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    Bis(thio-hydrazide amide) salts for treatment of cancers
    88.
    发明公开
    Bis(thio-hydrazide amide) salts for treatment of cancers 审中-公开
    BIS（THIOHYDRAZIDAMID）SALZE ZUR BEHANDLUNG VON KREBS

    公开(公告)号：EP2305642A2

    公开(公告)日：2011-04-06

    申请号：EP10009536.3

    申请日：2005-06-20

    申请人： Synta Pharmaceuticals Corp.

    发明人： Kostik, Elena ,  Vaghefi, Farid ,  Liang, Guiqing ,  Koya, Keizo ,  Sun, Lijun ,  Tatsuta, Noriaki ,  Chen, Shoujun ,  Inoue, Takayo ,  Xia, Zhi-Qiang

    IPC分类号： C07C327/56 ,  A61K31/16 ,  A61P35/00

    CPC分类号： C07D305/14 ,  C07C327/56 ,  C07C2601/02

    摘要： Disclosed are bis(thio-hydrazide amide) disalts, which are represented by Structural Formula (I)

             2 M + or M 2+ Y is a covalent bond or a substituted or unsubstituted straight chained hydrocarbyl group. R 1 -R 4 are independently -H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group, or R 1 and R 3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R 2 and R 4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. Z is -O or -S. M + is a pharmaceutically acceptable monovalent cation and M 2+ is a pharmaceutically acceptable divalent cation. Also disclosed are pharmaceutical compositions comprising a bis(thio-hydrazide amide) disalt described above. Further disclosed are methods of treating a subject with cancer. The methods comprise the step of administering an effective amount of a bis(thio-hydrazide amide) disalt.

    摘要翻译： 公开了由结构式（I）表示的双（硫代 - 酰肼酰胺）缬氨酸，它们是共价键或一个或多个 取代或未取代的直链烃基。 R 1 -R 4独立地为-H，脂族基团，取代的脂族基团，芳基或取代的芳基，或者R 1和R 3与它们所键合的碳原子和氮原子一起，和/ 或R 2和R 4与它们所键合的碳原子和氮原子一起形成任选地与芳环稠合的非芳族杂环。 Z是-O或-S。 M +是药学上可接受的一价阳离子，M 2+是药学上可接受的二价阳离子。 还公开了包含上述双（硫代 - 酰肼酰胺）二盐的药物组合物。 进一步公开的是用癌症治疗受试者的方法。 所述方法包括给予有效量的双（硫代 - 酰肼酰胺）二盐的步骤。