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公开(公告)号：EP4029854A1
公开(公告)日：2022-07-20
申请号：EP21212372.3
申请日：2013-07-15
申请人： Fibrogen, Inc.
发明人： WITSCHI, Claudia , PARK, Jung Min , THOMPSON, Michael D. , MARTINELLI, Michael John , YEOWELL, David A. , AREND, Michael P.
IPC分类号： C07D217/26
摘要： The present disclosure relates to crystalline solid forms of [(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid, the process of preparing the forms, and pharmaceutical compositions and methods of use thereof.
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公开(公告)号：EP3003284B1
公开(公告)日：2020-02-12
申请号：EP14735770.1
申请日：2014-06-05
申请人： Fibrogen, Inc.
发明人： CONCA, David , FLIPPIN, Lee, Allen , LEIGH, Scott, David , WITSCHI, Claudia , WRIGHT, Lee, Robert
IPC分类号： A61K9/28 , A61K9/48 , A61K31/472 , A61K9/20
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83.发明授权
公开(公告)号：EP2951159B1
公开(公告)日：2018-08-22
申请号：EP14704030.7
申请日：2014-01-23
申请人： Fibrogen, Inc.
IPC分类号： C07D217/26 , A61K31/472 , A61P7/06
CPC分类号： C07D217/26
摘要： The present disclosure relates to crystalline forms of {[1-cyano-5-(4-chlorophenoxy)-4-hydroxy-isoquinoline-3-carbonyl]-amino}-acetic acid (Compound A), the process of preparing crystalline forms of Compound A, the pharmaceutical compositions containing them, and the methods of use thereof.
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公开(公告)号：EP2298301B1
公开(公告)日：2018-07-04
申请号：EP10181796.3
申请日：2002-12-06
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen J. , LIN, Al Y. , NEFF, Thomas B. , WANG, Qingjian , GUENZLER-PUKALL, Volkmar , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： A61K31/47 , A61K31/4738 , A61K31/63 , A61K38/17 , A61K31/00 , C07K14/47 , C07K14/505 , A61P7/06 , G01N33/74 , C12N15/09 , C12Q1/34 , C12Q1/56 , A61K31/472 , A61K31/4745 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/496
CPC分类号： A61K31/4745 , A61K31/00 , A61K31/17 , A61K31/4375 , A61K31/44 , A61K31/4418 , A61K31/47 , A61K31/472 , A61K31/4738 , A61K31/496 , A61K31/63 , A61K38/1709 , C07K14/4702 , C07K14/505 , G01N33/746
摘要： The present invention relates to methods of stabilizing the alpha subunit of hypoxia inducible factor (HIF). The invention further relates to methods of preventing, pretreating, or treating conditions associated with HIF, including ischemic and hypoxic conditions. Compounds for use in these methods are also provided.
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85.发明授权
公开(公告)号：EP2670750B1
公开(公告)日：2016-09-14
申请号：EP12704581.3
申请日：2012-02-01
申请人： Fibrogen, Inc.
发明人： NG, Danny , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/10
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C12N9/0071 , C12Y114/11002 , C12Y114/1103
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86.发明授权USE OF HIF ALPHA STABILIZERS FOR ENHANCING ERYTHROPOIESIS 有权VERWENDUNG VON HIF ALPHA STABILISATOREN ZUR STEIGERUNG DER ERYTHROPOESE
公开(公告)号：EP1633333B1
公开(公告)日：2014-08-20
申请号：EP04754383.0
申请日：2004-06-04
申请人： Fibrogen, Inc.
发明人： KLAUS, Stephen, J. , MOLINEAUX, Christopher, J. , NEFF, Thomas, B. , GUENZLER-PUKALL, Volkmar , LANSETMO PAROBOK, Ingrid , SEELEY, Todd, W. , STEPHENSON, Robert, C.
IPC分类号： A61K31/00 , A61K31/395 , A61K31/165 , A61P7/06
CPC分类号： C07D217/24 , A61K31/00 , A61K31/165 , A61K31/17 , A61K31/395 , A61K31/472 , C07C275/40
摘要： The present invention relates to methods and compounds for regulating or enhancing erthropoiesis and iron metabolism, and for treating or preventing iron deficiency and anemia of chronic disease.
摘要翻译： 本发明涉及用于调节或增强红细胞生成和铁代谢以及治疗或预防慢性疾病的铁缺乏和贫血的方法和化合物。
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87.发明授权ISOXAZOLOPYRIDINE DERIVATIVES FOR USE IN THE TREATMENT OF HIF-MEDIATED CONDITIONS 有权ISOXAZOLOPYRIDINDERIVATE FOR USE IN HIF分别赋以处理交换式莱顿
公开(公告)号：EP2227475B1
公开(公告)日：2014-02-19
申请号：EP08857227.6
申请日：2008-12-02
申请人： Fibrogen, Inc.
发明人： AREND, Michael P. , CHENG, Heng , FLIPPIN, Lee A. , NG, Danny , TURTLE, Eric , WU, Min
IPC分类号： C07D498/04 , A61K31/437 , A61P7/00 , A61P9/00
CPC分类号： C07D498/04
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88.发明公开NAPHTHYRIDINE DERIVATIVES AS INHIBITORS OF HYPOXIA INDUCIBLE FACTOR (HIF) HYDROXYLASE 有权萘啶，缺氧诱导因子抑制剂（HIF）羟化酶
公开(公告)号：EP2670750A1
公开(公告)日：2013-12-11
申请号：EP12704581.3
申请日：2012-02-01
申请人： Fibrogen, Inc.
发明人： NG, Danny , AREND, Michael P. , FLIPPIN, Lee A.
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/10
CPC分类号： C07D471/04 , A61K31/4375 , A61K31/444 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/06 , C12N9/0071 , C12Y114/11002 , C12Y114/1103
摘要： The present disclosure relates to novel compounds, methods, and compositions capable of inhibiting HIF hydroxylase enzyme activity, thereby increasing the stability and/or activity of hypoxia inducible factor (HIF).
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89.发明授权ISOTHIAZOLE-PYRIDINE DERIVATIVES AS MODULATORS OF HIF (HYPOXIA INDUCIBLE FACTOR) ACTIVITY 有权HIF（缺氧诱导因子）活性的ISOTHIAZOLPYRIDINDERIVATE AS调节剂
公开(公告)号：EP2252619B1
公开(公告)日：2013-10-09
申请号：EP09700287.7
申请日：2009-01-12
申请人： Fibrogen, Inc.
发明人： ZHOU, Xiaoti , AREND, Michael, P. , WU, Min , FLIPPIN, Lee, A.
IPC分类号： C07D513/04 , A61K31/4353 , A61P9/00
CPC分类号： A61K31/437 , A61K31/497 , A61K45/06 , C07D513/04
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公开(公告)号：EP1434993B1
公开(公告)日：2013-04-24
申请号：EP02761695.2
申请日：2002-09-18
申请人： Fibrogen, Inc.
CPC分类号： G01N33/6887 , G01N33/74
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