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公开(公告)号：EP3339445B1
公开(公告)日：2020-07-15
申请号：EP17209717.2
申请日：2007-09-07
申请人： AbbVie Bahamas Ltd.
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公开(公告)号：EP3339445A1
公开(公告)日：2018-06-27
申请号：EP17209717.2
申请日：2007-09-07
申请人： AbbVie Bahamas Ltd.
发明人： WU, Chengbin , DIXON, Richard, W. , BELK, Jonathan, P. , YING, Hua , ARGIRIADI, Maria, A. , CUFF, Carolyn, A. , HINTON, Paul, R. , KUMAR, Shankar , MELIM, Terry, L. , CHEN, Yan
摘要： The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
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公开(公告)号：EP2580221B1
公开(公告)日：2015-10-21
申请号：EP11726598.3
申请日：2011-06-08
申请人： AbbVie Bahamas Ltd.
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00
CPC分类号： C07D495/04
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公开(公告)号：EP2853531A2
公开(公告)日：2015-04-01
申请号：EP14190636.2
申请日：2010-06-10
申请人： AbbVie Bahamas Ltd.
发明人： Randolph, John T. , Matulenko, Mark A. , Keddy, Ryan G. , Jinkerson, Tammie K. , Hutchinson, Douglas K. , Flentge, Charles A. , Wagner, Rolf , Maring, Clarence J. , Tufano, Michael D. , Betebenner, David A. , Rockway, Todd W. , Degoey, David A. , Liu, Dachun , Pratt, John K. , Sarris, Kathy , Woller, Kevin R. , Wagaw, Seble H. , Califano, Jean C. , Li, Wenke , Caspi, Daniel D. , Bellizzi, Mary, E. , Gao, Yi , Kati, Warren M. , Hutchins, Charles W. , Donner, Pamela L. , Krueger, Allan C. , Motter, Christopher E , Nelson, Lissa T. , Patel, Sachin V.
IPC分类号： C07D403/14 , C07D401/14 , C07D417/14 , A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/4439 , A61P31/14
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译： 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号：EP2580219B1
公开(公告)日：2015-02-25
申请号：EP11726595.9
申请日：2011-06-08
申请人： AbbVie Bahamas Ltd.
IPC分类号： C07D495/04 , A61K31/4365 , A61P35/00
CPC分类号： A61K31/4365 , A61K31/282 , A61K31/337 , A61K31/706 , C07D495/04
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公开(公告)号：EP2411372B1
公开(公告)日：2014-07-23
申请号：EP10711968.7
申请日：2010-03-24
申请人： AbbVie Bahamas Ltd.
IPC分类号： C07D239/54 , C07D311/08
CPC分类号： C07D239/54 , C07C303/40 , C07C311/08 , C07F7/0812
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公开(公告)号：EP2468287B1
公开(公告)日：2014-04-23
申请号：EP12161047.1
申请日：2009-09-10
发明人： Ku, Yiyin , Or, Yat, Sun , Wagaw, Sable, H. , Engstrom, Ken , Grieme, Tim , Sheikh, Ahmad , Mei, Jianzhang , McDaniel, Keith, F. , Chen, Hui-ju , Shanley, Jason, P. , Kempf, Dale, J. , Grampovnik, David, J. , Sun, Ying , Liu, Dong , Gai, Yonghua , Sun, Ying
IPC分类号： A61K38/00 , A61K38/12 , C07D487/04
CPC分类号： C07K1/113 , C07D487/04
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公开(公告)号：EP2468286B1
公开(公告)日：2014-04-23
申请号：EP12160849.1
申请日：2009-09-10
发明人： Ku, Yiyin , Or, Yat, Sun , Wagaw, Sable, H. , Engstrom, Ken , Grieme, Tim , Sheikh, Ahmad , Mei, Jianzhang , McDaniel, Keith, F. , Chen, Hui-ju , Shanley, Jason, P. , Kempf, Dale, J. , Grampovnik, David, J. , Sun, Ying , Liu, Dong , Gai, Yonghua
IPC分类号： A61K38/00 , A61K38/12 , C07D487/04
CPC分类号： C07K1/113 , C07D487/04
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9.发明公开Trisubstituted heterocycles as replication inhibitors of hepatitis C virus HCV 有权Trisubstituierte Heterocyclen als Inhibitoren der Hepatitis C Virus HCV Replikation
公开(公告)号：EP2628481A1
公开(公告)日：2013-08-21
申请号：EP13167828.6
申请日：2010-06-10
申请人： AbbVie Bahamas Ltd.
发明人： Randolph, John T. , Degoey, David A. , Kati, Warren M. , Hutchins, Charles W. , Donner, Pamela L. , Krueger Allan C. , Motter, Christopher E. , Nelson, Lissa T. , Patel, Sachin V. , Matulenko, Mark A. , Keddy, Ryan G. , Jinkerson, Tammie K. , Hutchinson Douglas K. , Flentge, Charles A. , Wagner, Rolf , Maring, Clarence J. , Tufano, Michael D. , Betebenner, David A. , Rockway, Todd W. , Liu, Dachun , Pratt, John K. , Sarris, Kathy , Woller, Kevin R. , Wagaw, Seble H. , Califano, Jean C. , Li, Wenke , Caspi, Daniel.D. , Bellizzi, Mary, E. , Gao, Yi
IPC分类号： A61K31/4025 , A61K31/4178 , A61K31/4184 , A61K31/4439 , A61P31/14 , C07D401/14 , C07D417/14 , C07D403/14
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus ("HCV") are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译： 描述了有效抑制丙型肝炎病毒（“HCV”）复制的化合物。 本发明还涉及制备这种化合物的方法，包含这些化合物的组合物，以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号：EP3524685A1
公开(公告)日：2019-08-14
申请号：EP19164395.6
申请日：2007-09-07
申请人： AbbVie Bahamas Ltd.
发明人： WU, Chengbin , DIXON, Richard, W. , BELK, Jonathan, P. , YING, Hua , ARGIRIADI, Maria, A. , CUFF, Carolyn, A. , HINTON, Paul, R. , KUMAR, Shankar , MELIM, Terry, L. , CHEN, Yan
摘要： The present invention encompasses IL-13 binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hIL-13 and neutralize hIL-13 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-13 and for inhibiting hIL-13 activity, e.g., in a human subject suffering from a disorder in which hIL-13 activity is detrimental.
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