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213 条记录 (耗时 0.024 秒)

    ASSAY FOR METASTATIC COLORECTAL CANCER
    85.
    发明公开
    ASSAY FOR METASTATIC COLORECTAL CANCER 审中-公开
    测试程序转移性结直肠癌

    公开(公告)号：EP2078204A2

    公开(公告)日：2009-07-15

    申请号：EP07852996.3

    申请日：2007-10-29

    申请人： George Mason Intellectual Properties, Inc. ,  Istituto Superiore di Sanità

    发明人： PETRICOIN, III Emanuel ,  LIOTTA, Lance A. ,  PIEROBON, Mariaelena ,  CALVERT, Valerie

    IPC分类号： G01N33/574 ,  G01N33/68

    CPC分类号： G01N33/57419 ,  C12Q1/485 ,  G01N2333/90245

    摘要： This invention relates, e.g., to a method for predicting the prognosis, the likelihood of metastasis in, or the desirability of administering an aggressive therapy to, a subject with colorectal cancer, comprising determining, in a sample from the subject, the level of phosphorylation compared to a positive and/or negative reference standard, of one or more of: (a) AKT (S473); (b) BAD (S l 12); (c) cABL (T735); (d) ERK (T42/44); (e) MARCKS (S 152- 156); (0 p38MAPK (T l 80- 182): (g) STAT l (Y701 ); (h) PTEN (S380); (i) EGFR (Y992); (j) PAK 1 /2 (S l 19/204); or (k) PKC zeta/lambda (T410-403); or the total amount of (1) COX-2 protein; wherein if the level of phosphorylation of one or more of a-i or the total amount of COX-2 protein (1) is elevated compared to the negative reference standard, and/or i f the level of phosphorylation of j or k is decreased compared to the positive reference standard, the subject has poor prognosis, is likely to undergo metastasis, and/or is a good candidate for aggressive therapy. Also described are methods for treating subjects likely to develop metastatic colorectal carcinoma, and pharmaceutical compositions and kits for implementing methods of the invention.

    METHODS AND KITS FOR SELECTING AN ANALGESIC REGIME
    86.
    发明公开
    METHODS AND KITS FOR SELECTING AN ANALGESIC REGIME 审中-公开
    方法和试剂盒用于选择治疗方案ANALGESIA-

    公开(公告)号：EP2052257A1

    公开(公告)日：2009-04-29

    申请号：EP07789030.9

    申请日：2007-07-20

    申请人： Knox, Geoffrey Malcolm

    发明人： Knox, Geoffrey Malcolm

    IPC分类号： G01N33/94 ,  G01N33/52

    CPC分类号： G01N33/9486 ,  G01N2333/90245 ,  G01N2800/52

    摘要： A method is provided for selecting an analgesic regime for treatment of a patient. In the method, a body fluid sample from the patient is assayed for the presence of a metabolite produced by metabolism of a prodrug. If the metabolite is present in the body fluid sample this indicates that a suitable analgesic regime for the patient should comprise administration of at least one analgesic agent selected from the group consisting of: codeine and tramadol. If the metabolite is absent from the body fluid sample indicates that a suitable analgesic regime for the patient should comprise administration of an analgesic agent selected from the group consisting of: dihydrocodeine; buprenorphine and propoxyphene. The invention also provides a kit for selecting an analgesic regime for a patient. The kit comprises means for assaying for the presence of a metabolite produced by metabolism of a prodrug and instructions for using the provided means to perform the method as described above.

    Methods of measuring human cytochrome P450 (CYP2C8/9)
    88.
    发明公开
    Methods of measuring human cytochrome P450 (CYP2C8/9) 审中-公开
    方法Zur Messung von menschlichen Cytochrom P450（CYP2C8 / 9）

    公开(公告)号：EP2000532A1

    公开(公告)日：2008-12-10

    申请号：EP08105435.5

    申请日：2000-08-01

    申请人： Merck & Co., Inc.

    发明人： Mei, Qin ,  Rushmore, Thomas H. ,  Shou, Magang

    IPC分类号： C12N15/02 ,  C12N15/06 ,  C12N15/08 ,  C07K16/00 ,  C12P21/08 ,  G01N33/53 ,  A61K39/00 ,  C07K16/40 ,  C12N9/02

    CPC分类号： C12Q1/26 ,  C07K16/40 ,  C12N2799/026 ,  G01N33/573 ,  G01N2333/795 ,  G01N2333/80 ,  G01N2333/90245

    摘要： Monoclonal antibodies (MAbs) have been developed to human cytochrome P450 2C8/9 (CYP2C8/9) by the fusion of myeloma tumour cells with isolated B-lymphocytes from spleens of mice immunised with baculovirus-expressed human CYP2C9; the MAbs for CYP2C9 are very powerful inhibitors of CYP2C8/9 activity and stray binders of the enzymes on Western blot and exhibit no cross-reactivity towards any of the other P450 subfamily members; based on these features the MAbs are useful tools for measuring CYP2C8/9 and assessing the role of CY2C8/9 in the metabolism of various compounds.

    摘要翻译： 已经通过骨髓瘤肿瘤细胞与用杆状病毒表达的人CYP2C9免疫的小鼠的脾脏分离的B淋巴细胞融合，开发了单克隆抗体（MAb）到人细胞色素P450 2C8 / 9（CYP2C8 / 9）; CYP2C9的MAb是蛋白质印迹的CYP2C8 / 9活性和酶的杂散结合物的非常强大的抑制剂，并且对任何其他P450亚族成员都没有交叉反应性; 基于这些特征，MAb是测量CYP2C8 / 9和评估CY2C8 / 9在各种化合物代谢中的作用的有用工具。

    ANALYSEVERFAHREN ZUR BESTIMMUNG EINES ORGANFUNKTIONSPARAMETERS UNTER BEVORZUGTER VERWENDUNG EINER WÄSSRIGEN 13C-METHACETIN-LÖSUNG
    89.
    发明公开
    ANALYSEVERFAHREN ZUR BESTIMMUNG EINES ORGANFUNKTIONSPARAMETERS UNTER BEVORZUGTER VERWENDUNG EINER WÄSSRIGEN 13C-METHACETIN-LÖSUNG 有权
    水性13C沙西解决方案

    公开(公告)号：EP1896846A2

    公开(公告)日：2008-03-12

    申请号：EP06761702.7

    申请日：2006-06-26

    申请人： Freie Universität Berlin ,  Charité-Universitätsmedizin Berlin

    发明人： STOCKMANN, Martin ,  RIECKE, Björn

    IPC分类号： G01N33/497 ,  A61K51/00 ,  A61B5/097 ,  A61B5/083 ,  A61M16/06

    CPC分类号： A61K49/10 ,  A61B5/00 ,  A61B5/0836 ,  A61B5/097 ,  A61B5/413 ,  A61B5/4244 ,  A61K49/0004 ,  A61K51/04 ,  A61M16/06 ,  A61M16/0858 ,  C12Q1/26 ,  G01N33/497 ,  G01N2333/90245 ,  Y10S436/90

    摘要： The invention relates to an analysis method for determining a functional parameter of an organ of a human or animal individual by measuring the 13CO2 content in the air exhaled by the individual to which a substrate has been administered the reaction of which in the body of the individual enriches the air exhaled by the individual with 13CO2. The method is characterized by using a measuring device, the maximum reaction rate of the substrate in the body of the individual being determined via a change of the measured 13CO2 content in the air exhaled by the individual using zero-order enzyme kinetics. The invention also relates to an aqueous methacetin solution for use in said analysis method, the pH of the solution being greater 7.0. The invention also relates to a face mask (1) for use in the inventive method for separating the exhaled air from the air inhaled by an individual. Said face mask comprises a face mask body (2) and an air cushion (3) encircling the face mask body. Said air cushion is filled with a gas and establishes a substantially gas-tight contact between the face of the individual and the face mask (1) placed on the face of the individual so that the air required by the individual for breathing and the air exhaled by the individual has to flow essentially completely through the face mask (1). At least one exhalation valve (5) and at least one inhalation valve (4) are integrated into the face mask and allow a flow of inhaled and exhaled air through the face mask. The invention finally relates to a diagnostic method for determining the functional parameters of an organ of a human or animal individual.