公开(公告)号：EP0892797A4

公开(公告)日：2004-10-20

申请号：EP97906761

申请日：1997-02-24

申请人： SQUIBB BRISTOL MYERS CO

发明人： DING CHARLES Z ,  HUNT JOHN T ,  KIM SOONG-HOON ,  MITT TOOMIS ,  BHIDE RAJEEV ,  LEFTHERIS KATERINA

IPC分类号： C07D401/14 ,  A61K31/00 ,  A61K31/35 ,  A61K31/4178 ,  A61K31/495 ,  A61K31/498 ,  A61K31/55 ,  A61K31/551 ,  A61K31/5513 ,  A61K31/675 ,  A61P35/00 ,  A61P43/00 ,  C07D20060101 ,  C07D243/14 ,  C07D245/06 ,  C07D401/04 ,  C07D401/10 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D453/02 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D491/044 ,  C07D491/048 ,  C07D495/04 ,  C07D497/04 ,  C07D513/04 ,  C07F9/645

CPC分类号： C07D243/14 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D473/00 ,  C07D487/04 ,  C07D495/04

公开(公告)号：EP1043324B1

公开(公告)日：2004-06-16

申请号：EP98953025.8

申请日：1998-11-12

申请人： Mitsubishi Chemical Corporation

发明人： TANAKA, Toshihiko Mitsubishi Chemical Corporation ,  IWASHITA, Eiichirou Mitsubishi Chemical Corporat. ,  TARAO, Akiko Mitsubishi Chemical Corporation ,  AMENOMORI, Akira Mitsubishi Chemical Corporation ,  ONO, Yuya Mitsubishi Chemical Corporation

IPC分类号： C07D473/00 ,  C07D473/06 ,  C07D473/16 ,  C07D473/18 ,  C07D473/28 ,  C07D473/32 ,  C07D473/34 ,  C07D473/40 ,  C07D239/48 ,  C07D239/50 ,  C07D473/20 ,  C07D473/30 ,  C07D473/36 ,  C07D239/42 ,  A61K31/52 ,  A61P11/06

CPC分类号： C07D473/30

摘要： Purine derivatives represented by general formula (I) or salts thereof, useful as the active ingredient of medicines such as antasthmatic, wherein R1 represents C¿1?-C4 alkyl or difluoromethyl; R?2¿ represents tetrahydrofuranyl, C¿1?-C7 alkyl, etc.; X represents hydrogen, halogeno or nitro; and A represents a group represented by general formula (II) or (III), wherein R?3¿ represents hydrogen, halogeno, etc.; and R?4 and R5¿ represent each hydrogen, halogeno, C¿1?-C4 alkyl, C1-C4 alkoxy, etc.

公开(公告)号：EP1419157A2

公开(公告)日：2004-05-19

申请号：EP02750769.8

申请日：2002-08-01

申请人： Ustav Experimentalni Botaniky Akademie ved Ceské Republiky

发明人： DOLEZAL, Karel ,  POPA, Igor ,  HOLUB, Jan ,  LENOBEL, René ,  WERBROUCK, Stefaan ,  STRNAD, Miroslav ,  ZATLOUKAL, Marek

IPC分类号： C07D473/00 ,  A61K7/00 ,  A61K31/52 ,  A01N43/90 ,  A61P35/00

CPC分类号： A01N43/90 ,  A61K8/4953 ,  A61Q19/00 ,  A61Q19/08

摘要： New heterocyclic derivatives of formula (1) based on N6-substituted adenine, having anticancer, mitotic, imunosuppressive and antisenescent propoerties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.

公开(公告)号：EP0711771B1

公开(公告)日：2003-11-12

申请号：EP95120531.9

申请日：1990-02-08

申请人： Shire BioChem Inc.

发明人： Belleau, Bernard ,  Nguyen-Ba, Nghe ,  Belleau, Pierette

IPC分类号： C07D473/00 ,  C07D411/04 ,  C07D411/14 ,  C07D327/04

CPC分类号： C07D411/14 ,  C07D327/04 ,  C07D405/04 ,  C07D411/04 ,  C07D473/00 ,  C07D473/40

公开(公告)号：EP1036794B1

公开(公告)日：2003-08-27

申请号：EP98955937.2

申请日：1998-11-26

申请人： Dainippon Pharmaceutical Co., Ltd.

发明人： MURATA, Teruya ,  MASUMOTO, Kaoru ,  KONDO, Katsunori ,  FURUKAWA, Kiyoshi ,  OKA, Makoto

IPC分类号： C07D473/00 ,  A61K31/52

CPC分类号： C07D473/00

公开(公告)号：EP1235798A4

公开(公告)日：2003-04-23

申请号：EP00975397

申请日：2000-10-26

申请人： MERCK & CO INC ,  MERCK SHARP & DOHME

发明人： THOMPSON WAYNE ,  CLAREMON DAVID A ,  MUNSON PETER M ,  WHITTER WILLIE ,  KULAGOWSKI JANUSZ ,  HUSCROFT IAN

IPC分类号： C07D487/04 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/519 ,  A61P9/10 ,  A61P25/04 ,  A61P25/06 ,  A61P25/16 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D401/06 ,  C07D471/04 ,  C07D473/00 ,  C07D201/00

CPC分类号： C07D401/06 ,  C07D471/04 ,  C07D473/00

公开(公告)号：EP0674634B1

公开(公告)日：2003-04-16

申请号：EP93900063.4

申请日：1992-12-21

申请人： BIOCHEM PHARMA INC

发明人： MANSOUR, Tarek ,  TSE, Allan H.L. ,  EVANS, Colleen, A. ,  JIN, Haolun ,  ZACHARIE, Boulos ,  NGUYEN-BA, Nghe ,  BELLEAU, Bernard +di

IPC分类号： C07D411/04 ,  C07D473/00 ,  C07D473/40 ,  C07D327/04

CPC分类号： C07D327/04 ,  C07D405/04 ,  C07D411/04 ,  C07D411/14 ,  C07D473/00 ,  C07D473/40

摘要： Disclosed are processes for preparing compounds of formula (I) and pharmaceutically acceptable salts or esters thereof, wherein R2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S = O or SO2. The invention also relates to intermediates of use in the preparation of these compounds.

公开(公告)号：EP0734387B1

公开(公告)日：2002-04-10

申请号：EP95905886.8

申请日：1994-12-12

申请人： Merck & Co., Inc.

发明人： HUFF, Joel, R. ,  VACCA, Joseph, P. ,  DORSEY, Bruce, D.

IPC分类号： C07D473/00 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  C07D498/04 ,  A61K31/52 ,  A61K31/495 ,  C07D307/79 ,  C07D307/81 ,  C07D333/54 ,  C07D333/58

CPC分类号： C07D491/04 ,  C07D241/04 ,  C07D307/81 ,  C07D405/06 ,  C07D495/04

摘要： Compounds of formula (I) are HIV protease inhibitors. These compounds are useful in the prevention or treatment of infection by HIV and in the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

公开(公告)号：EP0656778B1

公开(公告)日：2001-05-30

申请号：EP93920366.7

申请日：1993-08-25

申请人： UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. ,  EMORY UNIVERSITY

发明人： CHU, Chung, K. ,  SCHINAZI, Raymond, F.

IPC分类号： A61K31/52 ,  C07D405/04 ,  C07D473/00 ,  C07F9/6561

CPC分类号： C07D473/00 ,  A61K31/675 ,  A61K31/70 ,  A61K31/704 ,  A61K31/7076 ,  A61K38/21 ,  C07B2200/07 ,  C07D327/04 ,  C07D411/04 ,  C07D497/08 ,  A61K2300/00

摘要： A method and composition for the treatment of humans infected with HIV that includes the administration of an HIV treatment amount of an enantiomerically pure β-D-dioxolanyl purine nucleoside of formula (I), wherein R is OH, Cl, NH2, or H, or a pharmaceutically acceptable salt or derivative of the compound, optionally in a pharmaceutically acceptable carrier or diluent.

公开(公告)号：EP0702682B1

公开(公告)日：2001-03-14

申请号：EP94917117.7

申请日：1994-06-09

申请人： ROLABO SL

发明人： JACKSON, William, Paul

IPC分类号： C07D473/00

CPC分类号： C07D473/00

摘要： A process for the preparation of an amino acid ester of a nucleoside analogue, said process comprising reacting a nucleoside analogue having an esterifiable hydroxy group in its linear or cyclic ether moiety with a 2-oxa-4-aza-cycloalkane-1,3-dione, which process is economical, quick and simple to perform.