公开(公告)号：EP2690059A1

公开(公告)日：2014-01-29

申请号：EP12177718.9

申请日：2012-07-24

申请人： Biocartis SA

发明人： Tornay, Raphaël ,  Demierre, Nicolas ,  Gamper, Stephan ,  Renaud, Philippe

IPC分类号： B81C1/00 ,  G01N15/14 ,  G01N33/543

CPC分类号： H01G13/06 ,  B01J2219/005 ,  B01J2219/00502 ,  B01J2219/00536 ,  B01J2219/00556 ,  B01J2219/00637 ,  B01L3/502707 ,  B01L3/502761 ,  B01L3/508 ,  B01L3/54 ,  B01L3/545 ,  B01L2200/0647 ,  B01L2200/10 ,  B01L2200/12 ,  B01L2300/0803 ,  B01L2300/0819 ,  B01L2300/0851 ,  B01L2300/0893 ,  B81B2201/058 ,  B81B2201/06 ,  B81C99/008 ,  G01N33/54313

摘要： The present invention relates to a method for producing microcarriers comprising the following steps:
(a) providing a wafer (6) having a sandwich structure comprising a bottom layer (7), a top layer (8) and a insulating layer (9) located between said bottom and top layers (7, 8),
(b) etching away the top layer (8) to delineate lateral walls (12) of bodies (11) of the microcarriers,
(c) depositing a first active layer (13) at least on a top surface (14) of the bodies (11),
(d) applying a continuous polymer layer (16) over the first active layer (13),
(e) etching away the bottom layer (7) and the insulating layer (9),
(f) removing the polymer layer (16) to release the microcarriers.

摘要翻译： 本发明涉及一种生产微载体的方法，包括以下步骤：（a）提供具有夹层结构的晶片（6），其包括底层（7），顶层（8）和绝缘层（9） 在所述底层和顶层之间，（b）蚀刻掉顶层（8）以描绘微载体的主体（11）的侧壁（12），（c）沉积第一有源层（13） 至少在主体（11）的顶表面（14）上，（d）在第一有源层（13）上施加连续的聚合物层（16），（e）蚀刻掉底层（7）和绝缘层 层（9），（f）去除聚合物层（16）以释放微载体。

公开(公告)号：EP2510123A1

公开(公告)日：2012-10-17

申请号：EP10807664.7

申请日：2010-12-07

申请人： Biocartis SA

发明人： VAN MEERBERGEN, Bart, Edward, Gusta, Jozef ,  PICIU, Oana, Mihaela ,  GILL, Ron ,  SCHMIDT, Kristiane, Anne ,  NEERKEN, Sieglinde ,  PONJEE, Marc, Wilhelmus, Gijsbert ,  UNAY, Zeynep, Seflek ,  PENTERMAN, Roel ,  VAN DE WIEL, Paul Arnold

IPC分类号： C12Q1/68 ,  C12N1/06

CPC分类号： C12Q1/6806 ,  C12N1/06 ,  C12Q1/689 ,  C12Q1/6895 ,  C12Q2527/125 ,  C12Q2527/119

摘要： The present invention discloses methods and devices for the selective lysis of cells in a sample comprising micro-organisms such as bacteria. The selective lysis is obtained by incubating the sample in a non-ionic detergent under alkaline conditions.

公开(公告)号：EP2488919A1

公开(公告)日：2012-08-22

申请号：EP10768363.3

申请日：2010-10-14

申请人： Biocartis SA

发明人： DEMIERRE, Nicolas ,  GAMPER, Stephan

IPC分类号： G03F7/00 ,  B01J19/00

CPC分类号： B44C1/227 ,  B01J2219/00497 ,  B01J2219/00502 ,  B01J2219/00536 ,  B01J2219/00554 ,  B01J2219/00556 ,  B01J2219/00576 ,  B01J2219/00612 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00722 ,  B81C99/008 ,  G03F7/00 ,  H01L21/0272

摘要： The present invention discloses silicon microcarriers suitable for fluorescent assays as a well as a method of producing such microcarriers. The method comprises the steps of providing a SOI wafer comprising a bottom layer of monocristalline silicone, an insulator layer and a bottom layer of monocristalline silicon, delineating microparticles, etching away the insulator layer and depositing an oxide layer on the wafer still holding the microparticles.

公开(公告)号：EP2484447A1

公开(公告)日：2012-08-08

申请号：EP11000970.1

申请日：2011-02-07

申请人： Biocartis SA

发明人： Demierre, Nicolas

IPC分类号： B01L3/00

CPC分类号： G01N21/6486 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00558 ,  B01J2219/0056 ,  B01J2219/00576 ,  B01J2219/00725 ,  B01J2219/0074 ,  B01L3/502761 ,  B01L2200/0647 ,  B01L2300/021 ,  B01L2300/0832 ,  G01N33/54313

摘要： The present invention relates to an encoded microcarrier (2) comprising a readable code attached to it for identification, said encoded microcarrier (2) comprising a body (3) having at least a detection surface (6) to detect a chemical and/or biological reaction, the microcarrier further comprising at least a spacing element (9) projecting from the body (3) and shaped to ensure that, when the encoded microcarrier (2) is laid on a flat plane with the detection surface (6) facing said flat plane, a gap exists between said flat plane and the detection surface (6). The invention also relates to an assay device designed to use a plurality of said encoded microcarriers (2) to perform assays. The invention relates finally to a method for monitoring a chemical or biological reaction.

摘要翻译： 本发明涉及一种编码的微载体（2），包括附于其上的可读代码进行识别，所述编码微载体（2）包括具有至少检测表面（6）的主体（3），以检测化学和/或生物 所述微载体还包括至少一个从所述主体（3）突出的间隔元件（9）并成形为确保当所述编码的微载体（2）放置在平面上时，所述检测表面（6）面向所述平面 在所述平面与检测面（6）之间存在间隙。 本发明还涉及被设计为使用多个所述编码的微载体（2）进行测定的测定装置。 本发明最终涉及用于监测化学或生物反应的方法。

公开(公告)号：EP2419705A1

公开(公告)日：2012-02-22

申请号：EP10713294.6

申请日：2010-04-09

申请人： Biocartis SA

发明人： VAN DOORN, Arie, R. ,  DE GIER, Ronald ,  STROUCKEN, Louis ,  VAN DE WAL, Marloes, M., E., B. ,  SHULEPOV, Sergei ,  ROOZEN, Nicolaas, B. ,  BRANTJES, Contantijn, W., M. ,  DE JONG, Michiel ,  VAN DAMME, Hendrik, S.

IPC分类号： G01N1/44

CPC分类号： G01N1/44

摘要： A device for receiving a sample carrier is provided. The device includes an opening for receiving part of the sample carrier and a cutter for removing a part of the sample carrier. The cutter is coupled to a lid, which is movable to allow the cutter to make an incision in the sample carrier and, at the same time, to close at least part of the opening left open after receipt of the sample carrier. The disclosure further relates to a system comprising such a device and a method for operating such a device.

公开(公告)号：EP1896180B1

公开(公告)日：2011-11-23

申请号：EP06765771.8

申请日：2006-06-16

申请人： Biocartis SA

发明人： VAN HAAG, Chris ,  JONGERIUS, Michiel, J. ,  SCHAEFER, Danny, G., A. ,  VAN DEN BIJGAART, Adrianus, W., D., M. ,  DE GIER, Ronald, C. ,  DE JONG, Michiel ,  PROSS, Gerhard ,  BACHER, Johannes ,  BOOS, Andreas ,  LUEDKE, Gerd ,  SEHER, Jens-Peter

IPC分类号： B01L3/00 ,  G01N1/28 ,  G01N21/76 ,  G01N35/00 ,  G01N33/487

CPC分类号： B01L7/52 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/545 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2200/10 ,  B01L2300/02 ,  B01L2300/087 ,  B01L2300/1805 ,  G01N21/6428 ,  G01N35/00069 ,  G01N2035/00158

摘要： Disclosed is a cartridge for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. The cartridge comprises a generic part and one or more separate application-specific parts, which are connectable to the generic part. Also disclosed is a system for the detection of the presence, absence and/or amount of a target nucleotide sequence in a sample comprising one or more nucleic acid sequences. This system comprising a reusable apparatus, wherein said apparatus is configured to receive a cartridge and to control a process for the detection of the presence, absence and/or amount of a target nucleotide sequence in the sample, being present in said cartridge.

公开(公告)号：EP2312393A1

公开(公告)日：2011-04-20

申请号：EP09012970.1

申请日：2009-10-14

申请人： Biocartis SA

发明人： Demierre, Nicolas ,  Gamper, Stephan

IPC分类号： G03F7/00 ,  B01J19/00

CPC分类号： B44C1/227 ,  B01J2219/00497 ,  B01J2219/00502 ,  B01J2219/00536 ,  B01J2219/00554 ,  B01J2219/00556 ,  B01J2219/00576 ,  B01J2219/00612 ,  B01J2219/00635 ,  B01J2219/00637 ,  B01J2219/00722 ,  B81C99/008 ,  G03F7/00 ,  H01L21/0272

摘要： The present invention discloses silicon microcarriers suitable for fluorescent assays as a well as a method of producing such microcarriers. The method comprises the steps of providing a SOI wafer comprising a bottom layer of monocristalline silicone, an insulator layer and a bottom layer of monocristalline silicon, delineating microparticles, etching away the insulator layer and depositing an oxide layer on the wafer still holding the microparticles.

摘要翻译： 本发明公开了适用于荧光测定的硅微载体以及生产这种微载体的方法。 该方法包括以下步骤：提供包括单晶硅的底层，绝缘层和单晶硅的底层的SOI晶片，描绘微粒，蚀刻掉绝缘体层并在保持微粒的晶片上沉积氧化物层。

公开(公告)号：EP2208075A2

公开(公告)日：2010-07-21

申请号：EP08845837.7

申请日：2008-10-22

申请人： Biocartis SA

发明人： PIERIK, Anke ,  DIJKSMAN, Johan, F.

IPC分类号： G01N35/00 ,  C12Q1/68 ,  B01L11/00

CPC分类号： C12Q1/6888 ,  B01L7/52

摘要： The invention relates to the detection of infectious diseases. A system for automatic detection of infectious diseases is disclosed. The system comprises an input unit for receiving a blood sample, a lysis unit, a PCR unit, a sample unit and a detection unit. The systemmay based on an inputted blood sample generate an output signal that isindicative of the presence of pathogen DNA in the blood sample.

公开(公告)号：EP2796859A1

公开(公告)日：2014-10-29

申请号：EP13165451.9

申请日：2013-04-25

申请人： Biocartis SA

发明人： She, King Shing Joseph

IPC分类号： G01N21/64 ,  G01N33/58

CPC分类号： G01N33/54306 ,  G01N21/6428 ,  G01N33/54353 ,  G01N33/582 ,  G01N2021/6439

摘要： The present invention relates to a method for quantifying at a functional group (1) functionalizing a surface (2). First, the method comprising the step of providing at a surface (2) having micrometric dimensions functionalized with at a functional group (1). The method includes a step of contacting the surface (2) with a solution: Said solution comprises at a first reagent (4) at a first concentration and a second reagent (5) at a second concentration, the ratio between the first concentration and the second concentration being predetermined. Said first reagent (4) and second reagent (5) are designed for selectively coupling to a functional group (2) with respective affinities, the ratio of said affinities being predetermined. The first reagent (4) is labelled for emitting fluorescence and the second reagent (5) is un-labelled. Then, the fluorescence of said first reagent (4) on the surface to quantify said functional group (1) therefrom.

摘要翻译： 本发明涉及在功能化表面（2）的官能团（1）上进行定量的方法。 首先，该方法包括在具有在官能团（1）上官能化的微米尺度的表面（2）上提供的步骤。 该方法包括使表面（2）与溶液接触的步骤：所述溶液在第一浓度的第一试剂（4）和第二浓度下包含第二试剂（5），第一浓度与 第二浓度是预定的。 所述第一试剂（4）和第二试剂（5）被设计成以各自的亲和力选择性地偶合到官能团（2），所述亲和力的比率是预定的。 标记第一试剂（4）以发射荧光，第二试剂（5）未标记。 然后，将表面上的所述第一试剂（4）的荧光从其中量化所述官能团（1）。

公开(公告)号：EP2789388A1

公开(公告)日：2014-10-15

申请号：EP13163554.2

申请日：2013-04-12

申请人： Biocartis SA

发明人： Kroon, Gerard ,  de Gier, Ronald

IPC分类号： B01L3/00 ,  G01N35/00 ,  G01N35/10

CPC分类号： F16K27/04 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/04 ,  B01L2300/049 ,  B01L2300/0809 ,  B01L2300/0832 ,  B01L2300/087 ,  B01L2400/0478 ,  B01L2400/0644 ,  F16K3/0218 ,  F16K3/30 ,  G01N35/0099 ,  G01N35/1009

摘要： The present invention relates to a fluid control and processing system (1) comprising a cartridge (2) and an instrument for operating the cartridge (2). The cartridge (2) comprises a cylinder body comprising a cylinder and a fluid port. It further comprises dispensing ports to drive at least a fluid flow, each dispensing port being positioned to be connectable, when the instrument is operating the cartridge (2), with at least a fluid port by rotation of the cylinder body. The instrument comprises a piston driver (8) for driving the piston (11). The fluid control and processing system further comprises:
- reversible fastening means for fastening the piston (11) to the piston driver (8), so that the movement of the piston (11) is controlled by the piston driver (8);
- rotating means for rotating the cylinder body.

摘要翻译： 液体控制和处理系统本发明涉及一种流体控制和处理系统（1），其包括一个盒（2）和一个用于操作盒（2）的仪器。 墨盒（2）包括一个包括圆筒和流体口的圆柱体。 它还包括分配端口以驱动至少一个流体流动，当仪器通过气缸本体的旋转而至少具有一个流体端口时，每个分配端口定位成可连接的。 仪器包括用于驱动活塞（11）的活塞驱动器（8）。 流体控制和处理系统还包括： - 用于将活塞（11）紧固到活塞驱动器（8）的可逆紧固装置，使得活塞（11）的运动由活塞驱动器（8）控制; - 用于旋转缸体的旋转装置。