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    CD5 SPECIFIC T CELL RECEPTOR CELL OR GENE THERAPY
    85.
    发明公开
    CD5 SPECIFIC T CELL RECEPTOR CELL OR GENE THERAPY 审中-公开

    公开(公告)号：EP3760217A1

    公开(公告)日：2021-01-06

    申请号：EP19183694.9

    申请日：2019-07-01

    申请人： Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft ,  Charité - Universitätsmedizin Berlin

    发明人： PEZZUTTO, Antonio ,  BLANKENSTEIN, Thomas ,  CAKMAK-GÖRÜR, Nese

    IPC分类号： A61K38/17 ,  C07K14/725 ,  C07K14/705

    摘要： The present invention is directed to the field of immunotherapy, in particular, adoptive T cell therapy or T cell receptor (TCR) gene therapy of cancer. The invention provides a nucleic acid encoding at least one TCR alpha or beta chain construct of a TCR construct capable of specifically binding to a peptide from the T-cell lineage specific antigen CD5, preferably SEQ ID NO: 1, in the context of a human MHC I such as HLA-A*02, in particular HLA-A*02:01. The invention also provides corresponding proteins and host cells, preferably, CD8+ T cells, expressing said TCR construct. Treatment optionally is in the context of allogeneic stem cell transplantation, in particular, mismatch-transplantation, or haploidentical transplantation, or in combination with an agent capable of inhibiting expression of HLA-A*02 in the TCR-transgenic T cells. The invention thus also provides compositions and kits comprising the nucleic acids of the invention in combination with an agent capable of inhibiting expression of HLA-A*02, and, as well as the medical use of such compositions and kits. The nucleic acids, compositions and kits, proteins or host cells may be for use in the diagnosis, prevention and/or treatment of a CD5-positive T-cell lymphoma or T-cell leukemia, no matter whether the antigen is expressed on the cell surface, intracytoplasmic or in both manners.

    METHOD FOR AUTOMATIC SHAPE QUANTIFICATION OF AN OPTIC NERVE HEAD
    88.
    发明公开
    METHOD FOR AUTOMATIC SHAPE QUANTIFICATION OF AN OPTIC NERVE HEAD 审中-公开

    公开(公告)号：EP3633604A1

    公开(公告)日：2020-04-08

    申请号：EP18198717.3

    申请日：2018-10-04

    申请人： Charité Universitätsmedizin Berlin

    发明人： BRANDT, Alexander ,  KADAS, Ella Maria ,  YADAV, Sunil Kumar ,  MOTAMEDI, Seyedamirhosein ,  PAUL, Friedemann

    IPC分类号： G06T7/00 ,  G06T7/12 ,  G06T7/149 ,  G06T7/62

    摘要： The invention relates to a method and a computer program for automatic shape quantification of an optic nerve head from three-dimensional image data (1) acquired with optical coherence tomography, comprising the steps of:
    a) Providing (100) three-dimensional image data (1) of the retina, the image data comprising at least a portion of the optic nerve head, wherein the image data comprises pixels with associated pixel values;
    b) In the three-dimensional image data (1) identifying (200, 300) anatomic portions of the optic nerve head, the anatomic portions comprising a retinal pigment epithelium (RPE) portion (3) and an inner limiting membrane (ILM) portion (2);
    c) Determining an RPE polygon mesh (30) for a lower boundary of the retinal pigment epithelium portion (3), wherein the RPE polygon mesh (30) extends along the lower boundary of the retinal pigment epithelium portion (3);
    d) Determining an ILM polygon mesh (20) for the inner limiting membrane portion (2), wherein the ILM polygon mesh (20) extends along the inner limiting membrane portion (2);
    e) Determining a morphologic parameter (10) of the optic nerve head from the RPE polygon mesh (30) and the ILM polygon mesh (20);
    f) Displaying the morphologic parameter (10) of the optic nerve head and/or a representation of at least a portion of the RPE polygon mesh (30) and/or a representation of at least a portion of the ILM polygon mesh (20).