公开(公告)号：EP2890708B1

公开(公告)日：2019-08-07

申请号：EP13832369.6

申请日：2013-08-28

申请人： The Governors of the University of Alberta ,  Doschak, Michael ,  Yang, Yang ,  Bhandari, Krishna, Hari

发明人： DOSCHAK, Michael ,  YANG, Yang ,  BHANDARI, Krishna, Hari

IPC分类号： A61K31/663 ,  A61K38/29 ,  A61K47/54 ,  A61K47/60 ,  C07K14/62 ,  C07K14/635 ,  C07K14/65 ,  C08F299/02

公开(公告)号：EP3373954A2

公开(公告)日：2018-09-19

申请号：EP16864981.2

申请日：2016-11-10

申请人： Proteothera, Inc.

发明人： PATWARI, Parth

IPC分类号： A61K38/30 ,  A61K39/35 ,  B01D15/36 ,  C07K1/18 ,  C07K7/06 ,  C07K14/47 ,  C07K14/635 ,  C07K14/65 ,  C12N15/09

CPC分类号： C07K1/22 ,  C07K2319/20

摘要： The invention provides methods of producing and purifying fusion proteins containing a domain capable of binding one or more extracellular matrix components, such as heparin and chondroitin sulfate, by cation-exchange chromatography.

公开(公告)号：EP2650009B8

公开(公告)日：2018-07-18

申请号：EP13001965.6

申请日：2008-08-01

申请人： The General Hospital Corporation ,  Chugai Pharmaceutical Co., Ltd.

发明人： Gardella, Thomas J. ,  Potts, John T. ,  Shimizu, Masaru ,  Ichikawa, Fumihiko ,  Jüppner, Harald ,  Okazaki, Makoto

IPC分类号： A61K38/29 ,  C07K14/635

CPC分类号： G01N33/56966 ,  A61K38/00 ,  A61K49/00 ,  C07K14/635 ,  C07K14/723 ,  G01N33/74 ,  G01N2333/645 ,  G01N2333/726

摘要： The present invention relates to a polypeptide, or pharmaceutically acceptable salt thereof, comprising the formula PTH(1-X)/PTHrP(Y-36). Further, the present invention refers to a polypeptide which binds the PTH receptor and has a high affinity for the R 0 form of the PTH receptor and to a polypeptide having affinity for PTH RG and a low affinity for PTH R 0 . Moreover, the present invention includes to a pharmaceutical composition comprising such polypeptide. The present invention further relates to a polypeptide or a pharmaceutical composition of the present invention for use in a method for treating a disease or condition. Moreover, the present invention refers to a nucleic acid comprising a sequence encoding a polypeptide of the present invention, a vector comprising said nucleic acid, a cell comprising said vector and a method of making a polypeptide of the present invention. Finally, the present invention further relates to a method for determining whether a candidate compound is a long-acting agonist of a G protein coupled receptor (GPCR).

公开(公告)号：EP2569003B1

公开(公告)日：2017-10-25

申请号：EP11781266.9

申请日：2011-05-12

申请人： The General Hospital Corporation ,  Chugai Seiyaku Kabushiki Kaisha

发明人： GARDELLA, Thomas, J. ,  POTTS, John, T. ,  JUPPNER, Harald ,  OKAZAKI, Makoto

IPC分类号： A61K38/29 ,  A61K48/00 ,  C12P21/06 ,  A61P5/00 ,  C07K14/635

CPC分类号： A61K38/29 ,  C07K14/635

公开(公告)号：EP3159408A1

公开(公告)日：2017-04-26

申请号：EP16156009.9

申请日：2008-08-18

申请人： Biochrom Pharma Inc.

发明人： Kremer, Richard ,  Huang, Dao Chao

IPC分类号： C12N15/11 ,  A61K31/713 ,  A61K48/00 ,  A61K49/16 ,  A61K51/10 ,  A61P35/00 ,  C07K16/26 ,  C12N15/12 ,  C12N15/16 ,  C12N5/16 ,  C07K14/635 ,  C12P21/08

CPC分类号： A61K31/713 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/26 ,  C07K16/30 ,  C07K16/3015 ,  C07K16/3053 ,  C07K16/3069 ,  C07K2317/73 ,  C12N15/1136 ,  C12N2310/14

摘要： The present invention is directed to the use of an effective amount of an isolated antibody that specifically binds an N-terminal portion of one or more PTHrP isoforms or a C-terminal portion of the PTHrP 1-173 isoform for inhibiting the growth and metastatis of cancer cells, more preferably wherein the antibody is a monoclonal antibody.

摘要翻译： 本发明涉及有效量的分离抗体的用途，所述分离抗体特异性结合一种或多种PTHrP同种型的N-末端部分或PTHrP1-173同种型的C-末端部分用于抑制生长和转移 癌细胞，更优选其中抗体是单克隆抗体。

公开(公告)号：EP3036252A1

公开(公告)日：2016-06-29

申请号：EP14793628.0

申请日：2014-08-21

申请人： Cadila Healthcare Limited

发明人： MENDIRATTA, Sanjeev Kumar ,  BANDYOPADHYAY, Sanjay ,  SINGH, Avanish Kumar

IPC分类号： C07K14/635

CPC分类号： C07K14/635 ,  B01D15/363 ,  C07K1/18

摘要： The present invention relates to improved method for purification of a recombinant parathyroid hormone (rhPTH
1-34 or teriparatide), said process for purification of parathyroid hormone comprising following essential steps: (a) Enzymatic cleavage; (b) anion exchange chromatography, followed by other suitable purification steps; wherein step (a) and (b) can be carried out in any order.

摘要翻译： 本发明涉及用于纯化重组甲状旁腺激素（rhPTH1-34或特立帕肽）的改进方法，所述的甲状旁腺激素纯化方法包括以下必要步骤：（a）酶切; （b）阴离子交换层析，然后进行其他合适的纯化步骤; 其中步骤（a）和（b）可以以任何顺序进行。

公开(公告)号：EP2719393A4

公开(公告)日：2015-04-08

申请号：EP12796142

申请日：2012-05-31

申请人： ASAHI KASEI PHARMA CORP

发明人： NISHIO FUMIHIDE ,  MAEJIMA TAKUJI ,  MITOME YOSHIRO

IPC分类号： A61K38/22 ,  A61K9/19 ,  A61K38/29 ,  A61P19/10 ,  C07K14/635 ,  F26B5/06 ,  G01N30/88 ,  G01N33/68

CPC分类号： C07K14/635 ,  A61K9/19 ,  A61K38/29 ,  B65B55/10 ,  B65B55/12 ,  B65B63/08 ,  G01N30/7233

摘要： [Problem] Provided is a freeze-dried preparation containing high-purity PTH peptide and a method for the production thereof. Also provided is a test method for PTH analogs to confirm the purity of a freeze-dried preparation containing PTH peptide, and the like. [Solution] In the present invention, the presence of PTH analogs produced during the manufacturing process of a freeze-dried preparation containing PTH peptide was confirmed. The production of these PTH analogs was also discovered to be markedly prevented or reduced by controlling exposure of the solution containing PTH peptide and the like to air environments within a pharmaceutical production facility.

公开(公告)号：EP1817056B1

公开(公告)日：2014-08-13

申请号：EP05851439.9

申请日：2005-11-08

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： SCADDEN, David, T. ,  ADAMS, Gregor ,  KORNENBERG, Henry ,  CALVI, Laura, M.

IPC分类号： A61K38/29 ,  C07K14/635 ,  C12N5/00 ,  C12N5/02 ,  G01N33/53

CPC分类号： A61K38/29 ,  C12N5/0647 ,  C12N2501/37 ,  C12N2502/1394

公开(公告)号：EP1948692B1

公开(公告)日：2014-01-08

申请号：EP06837570.8

申请日：2006-11-13

申请人： Amgen, Inc

发明人： KOSTENUIK, Paul ,  SHEN, Wenyan ,  BOONE, Thomas Charles

IPC分类号： C07K16/28 ,  C07K19/00 ,  C07K14/635 ,  A61K39/395 ,  A61P19/10 ,  A01K67/027 ,  C07K14/705

CPC分类号： C07K16/241 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/105 ,  A01K2267/03 ,  A61K2039/505 ,  C07K14/635 ,  C07K14/70575 ,  C07K16/2875 ,  C07K2317/21 ,  C07K2317/76 ,  C07K2319/00

公开(公告)号：EP1531836B1

公开(公告)日：2010-11-10

申请号：EP03771535.6

申请日：2003-05-23

申请人： Medtronic, Inc.

发明人： SEO, Jin Seog ,  HOLMQUIST, Barton

IPC分类号： A61K33/24 ,  A61K38/16 ,  A61K39/00 ,  A01N59/16 ,  C07K1/12 ,  C07K14/60 ,  C07K14/635

CPC分类号： C07K14/635 ,  C07K1/12 ,  C07K14/60

摘要： The invention provides a palladium-promoted hydrolytic polypeptide cleavage process which selectively cleaves the polypeptide at a Cys-His cleavage site comprising solubilizing the polypeptide in a reaction mixture comprised of a palladium promotor dissolved in a high- concentration formic acid, wherein the concentration of the formic acid in the reaction mixture is between about 1 to about 22 molar.