公开(公告)号：EP0904539A4

公开(公告)日：2002-01-30

申请号：EP97916745

申请日：1997-03-12

申请人： GEN HOSPITAL CORP ,  INDIANA UNIVERSITY FOUNDATION

发明人： AVRUCH JOSEPH ,  LUO ZHUJUN ,  MARSHAIL MARK S

IPC分类号： A61K38/00 ,  A61K45/00 ,  A61P35/00 ,  C07K5/04 ,  C07K7/04 ,  C07K14/435 ,  C07K14/82 ,  C12N5/06 ,  C12N9/12 ,  C12N15/09 ,  C12Q1/02 ,  C12Q1/48 ,  G01N33/15 ,  G01N33/50 ,  G01N33/566 ,  G01N33/53 ,  A01N37/18 ,  G01N33/574

CPC分类号： G01N33/5011 ,  A61K38/00 ,  C07K14/82 ,  C12N9/12

摘要： The invention discloses methods of inhibiting direct binding of Ras with Raf and screening methods to identify compounds which inhibit direct binding of Ras to Raf, Raf activation, and cell proliferation.

公开(公告)号：EP0830373A4

公开(公告)日：2001-09-19

申请号：EP96913873

申请日：1996-04-29

申请人： UNIV DUKE ,  SQUIBB BRISTOL MYERS CO

发明人： HAYNES BARTON F ,  ARUFFO ALEJANDRO ,  PATEL DHAVALKUMAR ,  BOWEN MICHAEL A ,  MARQUARDT HANS

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61P37/06 ,  C07K14/705 ,  C07K14/725 ,  C07K16/28 ,  C12N5/10 ,  C12N15/09 ,  C12N15/12 ,  C12P21/00 ,  C12R1/91 ,  C07K7/04 ,  A61K38/17 ,  C07K14/47 ,  C12N15/11 ,  C12N15/63

CPC分类号： C07K14/70503 ,  A61K38/00 ,  C07K16/2803 ,  C07K2319/30

公开(公告)号：EP0636029B1

公开(公告)日：2000-11-08

申请号：EP93907209.6

申请日：1993-03-05

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： KUFE, DOnald

IPC分类号： A61K39/00 ,  A61K39/395 ,  C07K16/30 ,  C07K7/04 ,  C12P21/06 ,  G01N33/53

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/00 ,  A61K47/6855 ,  A61K51/1051 ,  A61K2123/00 ,  C07K16/3015 ,  C07K2317/34

摘要： A monoclonal antibody which binds preferentially to unglycosylated DF3 antigen, compared to mature DF3 antigen, and which is specific for an epitope within the following amino acid sequence: T7R8P9A10P11G12S13, which epitope includes a proline at position 11.

公开(公告)号：EP0589993B1

公开(公告)日：1999-05-26

申请号：EP92912543.3

申请日：1992-06-16

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： ALVAREZ, Fernando

IPC分类号： C12N15/53 ,  C07K7/04 ,  C12P21/08 ,  G01N33/576 ,  A61K39/395 ,  G01N33/68

CPC分类号： C12N9/0077 ,  A61K38/00 ,  C07K16/40 ,  Y10S435/975 ,  Y10S436/811 ,  Y10S436/82 ,  Y10S530/868

摘要： Human P450 IID6 cytochrome-derived peptide fragments, anti peptide anti fragment antibodies and applications thereof in the diagnosis of autoimmune hepatitis and more especially in the differential diagnosis between autoimmune hepatitis and other chronc viral forms of hepatitis, such as hepatitis C or B. Said human P450 cytochrome peptide fragment contains at least one P450 IID6 cytochrome immunodominant epitope and consists of an amino acid sequence comprising from 3 to 70 amino acids. Said peptide binds specifically with anti-LKM auto-antibodies produced in autoimmune hepatitis.

公开(公告)号：EP0658119B1

公开(公告)日：1999-04-28

申请号：EP93919158.1

申请日：1993-08-25

申请人： CHEMOTHERAPEUTISCHES FORSCHUNGSINSTITUT GEORG-SPEYER-HAUS

发明人： DIETRICH, Ursula ,  VON BRIESEN, Hagen ,  GREZ, Manuel ,  RÜBSAMEN-WAIGMANN, Helga

IPC分类号： A61K39/21 ,  C07K7/04 ,  G01N33/569 ,  C12N15/48

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N7/00 ,  C12N2740/15022 ,  C12N2740/16021 ,  C12N2740/16122

摘要： Three new HIV-1 isolates HIV-1D747 (ECACC V92082718), HIV-1D757 (ECACC V92082719) and HIV-1D760 (ECACC V92082720) are disclosed, which represent a further indenpendent subtype of the HIV-1 family and have been recovered from Indian patients which at the time when the virus was isolated showed no typical AIDS symptoms. Also disclosed are vaccines against HIV-1 infections by this subtype and a process for producing the same, as well as the use of the HIV-1 isolates to produce protective vaccines against HIV-1 infections and for therapeutical use after HIV-1 infection, as well as for differential diagnosis.

公开(公告)号：EP0551460B1

公开(公告)日：1998-09-30

申请号：EP92913343.7

申请日：1992-06-30

申请人： BOEHRINGER MANNHEIM GMBH

发明人： SEIDEL, Christoph ,  EHRLICH-WEINREICH, Gertraud ,  BAYER, Hubert ,  WIENHUES, Ursula-Henrike ,  JUNG, Günther-Gerhard ,  IHLENFELDT, Hans, Georg

IPC分类号： C07K7/04 ,  G01N33/576 ,  A61K39/29

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2770/24222

摘要： Described are new HCV peptide antigens representing part-sequences of C-100-3 and the env/core, including the C-region. These peptide antigens are suitable for use in testing for HCV antibodies, as immunogens in the production of antibodies against HCV and as vaccines against HCV.

公开(公告)号：EP0692968A4

公开(公告)日：1998-05-20

申请号：EP94911748

申请日：1994-03-30

申请人： GEN HOSPITAL CORP ,  SHISEIDO CO LTD

发明人： HIBINO TOSHIHIKO ,  TAKAHASHI TADAHITO ,  HORII IZUMI ,  GOETINCK PAUL F

IPC分类号： C12N5/06 ,  A61K31/00 ,  A61K31/195 ,  A61K38/00 ,  A61L27/00 ,  A61P17/00 ,  A61P17/02 ,  A61P43/00 ,  C07H21/04 ,  C07K5/103 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/745 ,  C12N5/10 ,  C12N9/72 ,  C12N15/09 ,  C12P21/02 ,  C12R1/91 ,  A61K35/12 ,  A61K38/43 ,  A61K39/395 ,  C07K7/00 ,  C07K7/04 ,  C12N5/00 ,  C12N5/02

CPC分类号： C12N9/6462 ,  A61K38/00 ,  C12Y304/21073

公开(公告)号：EP0552142B1

公开(公告)日：1998-01-07

申请号：EP90911332.6

申请日：1990-07-19

申请人： CONNETICS CORPORATION

发明人： CONNETICS CORPORATION

IPC分类号： C07K7/04 ,  C07K14/47 ,  C07K14/725 ,  C07K16/28 ,  C07K1/00 ,  A61K38/03 ,  A61K38/17 ,  C12P21/04

CPC分类号： C07K16/2809 ,  A61K38/00 ,  C07K14/7051

摘要： Peptides and pharmaceutical compositions comprising immunogenic peptides of a marker T cell receptor (TCR) characteristic of an immune-related disease, capable of preventing, suppressing, or treating the disease, are disclosed. In a preferred embodiment, the amino acid sequence of the peptide corresponds to at least part of a complementary determining region (CDR) or a hypervariable region of the TCR. Antibodies and/or T cells immunologically reactive to the TCR peptide capable of preventing, suppressing, or treating an immune-related disease by passive transfer are also disclosed.

公开(公告)号：EP0412951B1

公开(公告)日：1997-09-24

申请号：EP90870110.5

申请日：1990-07-16

申请人： WASHINGTON UNIVERSITY

发明人： Hunter, Dale Donald ,  Merlie, John Paul ,  Sanes, Joshua Richard ,  Adams, Steven Paul

IPC分类号： C07K7/04 ,  C07K7/06 ,  C07K5/08 ,  C07K5/10 ,  C07K14/78 ,  A61K38/04 ,  A61K38/39

CPC分类号： C07K5/0808 ,  A61K38/00 ,  C07K5/101 ,  C07K14/78

公开(公告)号：EP0154902B1

公开(公告)日：1995-05-24

申请号：EP85102250.9

申请日：1985-02-28

申请人： New York Blood Center, Inc. ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： Neurath, Alexander Robert ,  Kent, Stephen B. H.

IPC分类号： C07K7/04 ,  A61K39/29 ,  A61K47/48 ,  C07K14/02 ,  G01N33/576 ,  C07K1/06 ,  A61K9/127

CPC分类号： C07K14/005 ,  A61K9/1271 ,  A61K39/00 ,  A61K47/58 ,  A61K47/645 ,  A61K47/6911 ,  C07K16/082 ,  C12N2730/10122 ,  G01N33/5764 ,  Y02A50/466 ,  Y10S930/221 ,  Y10S930/222 ,  Y10S930/223 ,  Y10S930/26 ,  Y10S930/27

摘要： A hepatitis B vaccine containing a peptide with an amino acid chain of at least six consecutive amino acids within the pre-S gene coded region of the envelope of hepatitis B virus. The vaccine being free of an amino acid sequence corresponding to the naturally occurring envelope proteins of hepatitis B virus and a physiologically acceptable diluent. The peptide being free or linked to a carrier. The carrier being a conventional carrier or a novel carrier including a lipid vesicle stabilized by cross-linking and having covalently bonded active sites on the outer surface thereon. Such novel carrier being useful not only to link the novel peptide containing an amino acid chain with amino acids within the pre-S gene coded region of the surface antigen of hepatitis B virus, but can also be used to bind synthetic peptide analogues of other viral proteins, as well as bacterial, allergen and parasitic proteins of man and animals. The peptides of the invention can be utilized in diagnostics for the detection of antigens and antibodies.