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公开(公告)号：EP3172216B1
公开(公告)日：2018-10-10
申请号：EP14772458.7
申请日：2014-08-22
IPC分类号： C07F9/24 , C07H19/073 , A61K33/42 , A61P35/00
CPC分类号： C07H19/10 , A61K33/42 , C07F9/24 , C07F9/6561 , C07H19/073
摘要： The subject matter of the invention is novel 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
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2.发明授权2',3'-DIDEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF 有权2'，3'-二脱氧-5-氟尿嘧啶衍生物，其制备方法及其应用
公开(公告)号：EP3105243B1
公开(公告)日：2018-02-21
申请号：EP14716996.5
申请日：2014-03-04
IPC分类号： C07H19/073 , A61K31/7072 , A61P31/00
CPC分类号： C07H19/06 , A61K31/513 , A61K31/7072 , C07D453/04 , C07H19/073
摘要： 2′,3′-dideoxy-5-fluorouridine derivatives have general formula 1: wherein: R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. A process for the manufacture of 2′,3′-dideoxy-5-fluorouridine derivatives of general formula 1 and application of 2′,3′-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer and hepatic cancer are also indicated.
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公开(公告)号：EP3328201A1
公开(公告)日：2018-06-06
申请号：EP16750266.5
申请日：2016-07-27
发明人： SMIGLAK, Marcin , POSPIESZNY, Henryk , KUKAWKA, Rafa , LEWANDOWSKI, Piotr , STOLARSKA, Olga , MACIEJEWSKI, Hieronim
IPC分类号： A01N43/828 , A01N43/653 , A01P21/00 , A01P3/00 , A01P15/00
CPC分类号： A01N43/82 , A01N43/653
摘要： Disclosed herein are amide 7-carboxybenzo[1,2,3]thiadiazoles and derivatives thereof having a general Formula I, as described herein. Combinations and compositions of these compounds are also disclosed. The compounds and compositions can be used as a plant stimulant. For example, the compounds compositions can be used to regulate the plant's growth, regulate the plant's metabolic processes, regulate the plant's physiological processes, prevent against effects of biotic stress in the plant, or prevent against effects of abiotic stress in the plant. In some embodiments, the composition can provide multiple disease resistance to plants infected with a fungus, virus, or bacteria.
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5.发明公开2,3'-Anhydro-2'-deoxy-5-fluorouridine derivatives with cytotoxic activity, a manufacturing process and application 审中-公开具有细胞毒活性的2,3'-脱氢-2'-脱氧-5-氟尿苷衍生物，生产方法和应用
公开(公告)号：EP3172216A1
公开(公告)日：2017-05-31
申请号：EP14772458.7
申请日：2014-08-22
IPC分类号： C07F9/24 , C07H19/073 , A61K33/42 , A61P35/00
CPC分类号： C07H19/10 , A61K33/42 , C07F9/24 , C07F9/6561 , C07H19/073
摘要： The subject matter of the invention is novel 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 where R is a trifluoromethyl, 2,2,2-trifluoroethyl, difluoromethyl, perfluoroethyl, 1-fluoroethyl, 2-fluoroethyl, 1,1-difluoroethyl, 1,2-difluoroethyl, 2,2-difluoroethyl, 1,1,2-trifluoroethyl, 1,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl, 1,2,2,2-tetrafluoroethyl group. In a second aspect, the subject matter of the invention is a process for the manufacture of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1. In a third aspect, the subject matter of the invention is an application of 2,3′-anhydro-2′-deoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer, lung cancer and nasopharynx cancer.
摘要翻译： 本发明的主题是通式1的新的2,3'-脱水-2'-脱氧-5-氟尿苷衍生物，其中R是三氟甲基，2,2,2-三氟乙基，二氟甲基，全氟乙基，1-氟乙基， 2-氟乙基，1,1-二氟乙基，1,2-二氟乙基，2,2-二氟乙基，1,1,2-三氟乙基，1,2,2-三氟乙基，1,1,2,2-四氟乙基， 2,2,2-四氟乙基。 第二方面，本发明的主题是制备通式1的2,3'-脱水-2'-脱氧-5-氟尿苷衍生物的方法。在第三方面，本发明的主题 是通式1的2,3'-脱水-2'-脱氧-5-氟尿苷衍生物在乳腺癌，宫颈癌，肺癌和鼻咽癌的抗癌治疗中的应用。
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6.发明公开2',3'-DIDEOXY-5-FLUOROURIDINE DERIVATIVES, A PROCESS FOR THE MANUFACTURE THEREOF AND APPLICATION THEREOF 有权2”，3'-二脱氧-5-氟尿苷衍生物，METHOD FOR THEREOF AND USE其制造
公开(公告)号：EP3105243A1
公开(公告)日：2016-12-21
申请号：EP14716996.5
申请日：2014-03-04
IPC分类号： C07H19/073 , A61K31/7072 , A61P31/00
CPC分类号： C07H19/06 , A61K31/513 , A61K31/7072 , C07D453/04 , C07H19/073
摘要： 2′,3′-dideoxy-5-fluorouridine derivatives have general formula 1: wherein: R1 denotes cinchona alkaloid fragment with defined absolute configuration at C-8 and C-9 atoms. A process for the manufacture of 2′,3′-dideoxy-5-fluorouridine derivatives of general formula 1 and application of 2′,3′-dideoxy-5-fluorouridine derivatives of general formula 1 in the anticancer treatment of breast cancer, cervical cancer and hepatic cancer are also indicated.
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公开(公告)号：EP2473551A1
公开(公告)日：2012-07-11
申请号：EP10757642.3
申请日：2010-08-16
IPC分类号： C08G77/385 , C08G77/04 , B01J23/46
CPC分类号： C08G77/385 , C07F7/0879 , C08G77/045 , C08G77/12 , C08G77/14 , Y02P20/582
摘要： The subject of invention is the method of synthesis of fluorosilicone co-polymers of arbitrary topology and general formula 1 in which among others if A stands for CH-O(CH
2 )
m (CF
2 )
n CF
2 H group, then the method is based on hydrosilylation reaction of appropriate fluoroalkyl-allyl ether with polyhydrosiloxanes containing at least one Si-H group, catalyzed by siloxide rhodium complex. If A stands for in which Z stands for divalent group either then the method is based on the reaction of nucleophilic opening of oxirane ring in appropriate epoxyfunctional co-polysiloxanes, in acidic environment.-
公开(公告)号：EP2473549A1
公开(公告)日：2012-07-11
申请号：EP10759741.1
申请日：2010-08-16
IPC分类号： C08G77/04
CPC分类号： C08G77/045 , C08G77/38 , C08G77/385 , C08G77/46
摘要： The subject of the invention is the method of synthesis of fluoracarbofunctional cage silsesquioxanes of the general formula in which•R1 stands for HCF2(CF2)n(CH2)mO(CH2)3Si(CH3)2O or HCF2(CF2)n(CH2)mO(CH2)3 group in which n=1-12, m=1-4;•R2, R3, R4, R5, R6, R7, R8 can be the same as R1 or different from it and stand all either for the (C1-C25) alkyl group or any aryl group, based on hydrosilylation of fluoroalkyl-allyl ether with an appropriate hydrogen-silsesquioxane in the presence of siloxide rhodium complex [{Rh(OSiMe3)(cod)}2] as a catalyst.
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公开(公告)号：EP4395900A1
公开(公告)日：2024-07-10
申请号：EP22786885.8
申请日：2022-09-02
申请人： Centre National de la Recherche Scientifique , Institut Curie , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Adam Mickiewicz University
IPC分类号： A61P35/00 , C07D493/20 , A61K31/35
CPC分类号： C07D493/20 , A61P35/00
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公开(公告)号：EP3480246A1
公开(公告)日：2019-05-08
申请号：EP17819401.5
申请日：2017-06-29
发明人： RODRÍGUEZ MARTÍNEZ, Héctor , SOTO CAMPOS, Ana María , STOLARSKA, Olga , SMIGLAK, Marcin , PAWLOWSKA, Anna
IPC分类号： C08L1/02 , C08B1/00 , C08J3/11 , C07D233/58
摘要： Mixtures of salts to dissolve cellulose. The present invention refers to a composition based in a eutectic mixture of imidazolium salts and natural biopolymers, in particular cellulose, its manufacturing process and method of use to obtain foils or films.
The composition is based in a eutectic mixture of imidazolium salts with 0.1 to 50wt% of biomass.
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