公开(公告)号：EP4384272A1

公开(公告)日：2024-06-19

申请号：EP22856754.1

申请日：2022-08-09

申请人： University of Georgia Research Foundation, Inc.

发明人： HANDA, Hitesh ,  KUMAR, Anil ,  BRISBOIS, Elizabeth J.

IPC分类号： A61P31/04 ,  A61K9/00

CPC分类号： A61P31/04 ,  A61K9/0014

公开(公告)号：EP4161253A1

公开(公告)日：2023-04-12

申请号：EP21821400.5

申请日：2021-06-09

申请人： University of Georgia Research Foundation, Inc. ,  Cold Spring Harbor Laboratory

发明人： DAWE, R., Kelly ,  JACKSON, David

IPC分类号： A01H1/04 ,  A01H1/08 ,  A01H6/46 ,  C07K14/415 ,  C12N9/22 ,  C12N15/29 ,  C12N15/82

公开(公告)号：EP4132503A1

公开(公告)日：2023-02-15

申请号：EP21785329.0

申请日：2021-04-09

申请人： University of Georgia Research Foundation, Inc.

发明人： TRIPP, Ralph A. ,  MURRAY, Jackelyn ,  HOGAN, Robert Jeff

IPC分类号： A61K31/195 ,  A61P31/14

公开(公告)号：EP3986939A1

公开(公告)日：2022-04-27

申请号：EP20830946.8

申请日：2020-06-24

申请人： University of Georgia Research Foundation, Inc.

发明人： BOONS, Geert-Jan ,  LI, Xiuru

IPC分类号： C07K16/32 ,  C12P21/00

公开(公告)号：EP3945801A1

公开(公告)日：2022-02-09

申请号：EP20784706.2

申请日：2020-04-02

申请人： University of Georgia Research Foundation, Inc.

发明人： CAI, Houjian

IPC分类号： A01K67/033 ,  C07K14/00 ,  C12N7/00 ,  C12N9/22 ,  C12N15/11 ,  C12N15/113

公开(公告)号：EP3873232A1

公开(公告)日：2021-09-08

申请号：EP19878000.9

申请日：2019-10-29

申请人： University of Georgia Research Foundation, Inc.

发明人： XIE, Jin ,  ZHANG, Weizhong

IPC分类号： A23L27/00 ,  A61K8/11 ,  A61K9/50

公开(公告)号：EP3820505A1

公开(公告)日：2021-05-19

申请号：EP19834372.5

申请日：2019-07-12

申请人： University of Georgia Research Foundation, Inc.

发明人： ALLEN, James Daniel ,  ROSS, Ted, Milburn ,  WONG, Terianne, Maiko ,  BLACKWELL, Anne, Gaelle, Bebin ,  NUNEZ, Ivette, Ariela ,  BEAU RENEER, Zachary ,  HUANG, Ying

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C07K14/11 ,  C12N15/33

公开(公告)号：EP3639837A1

公开(公告)日：2020-04-22

申请号：EP19209406.8

申请日：2009-12-10

申请人： University of Georgia Research Foundation, Inc. ,  Glycosensors and Diagnostics, LLC

发明人： WOODS, Robert J. ,  YANG, Loretta

IPC分类号： A61K38/00 ,  C07K9/00

摘要： Provided are lectenz molecules, which are mutated carbohydrate processing enzyme enzymes that are catalytically inactive and that have had their substrate affinity increased by at least 1.2 fold. Further provided are methods for making and methods of using such lectenz. Additional mutated proteins following the lectenz approach are further provided.

公开(公告)号：EP3598865A1

公开(公告)日：2020-01-29

申请号：EP18763588.3

申请日：2018-03-08

申请人： University of Georgia Research Foundation, Inc.

发明人： TRIPP, Ralph A.

IPC分类号： A61K39/13 ,  C12N7/00 ,  C12N15/113

公开(公告)号：EP3372685A3

公开(公告)日：2018-10-17

申请号：EP18164513.6

申请日：2014-02-05

申请人： University of Georgia Research Foundation, Inc. ,  The United States of America, as represented by The Secretary, Department of Health and Human Services ,  Thermo Fisher Scientific Inc.

发明人： KARPILOW, Jon Michael ,  OBERSTE, Mark Steven ,  TRIPP, Ralph A. ,  TOMPKINS, Stephen M.

IPC分类号： C12N15/113 ,  C12N5/00

CPC分类号： A61K39/13 ,  C12N7/00 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/12 ,  C12N2770/32021 ,  C12N2770/32034 ,  C12N2770/32052 ,  C12N2770/32351 ,  C12N2770/32651

摘要： Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.