公开(公告)号：EP1313955A1

公开(公告)日：2003-05-28

申请号：EP01965858.2

申请日：2001-08-06

申请人： Biomicro Systems, Inc.

发明人： MCNEELY, Michael ,  SPUTE, Mark

IPC分类号： F15B21/00

CPC分类号： F15C1/146 ,  B01L3/502738 ,  B01L2200/146 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0694 ,  B81B1/00 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/0084 ,  Y10T137/0396 ,  Y10T137/2071 ,  Y10T137/2076 ,  Y10T137/218 ,  Y10T137/2224

摘要： A method of controlling fluid flow within a microfluidic circuit (10) using external valves and pumps connected to the circuit (10) is disclosed. The external valves and pumps, which are not a part of the microfluidic substrate (11), control fluid pumping pressure and the displacement of air (17) out of the fluid circuit (10) as fluid enters into the circuit (10). If a valve is closed, air (17) cannot be displaced out of circuit, which creates a pneumatic barrier (18) that prevents fluid from advancing within the circuit (under normal operating pressures).

公开(公告)号：EP1386169A1

公开(公告)日：2004-02-04

申请号：EP02726572.7

申请日：2002-02-07

申请人： Biomicro Systems, Inc.

发明人： MCNEELY, Michael R. ,  SPUTE, Mark K ,  ADEY, Nils

IPC分类号： G01N35/08 ,  B01L11/00

CPC分类号： F28F2260/02

摘要： A three-dimensional microfluidic device (100) formed from a plurality of substantially planar layers (101, 102, 103) sealed together is disclosed.

公开(公告)号：EP1313955A4

公开(公告)日：2004-03-24

申请号：EP01965858

申请日：2001-08-06

申请人： BIOMICRO SYSTEMS INC

发明人： MCNEELY MICHAEL ,  SPUTE MARK

IPC分类号： F15C4/00 ,  B01L3/00 ,  B81B1/00 ,  F15C1/14 ,  F15C5/00 ,  F16K99/00

CPC分类号： F15C1/146 ,  B01L3/502738 ,  B01L2200/146 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0694 ,  B81B1/00 ,  F16K99/0001 ,  F16K99/0017 ,  F16K99/0034 ,  F16K99/0057 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/0084 ,  Y10T137/0396 ,  Y10T137/2071 ,  Y10T137/2076 ,  Y10T137/218 ,  Y10T137/2224

摘要： A method of controlling fluid flow within a microfluidic circuit (10) using external valves and pumps connected to the circuit (10) is disclosed. The external valves and pumps, which are not a part of the microfluidic substrate (11), control fluid pumping pressure and the displacement of air (17) out of the fluid circuit (10) as fluid enters into the circuit (10). If a valve is closed, air (17) cannot be displaced out of circuit, which creates a pneumatic barrier (18) that prevents fluid from advancing within the circuit (under normal operating pressures).

公开(公告)号：EP1125129A1

公开(公告)日：2001-08-22

申请号：EP99951938.2

申请日：1999-10-13

申请人： Biomicro Systems, Inc.

发明人： McNEELY, Michael, R. ,  SPUTE, Mark, K. ,  OLIPHANT, Arnold, R.

IPC分类号： G01N33/567 ,  B01L3/00 ,  B01L3/02 ,  B01L11/00

CPC分类号： F15C1/14 ,  B01F5/0403 ,  B01F5/064 ,  B01F5/0642 ,  B01F13/0059 ,  B01F15/0232 ,  B01F2015/0221 ,  B01F2215/0037 ,  B01J19/0093 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/025 ,  B01L2200/0621 ,  B01L2200/0684 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0874 ,  B01L2300/0887 ,  B01L2300/165 ,  B01L2300/18 ,  B01L2400/0406 ,  B01L2400/0487 ,  B01L2400/0688 ,  B01L2400/0694 ,  F15C1/146 ,  F28F2245/04 ,  F28F2260/02 ,  G01N2035/00237 ,  G01N2035/00366 ,  G01N2035/00544 ,  Y10S366/03 ,  Y10T137/2076 ,  Y10T137/2224 ,  Y10T137/2267

摘要： Methods of controlling fluid flow through microchannels by use of passive valves or stopping means in the microchannels are presented. The passive valves act as pressure barriers impeding flow of solution past the stopping means until enough force is built up to overcome the force of the pressure barrier. Well planned use of such stopping means acting as passive valves allows the flow of fluids through microchannels to be regulated so as to allow fluids to be mixed or diluted after being introduced via a single channel, or to be split into multiple channels without the need for individual pipetting. Flow through the multiple channels can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. The filling of sister wells or chambers in this manner allows all wells or chambers to undergo reactions in unison. The use of air ducts to prevent trapping of air in the microchannels is also presented.

公开(公告)号：EP1372848A4

公开(公告)日：2006-08-09

申请号：EP02719167

申请日：2002-03-08

申请人： BIOMICRO SYSTEMS INC

发明人： MCNEELY MICHAEL ,  ADEY NILS ,  SPUTE MARK ,  AYLIFFE EDWARD ,  HOWARD MICHAEL ,  BEUTEL DARIN ,  JENSEN JOHN ,  COFFIN STEPHEN ,  MOYER THOMAS

IPC分类号： G01N33/53 ,  B01F5/10 ,  B01F11/00 ,  B01F11/02 ,  B01F13/00 ,  B01J19/00 ,  B01L3/00 ,  B01L9/00 ,  B01L99/00 ,  B81B1/00 ,  C40B60/14 ,  F16J15/10 ,  G01N33/543 ,  G01N33/566 ,  G01N35/00 ,  G01N35/02 ,  G01N37/00 ,  B01L3/02 ,  G01N1/10 ,  G01N21/00 ,  G01N31/00 ,  G01N31/22 ,  G01N33/552 ,  G01N35/08

CPC分类号： B01F5/10 ,  B01F11/0045 ,  B01F11/0266 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00351 ,  B01J2219/0043 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01L3/0293 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/5085 ,  B01L9/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/0887 ,  C40B60/14 ,  G01N33/543 ,  G01N35/00 ,  G01N35/025 ,  G01N35/028 ,  G01N2035/00158 ,  G01N2035/00237 ,  G01N2035/00544

摘要： A method and system for providing a fluidic interface to slides bearing microarrays of biomolecules or other samples immobilized thereon to perform a variety of chemical reactions or processing steps on the slide. An interface device seals against the slide to form a chamber or chambers containing all or a portion of the microarray, providing selective access to portions of the slide. The interface device includes inlet and outlet ports permitting liquid sample and reagents to be introduced to and removed from the chamber accessing the slide surface. Pre- and post- array microfluidic circuitry may be included in the interface device or in attachable modules. The system may include one or more compartments for collecting and storing waste fluids.

摘要翻译： 一种方法和系统，用于向承载微生物分子或固定在其上的其它样品的微阵列的载玻片提供流体界面，以在载玻片上进行各种化学反应或加工步骤。 接口装置密封抵靠滑块以形成容纳微阵列全部或一部分的腔室，从而提供对滑块部分的选择性接近。 界面装置包括入口和出口端口，允许液体样品和试剂被引入和移出进入滑动表面的室。 阵列后和后阵列微流体电路可以包括在接口装置或可附接模块中。 该系统可以包括用于收集和储存废液的一个或多个隔间。

公开(公告)号：EP1372848A1

公开(公告)日：2004-01-02

申请号：EP02719167.5

申请日：2002-03-08

申请人： Biomicro Systems, Inc.

发明人： MCNEELY, Michael ,  ADEY, Nils ,  SPUTE, Mark ,  AYLIFFE, Edward ,  HOWARD, Michael ,  BEUTEL, Darin ,  JENSEN, John ,  COFFIN, Stephen ,  MOYER, Thomas

IPC分类号： B01L3/02 ,  G01N21/00 ,  G01N31/22 ,  G01N31/00 ,  G01N1/10 ,  G01N35/08 ,  G01N33/566 ,  G01N33/543 ,  G01N33/552

CPC分类号： B01F5/10 ,  B01F11/0045 ,  B01F11/0266 ,  B01F13/0059 ,  B01J19/0093 ,  B01J2219/00351 ,  B01J2219/0043 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01L3/0293 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L3/5085 ,  B01L9/52 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/0877 ,  B01L2300/0883 ,  B01L2300/0887 ,  C40B60/14 ,  G01N33/543 ,  G01N35/00 ,  G01N35/025 ,  G01N35/028 ,  G01N2035/00158 ,  G01N2035/00237 ,  G01N2035/00544

摘要： A method and system for providing a fluidic interface to slides bearing microarrays of biomolecules or other samples immobilized thereon to perform a variety of chemical reactions or processing steps on the slide. An interface device seals against the slide to form a chamber or chambers containing all or a portion of the microarray, providing selective access to portions of the slide. The interface device includes inlet and outlet ports permitting liquid sample and reagents to be introduced to and removed from the chamber accessing the slide surface. Pre- and post- array microfluidic circuitry may be included in the interface device or in attachable modules. The system may include one or more compartments for collecting and storing waste fluids.

公开(公告)号：EP1222053A1

公开(公告)日：2002-07-17

申请号：EP00951031.4

申请日：2000-06-08

申请人： Biomicro Systems, Inc.

发明人： MCNEELY, Michael ,  OLIPHANT, Arnold

IPC分类号： B23K26/00

CPC分类号： B23K26/18 ,  B23K26/361 ,  B23K26/40 ,  B23K2203/42 ,  B23K2203/50

摘要： The present invention is directed to a method for laser ablation of fluorocarbon materials, such as fluorocarbon resins, and to applications for laser ablating such fluorocarbons. More specifically, a UV adsorbing additive, such as carbon black, is compounded with a fluorocarbon resin which is then subjected to laser ablation. The present invention is particularly useful for bulk structure fabrication, e.g., microstructure microfabrication.

摘要翻译： 公开了一种用于激光烧蚀掺杂碳氟化合物材料的方法，例如氟碳树脂，以及使用激光烧蚀的制品应用。 更具体地，将诸如炭黑的UV吸收添加剂与氟碳树脂复合，然后进行激光烧蚀。 本发明特别适用于本体结构制造，例如微结构微观制造。