [I] -Trp-Arg-Ser- His-Ser-Arg，Trp，Leu，Ala和Cys的His- [II] -Leu-Ala-Cys-Ala-Arg- [III]代表L-或D-组氨酸; 丝氨酸，精氨酸，色氨酸，亮氨酸，丙氨酸和半胱氨酸残基。 黑素细胞刺激激素抑制剂和外用制剂，其应用于含有该抑制剂的皮肤，可预防或治愈由增强的黑素细胞功能引起的过量黑色素产生引起的黄褐斑和雀斑的症状。

    Method for continuous preparation of highly pure monoglyceride
    88.
    发明公开
    Method for continuous preparation of highly pure monoglyceride 失效
    连续制备高纯单硬脂酸酯的方法

    公开(公告)号：EP0293001A3

    公开(公告)日：1990-05-30

    申请号：EP88108526.0

    申请日：1988-05-27

    申请人： LION CORPORATION

    发明人： Schröder, Roland ,  Oba, Kenkichi

    IPC分类号： C12P7/62 ,  C12P7/64

    CPC分类号： C12P7/6454

    摘要： A method for continuous preparation of highly pure monoglyceride comprises the steps of esterifying fatty acid dissolved in a nonpolar solvent at the interface between the nonpolar solvent phase and a polar solvent phase containing glycerol, water and dispersed lipase, the polar phase being located below the nonpolar phase, continuously taking out the nonpolar solvent phase, cooling the taken out phase to isolate the resulting monoglyceride by precipitation, and bringing back the remaining solution to the esterification system. By this method, monoglycerides having high purity can be produced continuously and at low cost, and further monoglycerides of straight-chained fatty acids can preferentially obtained even though the fatty acids used contain branched fatty acids.

    Method of producing microcapsule
    90.
    发明公开
    Method of producing microcapsule 失效
    生产微胶囊的方法

    公开(公告)号：EP0332175A2

    公开(公告)日：1989-09-13

    申请号：EP89104123.8

    申请日：1989-03-08

    申请人： LION CORPORATION

    发明人： Takizawa, Masahiro ,  Matsui, Yumiko ,  Arai, Hiroto

    IPC分类号： B01J13/02

    CPC分类号： B01J13/206 ,  A61K8/11 ,  A61K8/676 ,  A61K8/8129 ,  A61K9/5026 ,  A61K2800/412 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q19/00

    摘要： A method of producing microcapsules comprising the steps of:
    mixing (i) an aqueous dispersion containing a capsule having an wall membrane containing polyvinyl alcohol and an aqueous solution containing 8% to 50% by weight of an electrolyte or electrolytes and (ii) an aldehyde or aldehydes having a solubility in water at 20°C of not more than 10%; and
    allowing the mixture to react under an acidic condition.

    摘要翻译： 制备微胶囊的方法包括以下步骤：混合（i）含有具有包含聚乙烯醇的壁膜和含有8重量％至50重量％电解质或多种电解质的水溶液的胶囊的水性分散体，和（ii） 或在20℃在水中的溶解度不超过10％的醛; 并使混合物在酸性条件下反应。