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公开(公告)号：EP0815440A1
公开(公告)日：1998-01-07
申请号：EP96909803.0
申请日：1996-03-20
CPC分类号： G01N27/44782 , B01L9/065 , G01N27/44743 , G01N2035/00237
摘要： This invention involves method and apparatus for multiplexing electrophoresis analysis. An array of samples in multi well plates are simultaneously transferred to an array of electrophoresis column where electrophoresis is simultaneously carried out followed by analysis of the columns. The methods and apparatus of this invention are, for example, useful for DNA analysis, including sequencing, and for measuring reactions between specifically binding proteins and their binding partners.
摘要翻译： 本发明涉及多路复用电泳分析的方法和装置。 将多孔板中的样品阵列同时转移至电泳柱的阵列中，同时进行电泳，然后分析柱。 例如，本发明的方法和装置可用于DNA分析，包括测序，以及用于测量特异性结合蛋白与其结合配偶体之间的反应。
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公开(公告)号：EP0814810A1
公开(公告)日：1998-01-07
申请号：EP96909686.0
申请日：1996-03-13
CPC分类号： A61K31/7076 , A61K31/70 , A61K2300/00
摘要： Disclosed are adenosine A2 receptor agonists for use in increasing the contractile performance of a compromised myocardium in a mammal. The agonists are administered in a therapeutically effective amount. Also disclosed are additional compounds, e.g., an adenosine transport inhibitor, an inhibitor of adenosine metabolism or an adenosine A1 receptor antagonist, that potentiate the beneficial effect of the adenosine A2 receptor agonist when administered in conjunction with the agonist.
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83.发明公开SUBSTITUTED o-AMINOCARBONYLBENZOIC ACID SALTS AND THEIR USE AS SUNSCREENS 失效取代的邻AMINOCARBONYLBENZOESÄURESALZE及其作为光保护产品
公开(公告)号：EP0814760A1
公开(公告)日：1998-01-07
申请号：EP97901444.0
申请日：1997-01-14
申请人： STEPAN COMPANY
发明人： GEORGE, Liliana , SOTTERY, John
摘要： Disclosed are methods and compositions for increasing the sun protection factor of oil and water sunscreen emulsions comprising adding a phthalic acid derivative to an oil and water sunscreen emulsion in an amount effective to increase the sun protection factor of the emulsion, the phthalic acid derivative having general formula (I) where R represents an organic substituent, X represents a cation, and m is an integer satisfying the valency of X.
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公开(公告)号：EP0807171A1
公开(公告)日：1997-11-19
申请号：EP95943748.0
申请日：1995-12-12
申请人： HYBRIDON, Inc.
CPC分类号： C12N15/113 , C12N15/1132 , C12N2310/315
摘要： Disclosed is a method for synthesizing of stereospecific (Rp) phosphorothioate oligonucleotides. In this method, a primer comprising a plurality of deoxyribonucleotides and a ribonucleotide at the 5' terminal or 5' penultimate position, is annealed to a template. The structure is contacted with a mixture of deoxynucleoside α-triphosphate Sp diastereomers and a DNA polymerase to form a PS-Rp oligodeoxynucleotide extension which is liberated as a single-stranded PS-Rp oligonucleotide by cleavage after the ribonucleotide in the primer. Also disclosed are PS-Rp oligonucleotides and oligonucleotides prepared according to this method.
摘要翻译： 公开了用于合成立体特异性（Rp）硫代磷酸寡核苷酸的方法。 在该方法中，将包含多个脱氧核糖核苷酸和在5'末端或5'倒数第二位置处的核糖核苷酸的引物退火至模板。 使该结构与脱氧核苷α-三磷酸Sp非对映异构体和DNA聚合酶的混合物接触以形成PS-Rp寡脱氧核苷酸延伸，其通过引物中的核糖核苷酸之后的切割作为单链PS-Rp寡核苷酸释放。 还公开了根据该方法制备的PS-Rp寡核苷酸和寡核苷酸。
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85.发明公开INHIBITION OF NEOVASCULARIZATION USING VEGF-SPECIFIC OLIGONUCLEOTIDES 失效VEGF NEOVASKULASIERUNG的抑制特异性寡核苷酸
公开(公告)号：EP0805858A2
公开(公告)日：1997-11-12
申请号：EP96905270.0
申请日：1996-01-26
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/3125 , C12N2310/314 , C12N2310/315 , C12N2310/316 , C12N2310/317 , C12N2310/321 , C12N2310/3521 , C12N2310/53 , C12N2310/3527
摘要： Disclosed are methods of reducing neovascularization and of treating various disorders associated with neovascularization. These methods include administering to a tissue or subject a synthetic oligonucleotide specific for vascular endothelial growth factor nucleic acid effective in inhibiting the expression of vascular endothelial growth factor.
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公开(公告)号：EP0805836A2
公开(公告)日：1997-11-12
申请号：EP96903661.0
申请日：1996-01-24
CPC分类号： C09D11/50
摘要： A fluorescent ink comprises, as primary constituents, long-wave activated inorganic phosphor pigment and acrylic resin, with the ink being fluorescent under long-wave ultraviolet radiation. A fluorescent display device comprises a long-wave ultraviolet light sources and a display panel, with the panel imprinted with the described fluorescent ink.
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87.发明公开HYBRIDIZATION AND FOOTPRINTING METHODS TO CHARACTERIZE THE INTERACTIONS OF 16S rRNA ANALOGUES FOR IDENTIFICATION OF NOVEL ANTIBIOTICS 失效杂交和施加过程表示特征的和互动的16S rRNA模拟确定新的抗生素
公开(公告)号：EP0804454A1
公开(公告)日：1997-11-05
申请号：EP95930926.0
申请日：1995-08-23
发明人： STERN, Seth , PUROHIT, Prakash
IPC分类号： C12Q1
CPC分类号： C12Q1/689 , C12Q1/6811 , C12Q1/6888
摘要： The oligoribonucleotide analogs of the invention, as exemplified in the figure, are relatively small, three-dimensional structures derived from larger parental RNA molecules. The analogs include a first nucleic acid structure including one or more nucleotide sequences that are derived from a region of parental RNA, wherein in its native state, the region binds to a ligand, e.g., an aminoglycoside, with a parental RNA ligand binding pattern, and a second nucleic acid structure including one or more nucleotide sequences combined with the first nucleic acid structure to form the analog and provide the analog with a conformation that binds the ligand with a ligand binding pattern that is substantially identical to the parental RNA ligand binding pattern. These analogs can be used to identify novel therapeutic compounds.
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公开(公告)号：EP0794781A1
公开(公告)日：1997-09-17
申请号：EP95944530.0
申请日：1995-12-28
发明人： WRIGHT, George, E.
CPC分类号： C07D473/00 , C07D473/18 , C07H19/16
摘要： N2-substituted alkylguanines and N2-substituted phenylguanine compounds which prevent recurrent herpes simplex infections are disclosed. By virtue of their ability to inhibit herpes virus thymidine kinase in vivo, such compounds will prevent, reduce the frequency of, or reduce the severity of recurrent HSV infections in humans.
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89.发明公开
公开(公告)号：EP0792336A2
公开(公告)日：1997-09-03
申请号：EP96932244.0
申请日：1996-09-17
申请人： STEPAN COMPANY
发明人： SAJIC, Branko , RYKLIN, Irma , MALIK, Arshad , RAO, Y., Kameshwer
CPC分类号： C11D1/28 , C11D1/146 , C11D1/22 , C11D1/29 , C11D1/525 , C11D1/662 , C11D1/72 , C11D1/83 , C11D1/831 , C11D1/86 , C11D3/0036
摘要： Disclosed are detergent compositions comprising: (a) an alpha -sulfonated alkyl ester of a fatty acid having an average of about 12-16 carbon atoms; (b) an anionic surfactant; and (c) a nonionic surfactant, and methods for preparing such compositions. Also disclosed are methods for inhibiting redeposition of soil on fabric, in which the fabric is treated with a detergent comprising a salt of an alpha -sulfonated fatty acid having from about 8-22 carbon atoms.
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90.发明公开USE OF SUBSTITUTED ARYL-MORPHOLINO-, THIOMORPHOLINO- OR PIPERAZINO-PROPANONES FOR THE TREATEMENT OF PREVENTION OF ALZHEIMER'DISEASE 失效取代的芳基吗啉，-THIOMORPHOLINO或哌嗪PROPANONDERIVATEN用于治疗或预防阿尔茨海默氏病的用途
公开(公告)号：EP0792151A2
公开(公告)日：1997-09-03
申请号：EP95940750.0
申请日：1995-11-16
CPC分类号： A61K31/495 , A61K31/4453 , A61K31/5375 , A61K31/5377 , A61K31/54
摘要： Disclosed are compounds of formula (I), wherein X is selected from oxygen, sulfur and NR; wherein R is selected from hydrogen, lower alkyl and CH2CH2COAr1; and Z is hydrogen; straight or branched chain alkyl having 1-6 carbon atoms; or Z and R1, R2 or R3 together represent CH2; CH2CH2; CH2O; or CH2S forming a five or six membered ring and such ring may be optionally substituted with lower alkyl or phenyl; R24 is hydrogen; lower alkyl, or optionally substituted phenyl; each R10 is selected from hydrogen and lower alkyl; and Ar1 represents an aryl group or optionally substituted phenyl, thienyl or optionally substituted thienyl; or the pharmaceutically acceptable salts thereof, useful for preventing or decreasing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore, useful for treating Alzheimer's Disease.
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