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    SYNERGISTIC COMBINATIONS OF ZIDOVUDINE, 1592U89 AND 3TC
    84.
    发明授权
    SYNERGISTIC COMBINATIONS OF ZIDOVUDINE, 1592U89 AND 3TC 失效
    作者齐多夫定，1592U89和3TC协同组合

    公开(公告)号：EP0817637B1

    公开(公告)日：2002-07-17

    申请号：EP96911953.6

    申请日：1996-03-28

    申请人： THE WELLCOME FOUNDATION LIMITED

    发明人： BARRY, David, Walter ,  ST. CLAIR, Martha, Heider Glaxo Wellcome Inc.

    IPC分类号： A61K31/70 ,  A61P31/18 ,  A61P31/12

    CPC分类号： A61K31/70 ,  A61K31/505 ,  A61K2300/00

    摘要： The present invention relates to therapeutic combinations of (1S,4R)-cis-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1592U89), 3'-azido-3'-deoxythymidine (zidovudine) and (2R,cis)-4-amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (3TC) (or, alternatively to 3TC, (2R,cis)-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one (FTC)) which have anti-HIV activity. The present invention is also concerned with pharmaceutical compositions containing said combinations and their use in the treatment of HIV infections including infections with HIV mutants bearing resistance to nucleoside and/or non-nucleoside inhibitors.

    INHALATION DEVICE
    88.
    发明公开
    INHALATION DEVICE 失效
    吸入装置

    公开(公告)号：EP0835146A2

    公开(公告)日：1998-04-15

    申请号：EP95932737.0

    申请日：1995-09-13

    申请人： LABORATOIRE GLAXO WELLCOME

    发明人： SCHAEFFER, Alain, Emile, Edouard ,  SEGUELAS, Etienne, APE Medical

    IPC分类号： A61M ,  A61M15

    CPC分类号： A61M15/0065 ,  A61M15/0068 ,  A61M2202/064 ,  G06F19/00

    摘要： An inhalation device is provided by means of which material in powder form can be inhaled. The device comprises a body (55) defining a reservoir (56) for medicaments in powder form, an outlet (57) through which a user can inhale and a dosing member (53) with at least one metering recess (65) formed therein. The dosing member (53) is moveable between a position in which the at least one metering recess (65) communicates with the reservoir (56) to receive a dose of powder therefrom and a position in which the at least one metering recess (65) communicates with the outlet (57) to permit the user to inhale the dose. The at least one metering recess (65) is formed in a face of the dosing member (53), the said face being mounted in contact against a similar mating face (60) of the body (55) at the lower end of the reservoir (56). At least one moveable weight may be incorporated within the device, adapted to strike an anvil surface when the device is shaken.

    摘要翻译： 提供吸入装置，借助于吸入装置可以吸入粉末形式的材料。 该装置包括限定用于粉末形式的药物的贮存器（56）的主体（55），用户可以吸入的出口（57）和具有至少一个计量凹槽（65）的计量构件（53）。 定量给料件（53）可在至少一个计量凹槽（65）与贮存器（56）连通以从其接收粉末剂量的位置与其中至少一个计量凹槽（65） 与出口（57）连通以允许使用者吸入剂量。 所述至少一个计量凹槽（65）形成在所述定量给料构件（53）的表面中，所述表面安装成在所述贮存器的下端处抵靠所述本体（55）的类似配合面（60） （56）。 至少一个可移动的重物可以被结合在装置内，适于在装置被摇动时撞击砧座表面。

    Surfactant free aerosol formulations containing bezlomethsone dipropionate
    90.
    发明公开
    Surfactant free aerosol formulations containing bezlomethsone dipropionate 失效
    气雾剂喷雾剂贝司洛沙坦

    公开(公告)号：EP0775484A1

    公开(公告)日：1997-05-28

    申请号：EP97101101.0

    申请日：1993-07-30

    申请人： GLAXO GROUP LIMITED

    发明人： Taylor, Anthony James ,  Neale, Philip John

    IPC分类号： A61K9/00 ,  A61K31/57

    CPC分类号： A61K9/008 ,  A61K31/57 ,  A61K31/573

    摘要： This invention relates to novel aerosol formulations for administering drugs, in particular for administration of a beclomethasone ester by inhalation.
    In particular this invention provides a novel aerosol formulation consisting essentially of particulate anhydrous beclomethasone dipropionate together with 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant.

    摘要翻译： 本发明涉及用于给药的新型气溶胶制剂，特别是用于通过吸入给药倍氯米松酯。 特别地，本发明提供了一种新型的气溶胶制剂，其基本上由二丙酸微粒无水倍氯米松与1,1,1,2,3,3,3-七氟正丙烷作为推进剂组合。