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公开(公告)号：EP2057158B1
公开(公告)日：2015-08-12
申请号：EP07803060.8
申请日：2007-08-30
申请人： Cellzome Limited
发明人： WILSON, Francis , RAMSDEN, Nigel , BELL, Kathryn , CANSFIELD, Andrew , BURCKHARDT, Svenja , TAYLOR, Jess , SUNOSE, Mihiro , MIDDLEMISS, David
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P37/00 , A61P35/00
CPC分类号： C07D471/04
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公开(公告)号：EP2057158B8
公开(公告)日：2015-09-30
申请号：EP07803060.8
申请日：2007-08-30
申请人： Cellzome Limited
发明人： WILSON, Francis , RAMSDEN, Nigel , BELL, Kathryn , CANSFIELD, Andrew , BURCKHARDT, Svenja , TAYLOR, Jess , SUNOSE, Mihiro , MIDDLEMISS, David
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P37/00 , A61P35/00
CPC分类号： C07D471/04
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公开(公告)号：EP1805129B1
公开(公告)日：2009-03-18
申请号：EP05799330.5
申请日：2005-10-21
申请人： Cellzome Limited
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard, John , SUNOSE, Mihiro , HERNANDEZ-Perni, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja
IPC分类号： C07C59/68 , C07C59/72 , C07D295/22 , C07D261/08 , C07D309/06 , C07D295/18 , C07C235/34 , C07C311/17 , C07C317/22 , A61P25/28 , A61K31/192
CPC分类号： C07C59/68 , C07C59/72 , C07C233/54 , C07C235/42 , C07C311/29 , C07C317/22 , C07C317/46 , C07C2601/02 , C07C2601/14 , C07D261/08 , C07D295/192 , C07D295/26 , C07D309/06
摘要： The present invention relates to compounds having the general formula (I) with the definitions of A, X, R1-R6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of Ϝ-secretase activity.
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公开(公告)号：EP1991550A1
公开(公告)日：2008-11-19
申请号：EP07704436.0
申请日：2007-02-07
申请人： Cellzome Limited
发明人： REID, Alison , WILSON, Francis , DYKE, Hazel , PRICE, Steven , CRAMP, Sue
IPC分类号： C07D491/04 , A61K31/519 , A61P29/00
CPC分类号： C07D491/04
摘要： The present invention relates to novel amino pyrimidine compounds of formula (I) for the modulation of the histamine H4 receptor and the treatment or prevention of conditions mediated by the histamine H4 receptor. The invention also relates to the preparation of such compounds.
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公开(公告)号：EP2021314B1
公开(公告)日：2013-01-23
申请号：EP07760976.6
申请日：2007-04-20
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard John , SUNOSE, Mihiro , HERNADEZ-PERNI, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja , HO, Chih Yung , ZHANG, Yan
IPC分类号： C07C59/68 , C07C229/42 , A61K31/192 , A61K31/196 , A61P25/28
CPC分类号： C07C229/42 , C07C59/68
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公开(公告)号：EP2057158A1
公开(公告)日：2009-05-13
申请号：EP07803060.8
申请日：2007-08-30
申请人： Cellzome Limited
发明人： WILSON, Francis , RAMSDEN, Nigel , BELL, Kathryn , CANSFIELD, Andrew , BURCKHARDT, Svenja , TAYLOR, Jess , SUNOSE, Mihiro , MIDDLEMISS, David
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00 , A61P37/00 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I); wherein X and R1 to R5 have the meaning as cited in the description and the claims. Said compounds are useful as protein kinase inhibitors, especially inhibitors of Itk or PI3K, for the treatment or prophylaxis of immunological, inflammatory or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.
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公开(公告)号：EP2021314A1
公开(公告)日：2009-02-11
申请号：EP07760976.6
申请日：2007-04-20
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard John , SUNOSE, Mihiro , HERNADEZ-PERNI, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja , HO, Chih Yung , ZHANG, Yan
IPC分类号： C07C59/68 , C07C229/42 , A61K31/192 , A61K31/196 , A61P25/28
CPC分类号： C07C229/42 , C07C59/68
摘要： The present invention relates to compounds having the general Formula (I) with the definitions of X, Y, R1, R2, R3, R4 R9, and R10, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity, wherein A is O, NH, S; X is a bond or a group -CR5R6 Υ is a carboxy group -C(O)OH or a substituted or unsubstituted tetrazole group..
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公开(公告)号：EP2016039B1
公开(公告)日：2012-08-01
申请号：EP07760900.6
申请日：2007-04-19
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard, John , SUNOSE, Mihiro , HERNADEZ-PERNI, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja , ZHANG, Yan , HO, Chih Yung
IPC分类号： C07C51/09 , C07C57/38 , C07C57/58 , C07C59/64 , C07D257/04 , A61K31/192 , A61P25/28
CPC分类号： C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要： The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
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公开(公告)号：EP2016039A1
公开(公告)日：2009-01-21
申请号：EP07760900.6
申请日：2007-04-19
发明人： WILSON, Francis , REID, Alison , READER, Valerie , HARRISON, Richard, John , SUNOSE, Mihiro , HERNADEZ-PERNI, Remedios , MAJOR, Jeremy , BOUSSARD, Cyrille , SMELT, Kathryn , TAYLOR, Jess , LEFORMAL, Adeline , CANSFIELD, Andrew , BURCKHARDT, Svenja , ZHANG, Yan , HO, Chih Yung
IPC分类号： C07C51/09 , C07C57/38 , C07C57/58 , C07C59/64 , C07D257/04 , A61K31/192 , A61P25/28
CPC分类号： C07D257/04 , C07C51/09 , C07C57/38 , C07C57/58 , C07C59/56 , C07C59/64 , C07C63/331 , C07C69/65
摘要： The present invention relates to compounds having the general formula (I) with the definitions of X, Y, R1, R2, R3, R4, R9, R10 given below, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of γ-secretase activity.
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